New drug combo aims to stop lung Cancer's return
NCT ID NCT06606847
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests two drugs, durvalumab and oleclumab, given together after standard chemoradiation in 30 people with stage III lung cancer that cannot be removed by surgery. The goal is to see if the combination can delay cancer progression. Participants must have stable disease after chemoradiation and meet specific health criteria.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- durvalumab and oleclumab (two drugs given by IV infusion)
- What this could lead to
- If it works, this combination could help keep stage III lung cancer from growing back after initial chemoradiation.
- What could go wrong
- This is a small, early-phase trial with only 30 people and no comparison group. The drugs may cause side effects and may not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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30 people
The number who actually took part.
- Started
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Sep 2024
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
INCLUSION CRITERIA: * Participant must be ≥ 18 years at the time of screening. * Histologically-documented NSCLC and have been treated with concurrent or sequential CRT for locally advanced, unresectable (Stage III) disease. * Documented tumour PD-L1 status by qualified lab (local or central). * Documented EGFR and ALK wild-type status (local or central). * Patients must not have progressed following definitive, platinum based, concurrent or sequential chemoradiotherapy. * Participants must have received at least 2 cycles of platinum-based chemotherapy before or concurrent with radiation therapy. * Participants must have received a total dose of radiation of 60 Gy ±10% (54 Gy to 66 Gy) as part of the chemoradiation therapy, to be enrolled. Radiation therapy should be administered by intensity modulated RT/volumetric modulated arc therapy (preferred) or 3D-conforming technique. * WHO performance status of 0 or 1. * Adequate organ and marrow function. EXCLUSION CRITERIA: * History of another primary malignancy except for malignancy treated with curative intent with no known active disease ≥5 years before the first dose of study intervention and of low potential risk for recurrence, adequately resected non-melanoma skin cancer and curatively treated in situ disease, or adequately treated carcinoma in situ or Ta tumours without evidence of disease. * Mixed small cell and non-small cell lung cancer histology. * Participants with locally advanced (Stage III) unresectable NSCLC who have progressed during platinum-based CRT. * Any unresolved toxicity CTCAE \>Grade 2 from the prior chemoradiation therapy (excluding alopecia). * Participants with ≥grade 2 pneumonitis from prior chemoradiation therapy. * History of idiopathic pulmonary fibrosis, drug-induced pneumonitis, or idiopathic pneumonitis - regardless of time of onset prior to study treatment assignment. Evidence of active non-CRT induced pneumonitis (≥ Grade 2), active pneumonia, active ILD, active or recently treated pleural effusion, or current pulmonary fibrosis. * Active or prior documented autoimmune or inflammatory disorders (with exceptions). * Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
Kazan', 420029, Russia
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Research Site
Moscow, 111123, Russia
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Research Site
Moscow, 115478, Russia
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Research Site
Moscow, 143423, Russia
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Research Site
Nizhny Novgorod, 603126, Russia
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Research Site
Novosibirsk, 630108, Russia
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Research Site
Obninsk, 249031, Russia
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Research Site
Saint Petersburg, 197022, Russia
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Research Site
Saint Petersburg, 197758, Russia
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Research Site
Ufa, 450054, Russia
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Research Site
Yekaterinburg, 620905, Russia
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