Intermediate coronary syndrome

Researchers are testing a stent-like device called the DynamX Drug-Eluting Coronary Bioadaptor System in people with complex coronary artery blockages, including long lesions, chronic total occlusions, and blockages at artery branches. The study enrolls about 55 adults and measur…

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take on…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This study looked at whether high-intensity breathing exercises (inspiratory muscle training) can improve blood vessel function and artery stiffness in people with heart disease before they start cardiac rehab. Eleven adults who had heart surgery or related conditions took part. …

This study tested three doses of argatroban, a blood thinner, in 140 patients undergoing elective heart stent procedures. It compared argatroban to the standard blood thinner heparin, both given with clopidogrel and aspirin. The goal was to see how well argatroban prevents blood …

This study tested a special stent made of magnesium that slowly dissolves in the body. The stent releases a drug to prevent scarring and was used in 20 patients with complex blockages where arteries branch. The goal was to see if it is safe and works well for these tricky cases.

This study tested whether rosuvastatin, a common cholesterol-lowering drug, could reduce early signs of artery hardening in 121 people with ANCA-associated vasculitis. Participants were in remission and received either rosuvastatin or a placebo for up to 2 years. The goal was to …

This study tested whether adding a special pressure wire measurement (FFR) to standard angiography helps doctors decide the best treatment for people with multiple blocked heart arteries. Over 900 patients were randomly assigned to get either angiography alone or angiography plus…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study tests whether a software tool called AutocathFFR can accurately measure the severity of coronary artery blockages from standard 2D angiogram images, compared to the gold-standard invasive FFR measurement. The software uses machine learning to analyze images taken durin…

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This completed study tested whether a special ultrasound scan (IVUS) of plaque buildup in heart arteries can accurately diagnose reduced blood flow (functional myocardial ischemia). Researchers enrolled 105 adults with coronary artery disease and compared IVUS results to the stan…

This study tested a new software program that analyzes heart angiogram images to measure blood flow blockages without needing to insert a pressure wire into the artery. Researchers reviewed the records of 100 patients who had both an angiogram and an invasive pressure measurement…

This trial tests whether applying cold packs to the wrist after transradial coronary angiography reduces pain, bruising, and discomfort. About 104 adults who had this heart procedure will be randomly assigned to receive either cold packs or standard care. Researchers will measure…

This trial tests whether a single educational session about how pain works, given before coronary artery bypass surgery, can lessen chronic pain after the operation. Adults scheduled for elective bypass will either receive this pain neuroscience education plus routine care, or ro…

This trial tests whether a 20-minute foot massage, given daily for three days after open heart surgery, can reduce pain, improve sleep quality, and boost mood. Adults undergoing coronary artery bypass grafting who report significant pain after surgery are randomly assigned to rec…

This study tests whether giving a nerve block (stellate ganglion block) before coronary artery bypass grafting (CABG) can reduce the chance of developing atrial fibrillation, a common irregular heartbeat after surgery. About 60 adults having CABG will be randomly assigned to rece…

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assig…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This completed study looked at how much radiation people receive during heart CT scans (CCTA) in everyday hospital practice. Researchers enrolled 66 adults who needed a heart CT and recorded the radiation dose used, along with any dose-saving techniques. The goal was to understan…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study aims to develop a computer model that can predict how well blood flows to the heart muscle during stress, using only a standard CT scan. Currently, this requires an additional scan and a drug to simulate stress. The researchers will analyze CT scans from 400 people wit…

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study tests whether a tool called the HEART score can accurately predict the risk of serious heart problems in people who come to the emergency room with chest pain. The HEART score uses medical history, EKG results, age, risk factors, and a blood test to classify patients a…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study looked at how a nerve condition called cardiovascular autonomic neuropathy (CAN) affects the risk of kidney injury in people having heart bypass surgery. Researchers tracked 912 adults before, during, and after surgery to see if those with CAN had worse kidney function…

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This study tested a new combination of very low-dose aspirin (20 mg twice daily) plus a blood thinner called rivaroxaban (2.5 mg twice daily) in 48 adults with chronic coronary syndromes. Researchers compared this new regimen to standard aspirin alone (75 mg once daily) and stand…

This completed study looked at 160 people with coronary artery disease who needed a stent in one artery and also had a partial blockage in another. Researchers measured pressure in the second blockage before and after stenting the first, to see if treatment changed the reading. T…

This completed Phase 4 study looked at whether the blood thinner argatroban causes heart rhythm changes (QTc prolongation) in 50 patients with stable coronary artery disease or unstable angina during angioplasty. Patients received argatroban by IV and had ECGs before and after th…

This study combined data from over 1,700 patients who had a heart attack or unstable angina and underwent a special imaging test (OCT) of their heart arteries. Researchers aimed to find factors that predict plaque erosion, a common cause of heart attacks. The goal is to better un…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at 10,000 people who came to the emergency room with chest pain. Researchers tested new blood markers to see if they could diagnose heart attacks faster than current methods. The goal is to help doctors quickly rule out or confirm a heart attack, especially in t…

This study compared radiation exposure to doctors during heart procedures (coronary angiography and stenting) using two different arm artery approaches: the left distal radial artery and the conventional right radial artery. Over 1,000 patients participated. The goal was to see i…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without chest pain) increases the risk of heart problems or death in people with coronary heart disease. Researchers followed participants for one to three years. The goal was to better under…

This study used cardiac CT scans to compare the amount of high-risk plaque in the coronary arteries of 480 people with and without a family history of coronary artery disease. All participants had no prior heart problems. The goal was to see if those with a family history have mo…

This study monitored brain oxygen levels and electrical activity in 15 children aged 6 to 36 months during open heart surgery. Sensors placed on the forehead measured oxygen and brain waves every 5 minutes. The goal was to understand how these measurements relate to each other, w…