Infertility disorder

This trial tests whether a uterus transplanted from a living or deceased donor can allow women with uterine factor infertility to carry a pregnancy and give birth. The study plans to enroll 10 women who will receive a transplant, undergo embryo transfer, and attempt delivery, fol…

This pilot trial tests CAPA-IVM, a two-step laboratory process that matures eggs after they are retrieved, as an option for people with good ovarian reserve who need fertility treatment. Researchers will check how many eggs reach maturity, how many fertilize, and whether the meth…

This trial is testing whether a more affordable hormone protocol can work as well as standard IVF stimulation. Typically, IVF uses expensive gonadotropins to stimulate the ovaries to produce multiple eggs. The study compares a protocol that replaces a large portion of these with …

This study tests whether a low-caffeine green tea extract (EGCG) can shrink uterine fibroids and improve pregnancy and live birth rates in women aged 18-40 who have been trying to conceive for at least six months. Participants take the extract and are monitored for changes in fib…

This trial tests whether a technique called PICSI, which selects sperm by their ability to bind to hyaluronic acid, can improve pregnancy rates and reduce miscarriage compared to standard ICSI. It involves couples who had poor fertilization in their first IVF cycle and are now tr…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…

This Phase 3 trial tests whether taking Elagolix, a hormone-blocking drug, before IVF can increase live birth rates in women with endometriosis. About 97 women will receive either Elagolix or a placebo before their IVF cycle. The goal is to see if this pre-treatment improves the …

This study compares two common fertility treatments—letrozole alone versus clomiphene citrate plus tamoxifen—in 240 women with infertility due to ovulation problems. The goal is to see which approach leads to more ovulations and pregnancies. Participants will be monitored with ul…

This study offers girls and young teens facing strong cancer treatments the chance to freeze a piece of their ovary before therapy begins. The goal is to help preserve their ability to have biological children later in life. Around 100 participants will undergo a safe procedure t…

This study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone)—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one of the drugs for three months. The goal is to find new options for male inf…

This study tests whether shining a special red light on embryos during IVF can help them grow better. As women age, the energy centers in their cells (mitochondria) weaken, making it harder for embryos to develop. The light therapy aims to boost that energy. Researchers will comp…

This study tests whether platelet-rich plasma (PRP), made from a woman's own blood, can improve pregnancy rates in those who have had multiple failed embryo transfers. 180 women will receive PRP either as an injection into the uterus lining or as a simple infusion, and their outc…

This study tests whether text messages and counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,310 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This study compares a new microfluidic device, SwimCount Harvester, to standard sperm preparation methods in couples undergoing IVF with genetic testing (PGT-A). About 1,600 couples will be randomly assigned to one of the two methods. The goal is to see if the device leads to mor…

This study explores transplanting a uterus into women who cannot get pregnant because they were born without a womb or had it removed. Ten women under 40 with a healthy donor will receive the transplant. The goal is to see if the procedure is feasible and can restore fertility, t…

This study tests a new coating on a hip replacement implant that may help prevent infections and help the implant bond better with the bone. About 340 adults needing a hip replacement will receive either the coated or standard implant. The goal is to see if the coated implant wor…

This study looks at whether giving a higher dose of the progesterone supplement Endometrin to women with low blood levels on the day of embryo transfer can improve pregnancy rates and lower miscarriage risk. About 150 women aged 18-42 undergoing frozen embryo transfer will be spl…

This study asks women undergoing a HyFoSy (hysterosalpingo-foam sonography) exam as part of an infertility workup to rate their satisfaction and the procedure's tolerability. Participants fill out a questionnaire right after the exam, scoring their overall experience on a 0–10 sc…

This pilot study tests whether an online stress management program called Stress Free Now can lower stress and possibly increase pregnancy rates in women aged 18-34 who have been trying to conceive for 6-12 months. Forty women will be randomly assigned to either the program or a …

This study tests whether music therapy can reduce anxiety and improve pregnancy rates in women receiving artificial insemination. Researchers will compare pregnancy outcomes in 254 women who receive standard care plus music therapy versus standard care alone. The goal is to see i…

This study tests a new device called the Catheter Caps Case (C3) for dialysis patients. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adults with a dialysis catheter will try the device for 15 minutes, and researchers will measu…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study looks at whether a low-fat diet can increase reproductive hormones in women with obesity. Thirty women with regular cycles and no other hormone issues will follow a carefully controlled diet. The goal is to see if diet alone can improve hormone levels linked to fertili…

This study tests a new device called CorVision, a tiny lens made from collagen that is placed inside the cornea to improve near vision in people with presbyopia (age-related difficulty seeing up close). 110 adults aged 40-65 will receive the implant in one eye through a minimally…

Researchers at the University of California, San Francisco, are studying whether the pace at which a woman's ovaries age can signal her future risk of heart disease. The trial follows 865 women who were already part of a long-running reproductive health study. Participants underg…

This study tests whether group virtual preconception care can improve pregnancy and health outcomes for people with infertility. About 140 patients from Penn Fertility Care will either join biweekly group sessions or receive usual care. Researchers will track blood pressure, weig…

This study asks whether body fat percentage, measured by a quick bioelectrical impedance analysis (BIA) scale, is a better predictor of IVF outcomes than the traditional body mass index (BMI). Researchers will follow about 200 people undergoing IVF, measuring body composition bef…

This study aims to build a large collection of biological samples and health information from females aged 7 and older who have not yet reached natural menopause. The goal is to create a resource that researchers can use to investigate a range of women's health issues, including …

This study looks at different ways to track ovulation and the luteal phase using the Premom app. Thirty women will record cervical mucus, urine test results, and body temperature over three cycles. The goal is to see which combination of signs gives the most accurate picture of w…

This study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…

This study looks at how to best freeze and store ovarian tissue for transgender individuals who are undergoing gender-affirming therapy. The goal is to preserve the possibility of having biological children later. Researchers will test different freezing methods and examine how h…

This study looks at how to freeze and store testicular tissue from transgender individuals who are about to start gender-affirming hormone therapy. The goal is to learn the best ways to preserve sperm-producing cells so that these individuals might have the option to have biologi…

This study planned to check whether vitamin D levels affect pregnancy rates in women undergoing IVF. It was withdrawn before enrolling any participants, so no data or conclusions are available. The idea was to measure vitamin D in blood samples and compare it to IVF outcomes like…

This study looks at whether transferring a frozen embryo on day 6 or day 7 of progesterone treatment leads to more live births. It includes 316 women aged 18-43 who have at least one high-quality, genetically normal embryo. Researchers will track pregnancy and miscarriage rates t…

This study tests whether a benchtop incubator helps more embryos reach the blastocyst stage compared to a standard box incubator in people undergoing IVF. 252 participants will have their eggs split and placed in both incubators. The goal is to see which device supports better em…

This study records 30-second videos of embryos from 1,000 IVF patients and uses artificial intelligence to analyze their movement patterns. The goal is to see if these patterns can predict whether an embryo will lead to a successful pregnancy. Participants receive standard care a…

This study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers collect health data, biospecimens, and environmental information to understand how parents' exposures affect pregnancy outcomes and child development. The goal is to f…

This study looks at freezing ovarian tissue in girls with Turner syndrome, a condition that often causes early ovary failure and infertility. Researchers want to find out which patients are most likely to have healthy eggs in their tissue by checking their genes, hormones, and me…

This study investigates how obesity-related factors like high insulin and fat levels may disrupt fertility in women. Researchers will measure hormone changes and metabolic responses in 84 women. The goal is to understand the underlying causes and inform future treatments to impro…

This study follows 1,500 Asian women using REKOVELLE for the first time during IVF to see how well it works in everyday medical practice. Researchers will track live birth rates and how the drug is used. The goal is to understand its real-world effectiveness and safety for this s…

This observational study follows 2000 women aged 40 or younger with breast cancer to see how having a baby after diagnosis affects their survival and disease return. It also checks the growth and health of their children. The goal is to gather information, not to test a new treat…

This study watches embryos grow using time-lapse cameras and compares their development to genetic test results. Researchers hope to find visual clues that indicate a healthy embryo. 2000 IVF patients are taking part. If a link is found, it could lead to a less invasive way to ch…

This study tests a text-messaging program that sends reminders and educational videos to people starting fertility testing. The goal is to see if it helps them complete all the required tests faster. About 160 new female patients at Penn Fertility Care will take part, and half wi…

This study explores whether a woman's pain threshold, measured before the procedure, can predict how much anesthesia she will need during egg retrieval for IVF. Researchers will measure pain thresholds in 30 women and track the amount of sedatives they use. The goal is to persona…

This study looks at how the process of diagnosing infertility affects the sexuality of couples. Researchers will survey 80 heterosexual couples to see if the diagnosis and testing cause sexual problems. The goal is to better understand the link between infertility and sexual heal…

This study was designed to see how a hormone called GnRH is processed by the body when given through a small pump (OmniPod) instead of a needle. It was meant for healthy women aged 18 to 40 with regular periods. However, the trial was withdrawn before any participants were enroll…

This study uses machine learning to analyze data from 5,000 IVF patients to identify patterns that predict successful pregnancy. Researchers hope to create a tool that helps doctors personalize treatments, improving success rates and reducing the emotional and financial burden on…

This study was designed to see if a new monitoring algorithm could detect early signs of ovarian damage in women and girls who had cancer treatment. Researchers planned to compare a group using the new algorithm with a group that received standard care. However, the study was wit…