Immunodeficiency disease
MONDO:0021094Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Also known as: immuno-deficiency, immunodeficiency, immunodeficiency disorder, immunodeficiency syndrome
776 clinical trials for this condition and its sub-types, 55 tagged with Immunodeficiency disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Immunodeficiency disease
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T-cell immunodeficiency 4 trials · 484 incl. sub-types
3 sub-types
- AIDS 463 trials
- Congenital T-cell immunodeficiency 0 trials · 13 incl. sub-types Sub-types →
- Idiopathic CD4-positive T-lymphocytopenia 6 trials
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B cell deficiency 5 trials · 85 incl. sub-types
5 sub-types
- Agammaglobulinemia 16 trials · 52 incl. sub-types Sub-types →
- Hyperimmunoglobulin syndrome 0 trials · 33 incl. sub-types Sub-types →
- Selective immunoglobulin deficiency disease 1 trial · 4 incl. sub-types Sub-types →
- PAX5-related B lymphopenia and autism spectrum disorder 0 trials
- Immunoglobulin beta deficiency 0 trials
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Combined immunodeficiency 3 trials · 57 incl. sub-types
33 sub-types
- Severe combined immunodeficiency 24 trials · 37 incl. sub-types Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Wiskott-Aldrich syndrome 10 trials
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia 2 trials
- Combined immunodeficiency due to CRAC channel dysfunction 1 trial Sub-types →
- Combined immunodeficiency due to ZAP70 deficiency 1 trial
- Non-SCID combined immunodeficiency 0 trials · 1 incl. sub-types Sub-types →
- IRF4-related combined immunodeficiency 0 trials
- MHC class I deficiency 0 trials Sub-types →
- NFATC1-related combined immunodeficiency 0 trials
- POLD3-related combined immunodeficiency 0 trials
- RAC2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome 0 trials Sub-types →
- Autosomal dominant combined immunodeficiency due to ERBIN deficiency 0 trials
- Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to IL6R deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Combined immunodeficiency due to CD3gamma deficiency 0 trials
- Combined immunodeficiency due to CTPS1 deficiency 0 trials
- Combined immunodeficiency due to GINS1 deficiency 0 trials
- Combined immunodeficiency due to MALT1 deficiency 0 trials
- Combined immunodeficiency due to OX40 deficiency 0 trials
- Combined immunodeficiency due to POLE2 deficiency 0 trials
- Combined immunodeficiency due to RELA haploinsufficiency 0 trials
- Combined immunodeficiency due to STK4 deficiency 0 trials
- Combined immunodeficiency due to TBX1 deficiency 0 trials
- Combined immunodeficiency due to dimerization defective IKAROS mutation 0 trials
- Combined immunodeficiency due to moesin deficiency 0 trials
- Combined immunodeficiency syndrome 0 trials Sub-types →
- Combined immunodeficiency with low Ig due to BCL10 deficiency 0 trials
- Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to IKBKA deficiency 0 trials
- Early-onset combined immunodeficiency with low ig due to dominant negative IKAROS mutation 0 trials
- Late-onset combined immunodeficiency due to ICOSL deficiency 0 trials
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Complement deficiency 2 trials · 28 incl. sub-types
8 sub-types
- Atypical hemolytic-uremic syndrome 19 trials Sub-types →
- Classic complement early component deficiency 0 trials · 7 incl. sub-types Sub-types →
- Disorder of lectin complement activation pathway 0 trials · 1 incl. sub-types Sub-types →
- Complement factor I deficiency 0 trials
- Complement receptor deficiency 0 trials
- Immunodeficiency due to a classical component pathway complement deficiency 0 trials Sub-types →
- Immunodeficiency due to a late component of complement deficiency 0 trials Sub-types →
- Recurrent Neisseria infections due to factor D deficiency 0 trials
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X-linked lymphoproliferative syndrome 7 trials · 11 incl. sub-types
2 sub-types
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GATA2 deficiency with susceptibility to MDS/AML 5 trials · 8 incl. sub-types
2 sub-types
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Idiopathic CD4 lymphocytopenia 7 trials
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IKBKG-related immunodeficiency with or without ectodermal dysplasia 0 trials · 4 incl. sub-types
3 sub-types
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IRF4-related immune disorder 1 trial
2 sub-types
- IRF4-related combined immunodeficiency 0 trials
- Immunodeficiency 131 0 trials
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Immunodeficiency 23 1 trial
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Immunodeficiency 31B 1 trial
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DOCK2 deficiency 0 trials
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FADD-related immunodeficiency 0 trials
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FASLG-related immunodeficiency 0 trials
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FNIP1-associated syndrome 0 trials
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Shwachman-Diamond syndrome 1 0 trials
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TNFRSF9-related immunodeficiency 0 trials
1 sub-type
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Wiskott-Aldrich syndrome 2 0 trials
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Hatipoglu immunodeficiency syndrome 0 trials
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Hypoproteinemia, hypercatabolic 0 trials
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Immunodeficiency 102 0 trials
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Immunodeficiency 112 0 trials
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Immunodeficiency 117 0 trials
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Immunodeficiency 118 0 trials
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Immunodeficiency 119 0 trials
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Immunodeficiency 122 0 trials
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Immunodeficiency 125 0 trials
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Immunodeficiency 127 0 trials
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Immunodeficiency 128 0 trials
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Immunodeficiency 132b 0 trials
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Immunodeficiency 15a 0 trials
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Immunodeficiency 35 0 trials
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Immunodeficiency 45 0 trials
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Immunodeficiency 53 0 trials
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Immunodeficiency 57 0 trials
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Immunodeficiency 60 0 trials
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Immunodeficiency 62 0 trials
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Immunodeficiency 64 0 trials
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Immunodeficiency 66 0 trials
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Immunodeficiency 67 0 trials
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Immunodeficiency 69 0 trials
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Immunodeficiency 70 0 trials
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Immunodeficiency 75 0 trials
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Immunodeficiency 76 0 trials
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Immunodeficiency 77 0 trials
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Immunodeficiency 81 0 trials
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Immunodeficiency 84 0 trials
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Immunodeficiency 85 and autoimmunity 0 trials
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Immunodeficiency 86 0 trials
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Immunodeficiency 87 and autoimmunity 0 trials
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Immunodeficiency 88 0 trials
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Immunodeficiency 89 and autoimmunity 0 trials
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Immunodeficiency 92 0 trials
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Immunodeficiency 95 0 trials
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Immunodeficiency 96 0 trials
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Lymphoproliferative syndrome 1 0 trials
Most studied deeper sub-types
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Can a stem cell transplant fix a rare genetic immune disorder?
Disease control Recruiting nowThis study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 with GATA2 mutations will receive chemotherapy or radiation before t…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Donor immune cells aim to fight virus in vulnerable patients
Disease control Recruiting nowThis early-stage trial tests whether specially grown donor T cells can safely treat adenovirus infections in people with weakened immune systems, such as cancer patients. The cells are designed to target and kill the virus. The study will check for side effects and see if the inf…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Can specially grown immune cells from donors beat viruses that won't go away?
Disease control Recruiting nowThis early-phase trial is testing whether immune cells called R-MVST cells, grown quickly from a healthy donor, can safely fight off stubborn viral infections (EBV, CMV, adenovirus, or BK virus) in children and young adults with weakened immune systems. Participants have not resp…
Phase 1 • Sponsor: Monica Bhatia • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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New radiation treatment shows promise for skin cancer in immunocompromised patients
Disease control Recruiting nowThis study tests a new type of radiation therapy called DaRT for people with a common skin cancer (squamous cell carcinoma) who have weakened immune systems. The treatment involves placing tiny radioactive seeds directly into the tumor to kill cancer cells from the inside. Resear…
Sponsor: Alpha Tau Medical LTD. • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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Could a stem cell transplant tame VEXAS syndrome?
Disease control Recruiting nowThis study tests whether a stem cell transplant from a donor can help people with VEXAS syndrome, a rare autoinflammatory disease. Participants receive donor stem cells after drugs to prepare their bone marrow. The goal is to see if the transplant can reverse symptoms and allow p…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New stem cell processing method offers hope for patients without a perfect donor match
Disease control Expanded accessThis expanded access protocol provides stem cell transplants for people with serious blood diseases like leukemia, bone marrow failure, or immune deficiencies who do not have a fully matched sibling donor. The donated stem cells are processed to remove certain immune cells (alpha…
Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Second chance: milder prep for stem cell transplants may help when first fails
Disease control Recruiting nowThis trial tests a second stem cell transplant using a gentler conditioning regimen of busulfan, fludarabine, and low-dose total body irradiation. It is for people with blood disorders, hemoglobin diseases, or immune deficiencies whose first transplant did not achieve enough dono…
Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New hope for immunocompromised patients with severe parainfluenza
Disease control Recruiting nowThis study tests an experimental drug called DAS181 in people with weakened immune systems who have a serious lung infection caused by parainfluenza virus. The goal is to see if the drug helps them breathe without extra oxygen and reduces the risk of death. About 274 participants…
Phase 3 • Sponsor: Ansun Biopharma, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New immune cell boost may shield kids from Post-Transplant infections
Disease control Recruiting nowThis study tests whether adding memory immune cells (CD45RO) to a stem cell transplant can help children fight off dangerous viral and fungal infections after the procedure. The transplant uses donor stem cells that have been stripped of certain cells to prevent graft-versus-host…
Phase 1/2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Double transplant aims to cure diabetes in kids with weak immune systems
Disease control Recruiting nowThis study tests a two-step transplant for children with type 1 diabetes who also have an immune deficiency. First, they receive umbilical cord blood stem cells to rebuild their immune system. Then, if that works well, they get a transplant of insulin-producing islet cells. The g…
Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Could longer or stronger antivirals beat COVID in vulnerable patients?
Disease control Recruiting nowThis study looks at whether giving a longer course (10 days instead of 5) or adding another antiviral (remdesivir) to the standard Paxlovid treatment helps immunocompromised people clear COVID-19 faster. About 256 adults with mild or no symptoms will be randomly assigned to diffe…
Phase 2 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New stem cell transplant option for patients without a perfect donor match
Disease control Recruiting nowThis expanded access program offers a stem cell transplant using donor cells that have been specially processed to remove certain immune cells, reducing the risk of graft-versus-host disease. It is for patients with serious blood disorders, immune deficiencies, or metabolic disea…
Early phase 1 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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New trial aims to boost COVID-19 protection for vulnerable patients
Disease control Recruiting nowThis study is testing whether giving a longer course of the antiviral Paxlovid (10 days instead of 5) or combining it with another antiviral (remdesivir) helps immunocompromised people clear COVID-19 faster. About 256 participants with mild to moderate COVID-19 and weakened immun…
Phase 2 • Sponsor: Calmy Alexandra • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New IVIG therapy V-IMMUNE tested in phase III trial for immune deficiency
Disease control Recruiting nowThis phase III trial tests V-IMMUNE, an intravenous immunoglobulin (IVIG) product, in about 50 people with primary immunodeficiency (PID). Participants, aged 2 and older, will switch from their current IVIG to V-IMMUNE every three weeks for a year. The study aims to see if V-IMMU…
Phase 3 • Sponsor: On Pharma Importadora, Exportadora e Distribuidora de Medicamentos LTDA. • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New transplant approach aims to fix broken immune systems
Disease control Recruiting nowThis phase 2 trial is testing a stem cell transplant using a milder chemotherapy regimen to treat people with severe immune deficiencies and inherited bone marrow failure. The goal is to see if donor cells can safely take over and rebuild a healthy immune system. Up to 27 partici…
Phase 2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Half-Matched stem cells give bone marrow a jump start for High-Risk patients
Disease control Expanded accessThis program offers extra stem cells from a half-matched family donor to patients who are getting a cord blood transplant for serious blood cancers or immune disorders. The goal is to help the bone marrow recover more quickly while the cord blood cells take over permanently. It i…
Sponsor: Joanne Kurtzberg, MD • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Scientists hunt for genetic clues to mysterious immune diseases
Knowledge-focused Recruiting nowThis study aims to find the genetic causes of inherited immune problems that affect white blood cells called lymphocytes. Researchers will review medical records and collect blood samples from up to 5,000 people with suspected immune disorders, as well as their relatives. The goa…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Massive gene hunt aims to unlock secrets of immune disorders
Knowledge-focused Recruiting nowThis study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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NIH launches major screening study to unravel mysteries of immune weakness
Knowledge-focused Recruiting nowThis study screens up to 2,000 people who have or may have immune disorders that make them prone to infections, along with their healthy relatives. Researchers will use medical history, physical exams, blood tests, and genetic testing to better understand these conditions. The go…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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NIH launches massive study to unlock HIV's secrets through blood
Knowledge-focused Recruiting nowThis study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Massive study aims to unlock secrets of immune system diseases
Knowledge-focused Recruiting nowThis study aims to learn more about primary immunodeficiency disorders (PIDs), which weaken the immune system and make people more prone to infections. Researchers will compare genetic and health data from people with PIDs, their healthy relatives, and healthy volunteers to find …
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Cancer samples sought to unlock treatment secrets
Knowledge-focused Recruiting nowThis study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn more about how cancers behave and why some respond differently to treatments. Participants provide samples over time and …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Scientists seek genetic clues to mysterious immune defects
Knowledge-focused Recruiting nowThis study looks at people with unusual or repeated infections and their family members to find the genetic and biochemical causes of immune system problems. Researchers will collect blood, saliva, urine, and other samples over time to better understand these conditions. The goal…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Rapid test may speed up right antibiotics for pneumonia in vulnerable ICU patients
Knowledge-focused Recruiting nowThis study tests whether a rapid PCR test can help doctors choose the right antibiotics within 24 hours for immunocompromised ICU patients with pneumonia. Standard lab tests take days, which can lead to incorrect or overly broad antibiotics. The trial involves 31 adults with weak…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Can a simple tool give kids a voice in their own transplant care?
Knowledge-focused Recruiting nowThis study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. The goal is to see if the tool is easy to use and helpful for families. About 60 …
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC
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Elderly ICU Patients' immune paralysis linked to pneumonia risk
Knowledge-focused Recruiting nowThis study watches 170 ICU patients on breathing machines to see if a temporary immune system weakness (called immunoparalysis) raises the chance of getting pneumonia. Researchers will measure immune markers in elderly patients (65+), younger adults, and healthy volunteers. The g…
Sponsor: Hospital Universitari de Bellvitge • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Scientists hunt for hidden genes behind immune system failures
Knowledge-focused Recruiting nowThis study aims to find new genetic causes of primary immunodeficiency, a condition where the immune system doesn't work properly, leading to frequent or severe infections. Researchers will compare the genes of 500 people with suspected immunodeficiency, their relatives, and heal…
Sponsor: University Children's Hospital, Zurich • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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New study to reveal hidden weaknesses in vaccines for Immune-Compromised patients
Knowledge-focused Recruiting nowThis study looks at how well vaccines against respiratory viruses (like flu or COVID-19) work in people with weakened immune systems, including those with blood cancers. Researchers will measure both antibody and T cell responses after vaccination. The goal is to understand why v…
Sponsor: University of Cologne • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Massive data hunt aims to unlock secrets of stem cell transplants
Knowledge-focused Recruiting nowThis study gathers basic health information from 2000 people receiving stem cell transplants for blood cancers or immune disorders. The goal is to track survival and complications to help doctors and researchers improve future treatments. Participants must be getting a standard t…
Sponsor: Wake Forest University Health Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Should you get your COVID and flu shots together? new study aims to find out for immunocompromised patients
Knowledge-focused Recruiting nowThis study is testing whether giving the COVID-19 booster and flu vaccine at the same time is as good as giving them a month apart for people with weakened immune systems. It also compares getting a COVID-19 booster every 3 months versus every 6 months. The trial involves 660 adu…
Phase 2 • Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Massive study seeks genetic roots of allergies and immune problems
Knowledge-focused Recruiting nowThis study aims to find the genetic causes behind certain allergic and immune system disorders. Researchers will collect blood, saliva, and tissue samples from up to 10,000 people of all ages, along with some family members. No treatments are given; the goal is simply to learn mo…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Scientists probe nose immunity in vulnerable patients
Knowledge-focused Recruiting nowThis observational study will compare nasal immune responses to respiratory viruses like SARS-CoV-2 in 40 adults, including immunocompromised patients and healthy volunteers. Researchers aim to understand how underlying conditions and treatments affect immune cell activity in the…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Parkinson's drug may weaken immunity: new study investigates
Knowledge-focused Recruiting nowThis study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…
Phase 4 • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Scientists investigate why some diabetic foot ulcers never heal
Knowledge-focused Recruiting nowThis observational study will compare blood and tissue samples from 40 diabetic patients with foot ulcers. Researchers want to understand how immune cells differ between people whose ulcers heal and those whose ulcers do not. The goal is to identify specific immune cell patterns …
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:53 UTC