Monocytopenia with susceptibility to infections
MONDO:0013607Also known as: MonoMAC, immunodeficiency type 21, monocytopenia and mycobacterial infection syndrome, DCML, Dendritic cell, monocyte, B lymphocyte, and natural Killer lymphocyte deficiency, GATA2 deficiency, IMD21, combined immunodeficiency with susceptibility to mycobacterial, viral, and fungal infections
5 clinical trials for this condition and its sub-types, 5 tagged with Monocytopenia with susceptibility to infections itself.
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Can a stem cell transplant fix a rare genetic immune disorder?
Disease control Recruiting nowThis study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 with GATA2 mutations will receive chemotherapy or radiation before t…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Massive gene hunt aims to unlock secrets of immune disorders
Knowledge-focused Recruiting nowThis study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Stem cells harvested for lab tests in immune disorder gene therapy quest
Knowledge-focused Recruiting nowThis study collects blood stem cells from adults aged 18-40 with DOCK8 deficiency, LAD-1, or GATA2 deficiency. Participants receive daily injections of G-CSF for 5 days to move stem cells into the blood, then undergo a single leukapheresis procedure to collect them. The cells are…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC