Hereditary skin disorder
MONDO:0100118An instance of skin disease that is caused by a modification of the individual's genome.
Also known as: disease, genetic skin, diseases, genetic skin, genetic skin disease, genetic skin diseases, genodermatosis, skin disease, genetic
885 clinical trials for this condition and its sub-types, 7 tagged with Hereditary skin disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hereditary skin disorder
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Psoriasis 381 trials
3 sub-types
- Pustular psoriasis 6 trials · 39 incl. sub-types Sub-types →
- Guttate psoriasis 2 trials
- Psoriasis 2 0 trials
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Acne 92 trials
1 sub-type
- Adult acne 0 trials
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Hereditary angioedema 58 trials · 60 incl. sub-types
10 sub-types
- Hereditary angioedema with C1Inh deficiency 14 trials · 32 incl. sub-types Sub-types →
- Hereditary angioedema type 3 2 trials
- Hereditary angioedema with normal C1Inh 2 trials
- PLG-related hereditary angioedema with normal C1inh 0 trials
- Angioedema, hereditary, 4 0 trials
- Angioedema, hereditary, 5 0 trials
- Angioedema, hereditary, 6 0 trials
- Angioedema, hereditary, 7 0 trials
- Angioedema, hereditary, 8 0 trials
- Hereditary angioedema with normal C1inh not related to F12 or PLG variant 0 trials
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Ectodermal dysplasia syndrome 3 trials · 45 incl. sub-types
120 sub-types
- Dyskeratosis congenita 12 trials Sub-types →
- CTSC-related disorder 0 trials · 11 incl. sub-types Sub-types →
- Cardiofaciocutaneous syndrome 7 trials Sub-types →
- Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 4 trials
- Incontinentia pigmenti 3 trials
- Ectodermal dysplasia WNT10A related 0 trials · 2 incl. sub-types Sub-types →
- Trichothiodystrophy 2 trials Sub-types →
- Cronkhite-Canada syndrome 1 trial
- Ellis-van Creveld syndrome 1 trial Sub-types →
- Cartilage-hair hypoplasia 1 trial Sub-types →
- Hypohidrotic ectodermal dysplasia 1 trial Sub-types →
- Trichorhinophalangeal syndrome 0 trials · 1 incl. sub-types Sub-types →
- ADULT syndrome 0 trials
- AREDYLD syndrome 0 trials
- Ackerman syndrome 0 trials
- Barber-Say syndrome 0 trials
- Bartsocas-Papas syndrome 1 0 trials
- Brunoni syndrome 0 trials
- Böök syndrome 0 trials
- CHIME syndrome 0 trials
- Clouston syndrome 0 trials
- Curly hair - acral keratoderma - caries syndrome 0 trials
- Dahlberg-Borer-Newcomer syndrome 0 trials
- Dubowitz syndrome 0 trials
- EEM syndrome 0 trials
- Fontaine progeroid syndrome 0 trials
- Fried's tooth and nail syndrome 0 trials
- GAPO syndrome 0 trials
- Ito hypomelanosis 0 trials
- Johnson neuroectodermal syndrome 0 trials
- KID syndrome 0 trials Sub-types →
- Lelis syndrome 0 trials
- Leukomelanoderma-infantilism-intellectual disability-hypodontia-hypotrichosis syndrome 0 trials
- Marshall syndrome 0 trials
- Naegeli-Franceschetti-Jadassohn syndrome 0 trials
- Rapp-Hodgkin syndrome 0 trials
- Schinzel-Giedion syndrome 0 trials
- Stern-Lubinsky-Durrie syndrome 0 trials
- Teebi-Shaltout syndrome 0 trials
- Toriello-Lacassie-Droste syndrome 0 trials
- Acrofacial dysostosis, Weyers type 0 trials
- Alopecia - contractures - dwarfism - intellectual disability syndrome 0 trials
- Alves Castelo dos Santos syndrome 0 trials
- Amelocerebrohypohidrotic syndrome 0 trials
- Ameloonychohypohidrotic syndrome 0 trials
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome 0 trials Sub-types →
- Anonychia with flexural pigmentation 0 trials
- Arrhythmogenic cardiomyopathy with wooly hair and keratoderma 0 trials
- Arthrogryposis-ectodermal dysplasia-other anomalies syndrome 0 trials
- Autosomal dominant palmoplantar keratoderma and congenital alopecia 0 trials
- Autosomal dominant trichoodontoonychodysplasia-syndactyly 0 trials
- Autosomal recessive palmoplantar keratoderma and congenital alopecia 0 trials
- Blepharocheilodontic syndrome 0 trials Sub-types →
- Cataract-hypertrichosis-intellectual disability syndrome 0 trials
- Cerebellar ataxia-ectodermal dysplasia syndrome 0 trials
- Chondroectodermal dysplasia with night blindness 0 trials
- Choroidal atrophy-alopecia syndrome 0 trials
- Circumscribed palmoplantar hypokeratosis 0 trials
- Cleft lip/palate-ectodermal dysplasia syndrome 0 trials
- Conductive deafness-ptosis-skeletal anomalies syndrome 0 trials
- Congenital hypotrichosis with juvenile macular dystrophy 0 trials
- Contractures-ectodermal dysplasia-cleft lip/palate syndrome 0 trials
- Cranioectodermal dysplasia 0 trials Sub-types →
- Dermatoosteolysis, Kirghizian type 0 trials
- Dermatopathia pigmentosa reticularis 0 trials
- Dermo-odonto dysplasia 0 trials
- Dermotrichic syndrome 0 trials
- Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 0 trials
- Ectodermal dysplasia 13, hair/tooth type 0 trials
- Ectodermal dysplasia 14, hair/tooth type with or without hypohidrosis 0 trials
- Ectodermal dysplasia 15, hypohidrotic/hair type 0 trials
- Ectodermal dysplasia 17 with or without limb malformations 0 trials
- Ectodermal dysplasia 5, hair/nail type 0 trials
- Ectodermal dysplasia Bartalos type 0 trials
- Ectodermal dysplasia alopecia preaxial polydactyly 0 trials
- Ectodermal dysplasia arthrogryposis diabetes mellitus 0 trials
- Ectodermal dysplasia blindness 0 trials
- Ectodermal dysplasia margarita type 0 trials
- Ectodermal dysplasia neurosensory deafness 0 trials
- Ectodermal dysplasia with natal teeth, Turnpenny type 0 trials
- Ectodermal dysplasia, trichoodontoonychial type 0 trials
- Ectodermal dysplasia-blindness syndrome 0 trials
- Ectodermal dysplasia-intellectual disability-central nervous system malformation syndrome 0 trials
- Ectodermal dysplasia-sensorineural deafness syndrome 0 trials
- Ectodermal dysplasia-syndactyly syndrome 0 trials Sub-types →
- Epidermolysis bullosa simplex due to plakophilin deficiency 0 trials
- Focal facial dermal dysplasia 0 trials Sub-types →
- Gingival fibromatosis-hypertrichosis syndrome 0 trials
- Hidrotic ectodermal dysplasia, Christianson-Fourie type 0 trials
- Hidrotic ectodermal dysplasia, Halal type 0 trials
- Hypertrichosis cubiti-short stature syndrome 0 trials
- Hypertrichosis lanuginosa congenita 0 trials Sub-types →
- Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome 0 trials
- Hypotrichosis-osteolysis-periodontitis-palmoplantar keratoderma syndrome 0 trials
- Ichthyosis-alopecia-eclabion-ectropion-intellectual disability syndrome 0 trials
- Jones hersh yusk syndrome 0 trials
- Limb-mammary syndrome 0 trials
- Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies 0 trials
- Nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome 0 trials
- Oculodentodigital dysplasia 0 trials Sub-types →
- Oculoosteocutaneous syndrome 0 trials
- Oculotrichodysplasia 0 trials
- Odonto-onycho dysplasia-alopecia syndrome 0 trials
- Odonto-tricho-ungual-digito-palmar syndrome 0 trials
- Odontomicronychial dysplasia 0 trials
- Odontotrichomelic syndrome 0 trials
- Pili torti-onychodysplasia syndrome 0 trials
- Pilodental dysplasia-refractive errors syndrome 0 trials
- Pure hair and nail ectodermal dysplasia 0 trials Sub-types →
- Scalp-ear-nipple syndrome 0 trials
- Taurodontia-absent teeth-sparse hair syndrome 0 trials
- Tooth and nail syndrome 0 trials
- Tricho-dento-osseous syndrome 0 trials
- Tricho-oculo-dermo-vertebral syndrome 0 trials
- Tricho-retino-dento-digital syndrome 0 trials
- Trichodental syndrome 0 trials
- Trichodermodysplasia-dental alterations syndrome 0 trials
- Trichodysplasia-amelogenesis imperfecta syndrome 0 trials
- Trichomegaly-retina pigmentary degeneration-dwarfism syndrome 0 trials
- Trichoodontoonychial dysplasia 0 trials
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Inherited epidermolysis bullosa 5 trials · 38 incl. sub-types
4 sub-types
- Epidermolysis bullosa dystrophica 23 trials · 30 incl. sub-types Sub-types →
- Junctional epidermolysis bullosa 6 trials · 8 incl. sub-types Sub-types →
- Epidermolysis bullosa simplex 6 trials Sub-types →
- Kindler syndrome 0 trials Sub-types →
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CHILD syndrome 37 trials
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Inherited ichthyosis 6 trials · 33 incl. sub-types
13 sub-types
- Netherton syndrome 16 trials
- Autosomal recessive congenital ichthyosis 2 trials · 10 incl. sub-types Sub-types →
- Keratinopathic ichthyosis 0 trials · 7 incl. sub-types Sub-types →
- Ichthyosis vulgaris 3 trials Sub-types →
- Recessive X-linked ichthyosis 2 trials Sub-types →
- Peeling skin syndrome 1 trial Sub-types →
- IFAP syndrome 0 trials Sub-types →
- Congenital cataract-ichthyosis syndrome 0 trials
- Ichthyosis hystrix 0 trials Sub-types →
- Ichthyosis linearis circumflexa 0 trials
- Ichthyosis with erythrokeratoderma 0 trials
- Ichthyosis-oral and digital anomalies syndrome 0 trials
- Neonatal ichthyosis-sclerosing cholangitis syndrome 0 trials
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Hereditary photodermatosis 0 trials · 31 incl. sub-types
6 sub-types
- Inherited porphyria 0 trials · 24 incl. sub-types Sub-types →
- Xeroderma pigmentosum 4 trials · 6 incl. sub-types Sub-types →
- Xeroderma pigmentosum-Cockayne syndrome complex 1 trial · 2 incl. sub-types Sub-types →
- Rothmund-Thomson syndrome 1 trial Sub-types →
- Bloom syndrome 0 trials
- UV-sensitive syndrome 0 trials Sub-types →
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Lichen sclerosus et atrophicus 10 trials · 20 incl. sub-types
1 sub-type
- Vulvar lichen sclerosus 15 trials
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Hereditary lipodystrophy 2 trials · 17 incl. sub-types
11 sub-types
- Familial partial lipodystrophy 13 trials · 14 incl. sub-types Sub-types →
- Congenital generalized lipodystrophy 2 trials · 3 incl. sub-types Sub-types →
- Berardinelli-Seip congenital lipodystrophy 0 trials · 1 incl. sub-types Sub-types →
- Keppen-Lubinsky syndrome 0 trials
- SHORT syndrome 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Lipoatrophy with diabetes, leukomelanodermic papules, liver steatosis, and hypertrophic cardiomyopathy 0 trials
- Lipodystrophy due to peptidic growth factors deficiency 0 trials
- Lipodystrophy-intellectual disability-deafness syndrome 0 trials
- Mandibuloacral dysplasia 0 trials Sub-types →
- Severe neurodegenerative syndrome with lipodystrophy 0 trials
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Hereditary palmoplantar keratoderma 0 trials · 13 incl. sub-types
8 sub-types
- Diffuse palmoplantar keratoderma 0 trials · 12 incl. sub-types Sub-types →
- Olmsted syndrome 1 trial Sub-types →
- Focal palmoplantar keratoderma 0 trials · 1 incl. sub-types Sub-types →
- Palmoplantar keratoderma, epidermolytic 0 trials · 1 incl. sub-types Sub-types →
- Alopecia congenita keratosis palmoplantaris 0 trials
- Palmoplantar keratoderma i, striate, focal, or diffuse 0 trials
- Palmoplantar keratoderma, nonepidermolytic, focal or diffuse 0 trials
- Punctate palmoplantar keratoderma 0 trials Sub-types →
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Familial multiple nevi flammei 12 trials
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Syndromic oculocutaneous albinism 0 trials · 12 incl. sub-types
4 sub-types
- Chediak-Higashi syndrome 9 trials
- Hermansky-Pudlak syndrome 4 trials Sub-types →
- Griscelli syndrome 2 trials · 3 incl. sub-types Sub-types →
- Oculocerebral hypopigmentation syndrome, Cross type 0 trials
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Cowden disease 11 trials
8 sub-types
- Cowden syndrome 1 1 trial
- Cowden syndrome 2 0 trials
- Cowden syndrome 3 0 trials
- Cowden syndrome 4 0 trials
- Cowden syndrome 5 0 trials
- Cowden syndrome 6 0 trials
- Cowden syndrome 7 0 trials
- Sacral hemangiomas multiple congenital abnormalities 0 trials
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Familial pityriasis rubra pilaris 10 trials
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Lentigo 8 trials
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Large congenital melanocytic nevus 7 trials
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Neutrophil actin dysfunction 6 trials
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Seborrheic keratosis 6 trials
5 sub-types
- Eyelid seborrheic keratosis 0 trials
- Inflamed seborrheic keratosis 0 trials
- Inverted follicular keratosis 0 trials Sub-types →
- Melanoacanthoma 0 trials
- Vulvar seborrheic keratosis 0 trials Sub-types →
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Alopecia, isolated 0 trials · 6 incl. sub-types
8 sub-types
- Alopecia universalis congenita 6 trials
- Alopecia areata 1 0 trials
- Alopecia areata 2 0 trials
- Alopecia, androgenetic, 1 0 trials
- Alopecia, androgenetic, 2 0 trials
- Alopecia, androgenetic, 3 0 trials
- Alopecia, congenital 0 trials
- Familial focal alopecia 0 trials
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CLOVES syndrome 5 trials
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Legius syndrome 5 trials
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Reticulate pigment disorder 0 trials · 5 incl. sub-types
3 sub-types
- Dowling-Degos disease 0 trials · 4 incl. sub-types Sub-types →
- Dyschromatosis symmetrica hereditaria 1 trial
- Reticulate acropigmentation of Kitamura 0 trials
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Hailey-Hailey disease 4 trials
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Chronic mucocutaneous candidiasis 4 trials
12 sub-types
- Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome 0 trials
- Candidiasis, familial, 1 0 trials
- Candidiasis, familial, 3 0 trials
- Candidiasis, familial, 4 0 trials
- Candidiasis, familial, 6 0 trials
- Candidiasis, familial, 8 0 trials
- Candidiasis, familial, 9 0 trials
- Chronic mucocutaneous candidiasis due to inhibition of lymphoblastic transformation 0 trials
- Chronic mucocutaneous candidiasis due to intrinsic defect in lymphoblastic transformation 0 trials
- Chronic mucocutaneous candidiasis due to lymphokine deficiency 0 trials
- Chronic mucocutaneous candidiasis due to monocyte chemotactic disorder 0 trials
- Immunodeficiency 51 0 trials
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Lamellar ichthyosis 4 trials
6 sub-types
- Autosomal recessive congenital ichthyosis 6 1 trial
- Autosomal recessive congenital ichthyosis 3 0 trials
- Autosomal recessive congenital ichthyosis 4A 0 trials Sub-types →
- Autosomal recessive congenital ichthyosis 5 0 trials
- Autosomal recessive congenital ichthyosis 8 0 trials
- Ichthyosis, lamellar, autosomal dominant 0 trials
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Oculocutaneous albinism 4 trials
9 sub-types
- Oculocutaneous albinism type 1 0 trials · 1 incl. sub-types Sub-types →
- Autosomal dominant oculocutaneous albinism 0 trials
- Oculocutaneous albinism type 2 0 trials
- Oculocutaneous albinism type 3 0 trials
- Oculocutaneous albinism type 4 0 trials
- Oculocutaneous albinism type 5 0 trials
- Oculocutaneous albinism type 6 0 trials
- Oculocutaneous albinism type 7 0 trials
- Oculocutaneous albinism type 8 0 trials
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Piebaldism 4 trials
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Aplasia cutis congenita 3 trials
3 sub-types
- Aplasia cutis autosomal recessive 0 trials
- Aplasia cutis congenita dominant 0 trials
- Aplasia cutis-myopia syndrome 0 trials
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Hereditary mucosal leukokeratosis 3 trials
2 sub-types
- White sponge nevus 1 0 trials
- White sponge nevus 2 0 trials
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Schwannomatosis 3 trials
4 sub-types
- 22q-related schwannomatosis 0 trials
- LZTR1-related schwannomatosis 0 trials
- SMARCB1-related schwannomatosis 0 trials
- Neurofibromatosis, type III, mixed central and peripheral 0 trials
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Maffucci syndrome 2 trials
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Sneddon syndrome 2 trials
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Blue rubber bleb nevus 2 trials
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Familial chilblain lupus 2 trials
2 sub-types
- Chilblain lupus 1 0 trials
- Chilblain lupus 2 0 trials
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Keratosis pilaris atrophicans 2 trials
4 sub-types
- Atrophoderma vermiculata 0 trials
- Keratosis follicularis spinulosa decalvans 0 trials Sub-types →
- Keratosis pilaris atrophicans faciei 0 trials
- Ulerythema ophryogenesis 0 trials
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Stiff skin syndrome 2 trials
1 sub-type
- Fascial dystrophy, congenital 0 trials
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Sweet syndrome 2 trials
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Darier disease 1 trial
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Tietz syndrome 1 trial
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Acrokeratosis verruciformis 1 trial
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3 sub-types
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3 sub-types
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Linear nevus sebaceous syndrome 1 trial
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Neurocutaneous melanocytosis 1 trial
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Nevus, epidermal 1 trial
1 sub-type
- Wooly hair nevus 0 trials
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Urticaria, aquagenic 1 trial
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Becker nevus syndrome 0 trials
1 sub-type
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Cobb syndrome 0 trials
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H syndrome 0 trials
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MEDNIK syndrome 0 trials
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PENS syndrome 0 trials
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Acrogeria 0 trials
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Albinism-hearing loss syndrome 0 trials
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1 sub-type
- Wrinkly skin syndrome 0 trials
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Dermatitis herpetiformis, familial 0 trials
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Dermatosis papulosa nigra 0 trials
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Encephalocraniocutaneous lipomatosis 0 trials
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Epidermodysplasia verruciformis 0 trials
1 sub-type
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Familial acanthosis nigricans 0 trials
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Familial acne inversa 0 trials
3 sub-types
- Acne inversa, familial, 1 0 trials
- Acne inversa, familial, 2 0 trials
- Acne inversa, familial, 3 0 trials
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Familial keratoacanthoma 0 trials
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Familial multiple discoid fibromas 0 trials
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Familial multiple fibrofolliculoma 0 trials
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Hereditary mucoepithelial dysplasia 0 trials
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Hydroa vacciniforme, familial 0 trials
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1 sub-type
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Isolated congenital adermatoglyphia 0 trials
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Isolated hyperchlorhidrosis 0 trials
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Juvenile hyaline fibromatosis 0 trials
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Lichen planus, familial 0 trials
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Lipoid proteinosis 0 trials
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Monilethrix 0 trials
3 sub-types
- Monilethrix-1 0 trials
- Monilethrix-2 0 trials
- Monilethrix-3 0 trials
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2 sub-types
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Nevus comedonicus syndrome 0 trials
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Phakomatosis pigmentokeratotica 0 trials
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Pilomatrixoma 0 trials
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Poikiloderma with neutropenia 0 trials
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Porokeratosis 0 trials
4 sub-types
- Disseminated superficial actinic porokeratosis 0 trials Sub-types →
- Linear porokeratosis 0 trials
- Porokeratosis of Mibelli 0 trials Sub-types →
- Porokeratosis plantaris palmaris et disseminata 0 trials
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Progressive osseous heteroplasia 0 trials
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Sebocystomatosis 0 trials
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Spinocerebellar ataxia type 34 0 trials
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Vasculitis, lymphocytic, nodular 0 trials
Most studied deeper sub-types
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Immune cells take on nerve tumors: new trial launches
Disease control Stopped earlyThis early-stage trial is testing whether specially engineered immune cells (called CAR-T and CTL cells) and a dendritic cell vaccine can safely treat people with neurofibromatosis or schwannomatosis, conditions that cause nerve tumors. The study will enroll 100 participants aged…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Could a daily pill stop hereditary angioedema attacks?
Disease control Stopped earlyThis trial tests whether an experimental oral medication, deucrictibant, can reduce the number of swelling attacks in people with hereditary angioedema (HAE) types I and II. Participants take either a low or high dose of the drug or a placebo for 12 weeks, and then may continue o…
Phase 2 • Sponsor: Pharvaris Netherlands B.V. • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Can a gel tame psoriasis? new antibody fragment put to the test
Disease control Stopped earlyThis phase 2 trial is testing whether a topical gel containing ZL-1102, an antibody fragment that blocks IL-17A, can safely and effectively reduce the severity of chronic plaque psoriasis. The study enrolls adults with psoriasis for at least six months and compares different dose…
Phase 2 • Sponsor: Zai Lab (Hong Kong), Ltd. • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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New injection aims to stop dangerous psoriasis flares in their tracks
Disease control Stopped earlyThis phase 2 trial tests an injection called TQH2929, a lab-made antibody that blocks inflammation, in 36 adults having a sudden, severe flare of generalized pustular psoriasis (GPP). Half get the drug, half get a placebo. The main goal is to see if the drug clears pustules withi…
Phase 2 • Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Psoriasis patients switch biologics in new Real-World study
Disease control Stopped earlyThis study watches 200 adults with moderate to severe psoriasis who switch from ustekinumab to guselkumab in everyday medical practice. Researchers track how well the new drug clears skin symptoms and check for side effects over 52 weeks. The goal is to see if guselkumab works sa…
Sponsor: Janssen-Cilag Ltd. • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Could a gel cut down on skin cancer surgeries? new trial investigates
Disease control Stopped earlyThis trial tests a gel called patidegib applied to the face twice daily for 9 months in people who develop many basal cell carcinomas (a common skin cancer) but do not have Gorlin syndrome. The goal is to see if the gel reduces the number of new skin cancers that would normally r…
Phase 2 • Sponsor: Sol-Gel Technologies, Ltd. • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Laser plus gel: new hope for port wine stains?
Disease control Stopped earlyThis study tested whether adding timolol gel to pulsed dye laser treatment could improve results for port wine stains on children's faces. Twenty-five children aged 6 months to 18 years were enrolled, but the study was stopped early. The goal was to see if the combination led to …
Phase 3 • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Experimental drug for rare skin disease fails to reach goal
Disease control Stopped earlyThis early-stage trial tested a drug called DS-2325a in 9 adults with Netherton syndrome, a rare genetic condition causing severe skin redness, scaling, and allergies. The study aimed to check safety and whether the drug could help control the disease. However, the trial was term…
Phase 1/2 • Sponsor: Daiichi Sankyo • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New daily pill aims to stop HAE attacks, but trial cut short
Disease control Stopped earlyThis phase 2 trial tested KVD824, an oral pill, to prevent swelling attacks in people with hereditary angioedema types I and II. The study planned to compare three doses against a placebo over several months. However, the trial was terminated early with only 33 participants, so t…
Phase 2 • Sponsor: KalVista Pharmaceuticals, Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Promising drug for hand and foot blisters falls short in early trial
Disease control Stopped earlyThis study tested a daily pill called deucravacitinib in 3 adults with palmoplantar pustulosis (PPP), a painful skin condition causing blisters on palms and soles. The goal was to see if the drug could reduce disease severity by at least 50% over 24 weeks. However, the trial was …
Phase 4 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Promising psoriasis drug trial halted early – what now?
Disease control Stopped earlyThis study tested a drug called imsidolimab for adults with generalized pustular psoriasis (GPP), a rare and painful skin condition. The trial aimed to see if the drug is safe and works over the long term. However, the study was terminated early, so we have less information than …
Phase 3 • Sponsor: Vanda Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New drug hope for painful hand and foot pustules
Disease control Stopped earlyThis trial tested the drug deucravacitinib in people with moderate-to-severe palmoplantar pustulosis, a skin condition causing painful pustules on the palms and soles. The study planned to enroll 25 participants who would take the drug daily for 16 weeks, but it was terminated ea…
Sponsor: Peking University First Hospital • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Hope for rare skin disease: new drug shows promise in trial
Disease control Stopped earlyThis study tested a medicine called spesolimab for people with Netherton syndrome, a rare genetic skin condition causing severe redness and scaling. About 43 people aged 12 and older took part, receiving either the drug or a placebo. The goal was to see if spesolimab could reduce…
Phase 2/3 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Experimental drug XmAb27564 tested for skin conditions – trial halted early
Disease control Stopped earlyThis early-stage trial tested an experimental drug called XmAb27564 in 23 people with mild-to-severe plaque psoriasis or moderate-to-severe atopic dermatitis. Participants received four doses of the drug or a placebo every two weeks. The main goal was to check safety and tolerabi…
Phase 1 • Sponsor: Xencor, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Psoriasis combo therapy trial ends early: what happened?
Disease control Stopped earlyThis study tested whether adding low-dose methotrexate to standard anti-TNF therapy could improve and extend the response in adults with moderate to severe psoriasis. The trial planned to enroll 78 participants but was terminated early. The main goal was to see how long patients …
Phase 4 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Cream combo tested for scalp bumps in men of african descent
Disease control Stopped earlyThis study tested Duobrii, a prescription cream that combines a strong steroid with a retinoid, for treating early-mild acne keloidalis nuchae (AKN) — a chronic scalp condition causing bumps and scarring, mainly in men of African descent. The trial planned to enroll 15 adults wit…
Phase 3 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Spesolimab shows promise for Long-Term control of painful hand and foot pustules
Disease control Stopped earlyThis study looks at the long-term safety of spesolimab for people with palmoplantar pustulosis, a chronic skin condition causing painful pustules on hands and feet. Participants who benefited from spesolimab in earlier trials can continue treatment for up to 5 years, with monthly…
Phase 2 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Experimental drug targets rare fat Disorder's metabolic woes
Disease control Stopped earlyThis phase 2 trial tested a drug called REGN4461 (mibavademab) in 20 people with familial partial lipodystrophy, a rare condition causing abnormal fat distribution and metabolic problems. The study aimed to see if the drug could lower high triglycerides and improve blood sugar co…
Phase 2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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AI mole checker tested at home – but trial stops early
Diagnosis Stopped earlyThis study tested whether a device called the Sklip System, which uses artificial intelligence, could help people at home decide if a mole might be skin cancer. Only one person took part before the study was stopped early. The goal was to see if the AI could match or beat standar…
Sponsor: OHSU Knight Cancer Institute • Aim: Diagnosis
Last updated Jun 27, 2026 08:07 UTC
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Porphyria prevention study halted early – little data to go on
Prevention Stopped earlyThis small phase 2 trial tested whether the drug Panhematin could prevent acute attacks in people with certain types of porphyria. Only 13 participants were enrolled before the study was terminated early. Researchers tracked attacks and serious side effects, but the limited data …
Phase 2 • Sponsor: The University of Texas Medical Branch, Galveston • Aim: Prevention
Last updated Jun 27, 2026 09:00 UTC
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Can an eczema drug calm a rare genetic skin disease?
Symptom relief Stopped earlyNetherton syndrome is a rare genetic disorder that causes red, scaly, inflamed skin and intense itching. No targeted treatments exist, so researchers are testing dupilumab, an injectable drug already used for eczema, against a placebo in 10 adults with moderate to severe Netherto…
Phase 2/3 • Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Sep 21, 2026 15:00 UTC
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Nail psoriasis injection study halted after just one person
Symptom relief Stopped earlyThis study tested whether injecting methotrexate directly into the nail area could improve nail psoriasis symptoms like pitting and discoloration. Only one person enrolled before the trial was stopped early. The goal was to measure changes in nail appearance using a severity scor…
Phase 4 • Sponsor: Weill Medical College of Cornell University • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Laser zaps acne? small trial fizzles out
Symptom relief Stopped earlyThis study tested whether a fractional carbon dioxide laser can improve moderate to severe acne in adults aged 18 to 40. Participants received up to 3 laser treatments and were followed for changes in blemish count and skin severity. The trial was terminated early and only enroll…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Can a blood injection boost carpal tunnel surgery results?
Symptom relief Stopped earlyThis study looked at whether adding platelet-rich plasma (PRP) to standard carpal tunnel release surgery helps people with severe carpal tunnel syndrome. The trial planned to enroll 15 adults with severe nerve damage. It compared surgery with PRP to surgery alone. The study was t…
Sponsor: Michael Fredericson, MD • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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Psoriasis drug trial for sensitive areas halted early
Symptom relief Stopped earlyThis study tested the drug deucravacitinib (SOTYKTU) in 130 people with psoriasis on the palms, soles, and genitals. The goal was to see if it improves skin clearance and reduces symptoms. The trial was terminated early, so final results are limited.
Phase 4 • Sponsor: Bristol-Myers Squibb • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Scientists dive into rare cholesterol disorders to uncover clues
Knowledge-focused Stopped earlyThis study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Rare skin disease study seeks to understand netherton syndrome
Knowledge-focused Stopped earlyThis study aimed to collect real-world data on Netherton Syndrome, a rare genetic skin disorder. Researchers planned to follow 4 participants over 52 weeks, measuring skin severity and other symptoms. The study was terminated early, so results are limited.
Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Scientists dive into cells to unravel costello Syndrome's secrets
Knowledge-focused Stopped earlyThis study collects small skin samples from children aged 2 to 17 with Costello syndrome or a related condition. Researchers will analyze the cells to understand how a mutation in the HRAS gene affects energy use and mitochondria. The goal is to learn more about the disease's und…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Yeast study in rare autoimmune disease terminated early
Knowledge-focused Stopped earlyThis study aimed to compare the types of Candida yeast found in patients with two forms of autoimmune polyendocrinopathy, a rare condition where the immune system attacks multiple glands. Researchers planned to collect samples from the mouth and urine of 7 participants to see how…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Scientists hunt for blood clues to tame unpredictable swelling attacks
Knowledge-focused Stopped earlyThis study aimed to find biomarkers (measurable substances in the blood) that could help doctors diagnose bradykinin angioedema and predict how severe attacks might be. The condition causes sudden, unpredictable swelling, and current tests don't work well for all types. Researche…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Superhero training for food allergy safety falls short
Knowledge-focused Stopped earlyThis study aimed to help children aged 6-8 from low-income families learn how to avoid foods they are allergic to. The program used fun, hands-on activities to teach safety skills. The study was stopped early, so we don't have clear results on whether it worked.
Sponsor: Kent State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Insulin's hidden role in psoriasis uncovered
Knowledge-focused Stopped earlyThis study looked at how insulin works in the skin of people with plaque psoriasis who are also overweight or have prediabetes. Researchers took small skin samples from both psoriasis patches and healthy skin to measure insulin activity. The goal was to understand if insulin acts…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC