Progressive osseous heteroplasia

A rare genetic bone disorder characterized clinically by progressive extraskeletal bone formation presenting in early life with cutaneous ossification, that progressively involves subcutaneous and then subsequently deep connective tissues, including muscle and fascia. POH overlaps with a number of related genetic disorders including Albright hereditary osteodystrophy, pseudohypoparathyroidism (see these terms), and primary osteoma cutis, that share the common features of superficial heterotopic ossification in association with inactivating mutations of GNAS gene (20q13.2-q13.3), coding for guanine nucleotide-binding proteins. POH can, however, be distinguished clinically by the deep and progressive nature of the heterotopic bone formation.

Also known as: POH, familial ectopic ossification, poh, ectopic ossification familial type, ectopic ossification, familial, osseous heteroplasia, progressive, osteoma cutis

0 clinical trials for this condition and its sub-types, 0 tagged with Progressive osseous heteroplasia itself.