Nail psoriasis injection study halted after just one person
NCT ID NCT06578728
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether injecting methotrexate directly into the nail area could improve nail psoriasis symptoms like pitting and discoloration. Only one person enrolled before the trial was stopped early. The goal was to measure changes in nail appearance using a severity score.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
1 person
The number who actually took part.
- Started
-
Sep 2025
- Finished
-
Jun 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subject must be at least 18 years of age * Subject must have nail psoriasis that is clinically diagnosed in at least 3 fingernails Exclusion Criteria: * Subject with any clinically significant condition or situation, other than the condition being studied that, in the opinion of the investigator, would interfere with study evaluations or optimal participation in the study. This is including, but not limited to: immunodeficiency, onychomycosis, any other nail condition other than psoriasis, allergy to methotrexate, triamcinolone acetonide, local anesthetic, normal saline, or any other material used for procedures * Subject who has received radiation therapy, chemotherapy, and/or immunosuppressive drugs within 6 months of study, and/or oral corticosteroids or IV methotrexate for \>1 month within the 6 months of study (exception inhaled steroids); * Subjects who use substances (medications, supplements, ect) known to significantly interact with drugs used as intervention in the study * Subject who is pregnant, breastfeeding, or planning to get pregnant * Subject known to have received treatment with investigational drugs or devices within 30 days prior to enrollment into this study * Subject who is on systemic treatment for psoriasis * Subject with baseline abnormalities in liver function tests or complete blood count * Subjects with diagnosis of renal insufficiency or impairment * Subject who is unwilling to abstain from any cosmetic nail treatments outside those provided by the study clinic, beyond basic nail trimming (i.e. no spa nail treatments, no nail polish use, no other topical prescription nail medication) * Subject who is unwilling to abstain from any medical nail treatments on their nails other than the study intervention (i.e. topical steroids, antifungal creams) for the duration of the study intervention and for duration of the washout period (if applicable) * Subject who is part of the staff personnel directly involved with this study or a family member of the investigational study staff
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Nail psoriasis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Israel Englander Department of Dermatology
New York, New York, 10021, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a single cream tackle both skin and nail psoriasis?
- Can a urea cream beat vaseline for nail psoriasis?
- Can a daily patch fix your toenails? new trial aims to find out
- New pill shows promise for nail psoriasis in first human test
- Could a nail polish treat psoriasis? small trial tests tofacitinib lacquer