Could a nail polish treat psoriasis? small trial tests tofacitinib lacquer
NCT ID NCT07313072
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests a daily nail lacquer containing 2% tofacitinib for nail psoriasis. Ten adults with nail psoriasis will apply the lacquer at home for 26 weeks. Researchers will measure changes in nail appearance using the Nail Psoriasis Severity Index and quality of life using a dermatology questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 2% tofacitinib nail lacquer
- What this could lead to
- If it works, this could offer a new topical option for people with nail psoriasis, potentially improving nail appearance and quality of life without systemic drugs.
- What could go wrong
- This is a very small early-phase trial with only 10 participants, so results may not apply broadly. The treatment may not work or could cause skin irritation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Age ≥ 18 years; * Presence of nail psoriasis in at least one fingernail or toenail; * Patients not using systemic medication, or without adequate response to systemic medication after at least 6 months of use; * Ability to read, understand, and sign the Informed Consent Form (ICF) and the Consent Form for Images, Presentations, and Scientific Publications. Exclusion Criteria: Pregnant or breastfeeding women or those planning to become pregnant during the study period; * History of sensitivity to any components of the study product; * Initiation of systemic medication for nail psoriasis less than six months prior.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.