Hereditary otorhinolaryngologic disease

This trial compares two versions of a surgery called external dacryocystorhinostomy, which creates a new drainage path for a blocked tear duct. Half of the participants receive the standard surgery, while the other half receive the surgery plus a piece of amniotic membrane placed…

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This study tests whether infusing a child's own stored umbilical cord blood stem cells is safe for children with acquired sensorineural hearing loss. The trial enrolls children with moderate to profound hearing loss and aims to see if the infusion can improve inner ear function, …

This study looked at 150 adults with blocked tear ducts who had a surgery called endoscopic DCR. Half received an internal nasal splint during the procedure, and half did not. The goal was to see if the splint helped keep the new tear duct opening clear and reduced scarring. Rese…

This pilot study from France tested two ways to treat otosclerosis, a condition that causes hearing loss. Thirty people first used a hearing aid for at least two months, then had surgery to fix the middle ear bone. Researchers measured quality of life after each treatment to see …

This study tests whether a modified action camera can take clear images inside the nose, compared to the standard large camera system. Forty adults with tearing or sinus issues will have both types of images taken during their routine exam. Doctors will rate the image quality to …

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This study tested whether ultrasound of the nerves can help diagnose CANVAS, a rare genetic disorder that causes balance problems, nerve damage, and dizziness. Researchers measured nerve size in 35 people with confirmed CANVAS and compared them to healthy individuals. The goal wa…

This trial tests whether adding a low-dose propofol infusion during general anesthesia can prevent post-operative nausea and vomiting (PONV) in adults with a history of PONV or motion sickness. Participants receive either a hybrid approach (propofol plus sevoflurane) or propofol …

This study tests two types of exercises to help people who get dizzy, nauseous, or have blurry vision from using computers for long hours. 46 computer users will do either head-movement or eye-movement exercises for 4 weeks. The goal is to see which exercise better reduces sympto…

This trial tests whether communication training helps first-time hearing aid users with mild to moderate hearing loss adapt better. Participants receive training either in a group or one-on-one, and researchers compare their hearing-related quality of life, communication strategi…

This study looked at 73 people with otosclerosis who had stapes surgery using bone cement to fix the middle ear bones. The goal was to see if bone cement helps improve hearing over the long term. Researchers measured both conductive and sensorineural hearing changes with hearing …

This study tests an experimental drug called SPI-1005 (ebselen) in adults with Meniere's disease, a condition that causes vertigo, tinnitus, and hearing loss. The trial compares three doses of SPI-1005 against a placebo to see if it safely reduces these symptoms. Researchers will…

This study tested whether eye and neck exercises can reduce dizziness and uncontrolled eye movements in young adults with benign paroxysmal positional vertigo (BPPV). Fifty-six participants did either eye exercises alone or combined eye and neck exercises for six weeks. The goal …

This study tested a 4-week virtual reality exercise program to help people who get motion sickness from visual cues, like in VR or certain videos. 46 adults, some with and some without motion sickness, took part. The program used 360-degree travel videos in a VR headset to gradua…

This study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…

This study tested different doses of liposomal bupivacaine, a long-lasting numbing medicine, in 55 adults having shoulder surgery. The goal was to find the smallest dose that still blocks pain but lets patients move their arm. Researchers used a special method where each patient'…

This completed study tested whether adding gastrodin acupoint injections to standard care helps people with sudden hearing loss and vertigo. One hundred adults received either standard therapy alone or standard therapy plus injections into specific acupuncture points over four we…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study looks at how taking caffeine in different ways—daily low doses, gradually increasing doses, or only on workout days—affects muscle growth and strength in 180 young men who don't normally drink caffeine or exercise with weights. Participants will follow two 4-week super…

This study investigates whether a quick, painless electrical measurement called transimpedance matrix (TIM) can detect scar tissue (fibrosis) that sometimes forms inside the cochlea after cochlear implant surgery. Researchers will compare TIM results with CT scans in 180 adults w…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This completed study enrolled 186 people with mild to moderate hearing loss to understand how damage to inner ear sensory cells and auditory neurons affects speech understanding, especially in noisy environments. Participants were fitted with hearing aids and tested on speech rec…

This study looked at how two common seasickness drugs (scopolamine and meclizine) change inner ear balance tests in 54 healthy soldiers who get seasick. Researchers measured eye movements before and after taking the drugs to see if these tests could predict which drug works best …

This study tested whether healthy volunteers with minimal training could collect their own blood using a finger prick during brief periods of weightlessness on parabolic flights. The goal was to see if the blood samples were good enough to measure caffeine levels. Thirty particip…