Can a simple anesthesia tweak stop Post-Surgery nausea?
NCT ID NCT05759481
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether adding a low-dose propofol infusion during general anesthesia can prevent post-operative nausea and vomiting (PONV) in adults with a history of PONV or motion sickness. Participants receive either a hybrid approach (propofol plus sevoflurane) or propofol alone for total intravenous anesthesia. The study tracks nausea, retching, or vomiting within 24 hours after surgery to see if the propofol infusion helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A low-dose propofol infusion added to standard anesthesia, or propofol used alone for total intravenous anesthesia.
- What this could lead to
- If effective, this could offer a simple way to reduce post-operative nausea and vomiting in people prone to it, improving recovery comfort.
- What could go wrong
- This is a small phase 2 trial, so results may not be definitive. Propofol can cause side effects like low blood pressure or breathing issues, and the added infusion may not significantly reduce nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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65 people
The number who actually took part.
- Started
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Feb 2024
- Finished
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Mar 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Undergoing general anesthesia for elective surgery 2. Documented history of Patient's self-disclosure of PONV and/or motion sickness during pre-anesthesia discussions 3. No documented allergy/adverse reaction to propofol 4. English speaking 5. At least 18 years of age Exclusion Criteria: 1. Any anti-nausea medication taken within 24 hours prior to surgery 2. Unable to provide consent independently 3. Allergy or adverse reaction to propofol 4. Emergency surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Penn State Health Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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