Generalized anxiety disorder

This trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder (GAD). About 384 participants will receive either the drug or a placebo daily for 8 weeks. The main goal is to see i…

This trial tests whether a non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) can enhance the effects of standard anxiety medication in adults with generalized anxiety disorder. Participants are randomly assigned to receive cTBS targeting on…

This Phase 3 trial evaluates the long-term safety and tolerability of an experimental drug called ITI-1284, taken under the tongue, for people with generalized anxiety disorder (GAD) who have not responded to previous treatments. Participants receive ITI-1284 either alone or alon…

This phase 3 trial is testing whether an experimental oral medication called SEP-363856 (ulotaront) can reduce anxiety symptoms in adults with generalized anxiety disorder. Participants will receive one of two fixed doses of the drug or a placebo for 8 weeks. The main goal is to …

This study tests whether using a person's genetic information to guide medication choices leads to better recovery for people with mood, anxiety, or psychotic disorders. Over 2,500 participants will receive either standard care or personalized medication advice based on their gen…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study compares two care models for treating anxiety in 556 children and teens aged 8-17. In stepped care, everyone starts with internet therapy and gets in-person help only if needed. In stratified care, participants are assigned to internet or in-person therapy based on the…

This study is testing whether a computer-delivered cognitive behavioral therapy (CBT) program can help people who have both an anxiety disorder and alcohol use disorder. The program teaches skills like breathing control and problem solving to break the cycle of negative feelings …

This study aims to create a short, simple questionnaire that doctors can use during routine check-ups to quickly screen childhood cancer survivors for anxiety and depression. About 545 participants aged 6 to 25 who have finished intensive cancer treatment and are in remission wil…

This study is testing a digital app called QbMobile that measures attention, impulsivity, and activity levels through two 10-minute tests. Researchers want to see if the app can help distinguish ADHD from conditions like bipolar disorder, autism, depression, and anxiety. About 30…

Researchers are testing whether an accelerated protocol of transcranial magnetic stimulation using the BTL-699-2 device can reduce anxiety symptoms in adults with generalized anxiety disorder. The trial enrolls 40 adults aged 22 and older who receive 16 stimulation sessions over …

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

Researchers are testing a computer-based program that aims to change how anxious children interpret ambiguous situations as threatening. The trial enrolls 72 youth ages 10 to 17 with generalized, separation, or social anxiety disorder. Participants are randomly assigned to either…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

Researchers in Pakistan are testing whether Solution-Focused Therapy, a short talking therapy that focuses on goals and strengths, can reduce symptoms of generalized anxiety disorder in emerging adults. The study will enroll 50 people with mild to moderate anxiety and randomly as…

This study tests whether a daily tablet called ITI-1284, taken under the tongue, can help people with generalized anxiety disorder whose current treatments aren't working well enough. About 570 adults will receive either the drug or a placebo, and researchers will measure changes…

This study tests an experimental drug called ITI-1284 for people with generalized anxiety disorder (GAD) whose current treatment isn't working well enough. About 705 adults will receive either ITI-1284 or a placebo added to their usual therapy. The goal is to see if the drug safe…

This study explores whether personalizing therapy for anxiety—by matching people to cognitive, behavioral, or mindfulness-based approaches—can improve outcomes. Researchers will look for baseline predictors of success and compare brief video-based skill training to four sessions …

This Phase 2 trial tests whether a single injection of RE104 can reduce anxiety symptoms in 64 adults with generalized anxiety disorder, compared to a placebo. Participants receive one dose and are followed for four weeks to measure changes in anxiety severity using a standard ra…

This study tests whether adding a computer task called gaze-contingent music reward therapy (GCMRT) to standard cognitive behavioral therapy (CBT) helps reduce anxiety in children aged 8 to 17. In GCMRT, children look at faces on a screen while pleasant music plays or stops depen…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This trial investigates whether a low-dose psilocybin oral solution can safely ease symptoms of generalized anxiety disorder (GAD). Adults aged 18-60 with a GAD diagnosis and moderate-to-severe anxiety will first receive open-label psilocybin for four weeks, then those who respon…

This study tests whether a new form of exposure therapy, called Expectancy Focused Exposure (EFE), can reduce anxiety symptoms and prevent fear from returning more effectively than traditional exposure therapy. Adults with anxiety disorders—such as social anxiety, panic disorder,…

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This trial tests whether an 8-week mindful self-compassion training can reduce symptoms of anxiety and depression in adults diagnosed with generalized anxiety disorder, social anxiety disorder, panic disorder, or major depressive disorder. Participants are randomly assigned to th…

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This pilot study is testing a device that sends a mild electrical current to the brain (tACS) to see if it can reduce anxiety and improve sleep in people with generalized anxiety disorder and chronic insomnia. Thirty adults will receive 20 sessions over four weeks. The goal is to…

This study tests a new drug called ABBV-932 for adults with generalized anxiety disorder (GAD) who still have symptoms despite taking antidepressants. About 315 participants will receive either ABBV-932 or a placebo alongside their current antidepressant for 6 weeks. The goal is …

This study tests whether a single dose of the experimental drug SYT-510 can reduce anxiety-related brain activity and behavior in 24 adults with generalized anxiety disorder. Participants will receive either the drug or a placebo, then switch after a washout period. The goal is t…

This study tests whether a friendly robot, personalized to each user, can help college students with anxiety complete their cognitive behavioral therapy (CBT) exercises at home. About 140 students with mild to moderate anxiety will use the robot for 6 weeks. The goal is to see if…

This study tests a type of talk therapy called acceptance and commitment therapy (ACT) for people with mild dementia and their care partners. The goal is to see if it helps reduce depression, anxiety, and grief. About 100 pairs will take part, either in person or online.

This study tests whether group metacognitive therapy works as well as individual therapy for people with generalized anxiety disorder. 64 adults will be randomly assigned to either 10 weekly group sessions or 10 weekly individual sessions. The goal is to see if the group format c…

This study is testing a self-guided internet program called Velibra for people with panic disorder, social anxiety, or generalized anxiety disorder who are on a waitlist for treatment. The program uses cognitive behavioral therapy techniques over six weeks. Researchers want to se…

This study tests whether AI-generated audio stories can help people with anxiety and fear of failure. Forty adults will listen to personalized scenarios based on childhood memories of criticism, with one version including a therapeutic twist where a supportive figure steps in. Th…

This study tests two types of social therapy for young adults (ages 18-30) with eating disorders or anxiety. One group gets educational sessions about brain function and social processing; the other adds interactive art tasks done in teams. Researchers will track changes in eatin…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests if text messages can help people with Generalized Anxiety Disorder worry less. 300 adults with high worry levels will receive either safety-behavior fading tips via text or a relaxation exercise. The goal is to see if the text approach reduces worry and anxiety s…

This study tests whether a 6-week music program—including drumming and rhythm exercises—can reduce stress, anxiety, depression, and chronic pain in adults living in rural residential care facilities. Sixty participants will attend weekly hour-long sessions and complete surveys be…

This study tests whether using a digital medical device (Aurora®) that delivers cognitive behavioral therapy, along with usual anxiety medication, works better than medication alone. About 162 adults with moderate-to-severe generalized anxiety disorder will use the device for 12 …

This study tests whether a newer type of talk therapy called transdiagnostic metacognitive therapy (tMCT) works better than standard cognitive-behavioral therapy (CBT) for people with generalized anxiety, social anxiety, or PTSD. About 86 adults in Sweden will receive either tMCT…

This study is testing a type of talk therapy called Emotion Regulation Therapy (ERT) delivered over video for people in New York who struggle with worry, overthinking, or being hard on themselves. The goal is to see if the therapy helps people better manage their emotions and fee…

This study tests whether combining a gentle brain stimulation technique (tDCS) with cognitive-behavioral therapy (CBT) can reduce repetitive negative thinking in adults with generalized anxiety disorder or depression. About 85 participants will receive either real or sham tDCS du…

This study is testing whether adding a low or moderate dose of FDA-approved cannabidiol (Epidiolex) to cognitive behavioral therapy (CBT) helps adults with generalized anxiety disorder more than CBT plus a placebo. Researchers will measure changes in brain activity related to emo…

This study tests a stepped care model for treating anxiety in children and teens aged 7-17. It starts with a low-cost, parent-focused therapy and offers more intensive treatment only if needed. The goal is to make effective care more accessible while reducing costs and therapist …

This study is developing and testing a new internet-delivered cognitive behavioral therapy (ICBT) program for children and teens aged 8-17 with anxiety disorders. The 12-week program, guided by a therapist, uses exposure therapy to help young people face their fears. Researchers …

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study is testing two different ways of delivering intensive cognitive behavioral therapy (CBT) to veterans with PTSD and anxiety disorders. One format is individual therapy over two weeks, and the other is group therapy over two days. Both are compared to standard care. The …

This study is testing an 8-week group program that teaches meditation, breathing, and relaxation skills to help medical graduate students manage mood symptoms like anxiety and depression. About 60 students with mild-to-moderate symptoms will participate. The goal is to see if the…

This study tests a new medication called crisugabalin for people with generalized anxiety disorder. About 216 Chinese adults will receive either crisugabalin, a placebo, or an existing drug (venlafaxine) for 8 weeks. The goal is to see if crisugabalin reduces anxiety symptoms bet…

This study looks at whether combining two common therapy techniques—changing negative thoughts and practicing detached mindfulness—works better than using them alone for people with anxiety or depression. Researchers will compare the effects of each technique and their order. The…

This study tests whether a parent-only therapy (SPACE) can reduce anxiety in teens, compared to a parent education support group. About 108 adolescents with anxiety disorders will participate. Parents attend 12 weekly sessions, and researchers measure teen anxiety symptoms before…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study looks at whether giving people with generalized anxiety disorder the power to choose between two internet-based treatments helps them feel better and stick with the program. About 440 adults will either pick their preferred therapy or be assigned one randomly. The goal…

This pilot study tests whether artificial intelligence can create personalized therapy scripts to help adults reframe painful memories of childhood criticism. Eighty participants with anxiety will listen to AI-generated audio scenarios based on their own memories. Half will recei…

This study looks at a telephone-based program called SUSTAIN that helps older adults (65+) manage depression, anxiety, and chronic pain. Participants receive brief phone assessments and care management over 12 weeks. Researchers want to see what factors influence treatment succes…

This study tests whether a non-invasive brain stimulation method called continuous theta burst stimulation (cTBS) can reduce anxiety in people with generalized anxiety disorder (GAD). Forty participants will be randomly assigned to receive either real or sham (placebo) stimulatio…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study aims to understand the brain mechanisms behind fear and anxiety in people with anxiety disorders like PTSD and GAD. Researchers will measure brain activity, heart rate, and skin responses while participants view fear-provoking images or use virtual reality. The study i…

This study looks at whether a single session of a brain stimulation technique called rTMS can change heart activity in women who have had multiple pregnancy losses and also have anxiety. Forty-six women will receive either real or fake stimulation while their heart rate is monito…

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously completed a trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to learn what participants thought about each treatment to h…

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study looks at how exercise training impacts blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers want to understand if harmful substances called oxidants play a role in blood vessel damage. The study involve…

This study is testing whether a carbon dioxide (CO2) challenge can predict which patients with anxiety, OCD, PTSD, or panic disorder will not respond to exposure-based therapy. Researchers will enroll 600 adults and measure their reaction to breathing CO2-enriched air before star…

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study is looking at how environmental factors in cities—like air pollution, noise, and lack of green space—affect people with depression, anxiety, or alcohol use disorder. Researchers will have 680 participants wear smartwatches to track heart rate, activity, and other body …

This study checks how well a new version of a mental health interview (CIDI 5.0) can identify people who have had depression, anxiety, or PTSD at some point in their lives. Researchers in Hong Kong will interview 300 adults and compare the results with a detailed clinical assessm…

This study is a large survey of up to 20,000 adults with conditions like depression, anxiety, or borderline personality disorder. Researchers will ask about medical history and symptoms to see who might qualify for future industry-sponsored clinical trials. The goal is to make it…

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study aims to understand why some people get stuck in repetitive negative thinking, common in depression and anxiety. Researchers will compare brain activity in 50 patients and 50 healthy volunteers using a harmless brain-imaging device during emotion tasks. The goal is to u…

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder, compared to healthy individuals. Researchers will measure changes in arm and leg blood vessel dilation after 10 weeks of strength training. The go…

This study looks at how exercise affects brain markers linked to anxiety. Thirty adults with anxiety disorders will follow a 4-week virtual exercise program. Researchers will measure specific brain chemicals from blood samples to understand the biological changes behind exercise'…

This study tests whether a device called rTMS, which uses magnetic pulses to temporarily change brain activity, can alter how people with anxiety respond to fearful situations. Researchers will measure brain signals and reactions in 80 adults who recently started anxiety treatmen…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…

This study follows up to 10,000 medical students in Orléans, France, for up to 22 years to understand what puts them at risk for depression and other mental health issues. Participants fill out an annual online questionnaire. The goal is to identify early warning signs so that fu…

This study looks at how stress and anxiety affect learning and decision-making. Researchers will have participants do tasks like putting a hand in ice water or warm water, then measure how they value rewards and predict emotions. The goal is to understand the link between stress,…

This study looks at whether a person's mental state—like anxiety or depression—can influence how well immunotherapy works for triple-negative breast cancer. About 120 women will receive standard treatment, complete psychological surveys, and give blood and saliva samples. Researc…

This study looks at how different exercise programs affect blood vessel function in people with PTSD or generalized anxiety disorder. Researchers will compare moderate versus high intensity exercise in 360 participants. The goal is to see if exercise can improve vascular health, …

This study tests whether a technology called transcranial focused ultrasound (tFUS) can temporarily change brain activity linked to anxiety. Researchers will recruit 40 adults with anxiety disorders who recently started treatment. Participants will undergo brain imaging and then …