Coronary atherosclerosis

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests a new device called ShockFast IVL against an existing one, ShockWave IVL, for treating hardened calcium deposits in heart arteries. Both devices use sound waves to break up calcium so a stent can be placed more easily. The trial will involve 120 adults with coron…

This study looks at how a special balloon called the OPN balloon is used to open severely hardened or blocked heart arteries. Researchers will track 300 adults who need this procedure to see how well it works and what problems might happen. The goal is to learn the best ways to u…

This study tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if the device is safe and effective at clearing blockages to im…

This study tests whether combining aerobic exercise with strength training helps people recover better after coronary artery bypass graft (CABG) surgery. Participants, aged 30 to 60 and cleared for phase II cardiac rehab, are randomly assigned to aerobic exercise alone or aerobic…

This study compares two techniques for treating severely hardened heart arteries: using a special drill (rotational atherectomy) plus shockwave therapy versus shockwave therapy alone. About 120 adults with coronary artery disease will be randomly assigned to one of the two approa…

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed for people with long blockages in their heart arteries. The goal is to see if the stent is safe and works well at keeping arteries open for up to 12 months. About 100 pa…

This pilot study tests whether the drug colchicine can reduce artery plaque in 120 heart attack survivors who have a specific genetic change (TET2-CHIP). Participants take colchicine or standard care for 12 months. The goal is to see if this genetic marker can guide personalized …

This study compares two medical devices used to break up hard calcium deposits in heart arteries before placing a stent. It involves 50 adults with coronary artery disease who will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy. The goal i…

This study looks at 110 women with blocked heart arteries who need bypass surgery. It compares using the arm artery versus a leg vein (prepared with a special no-touch method) to reroute blood flow. The goal is to see which graft stays open longer and leads to fewer heart problem…

This study tests a new device that freezes dangerous plaque in heart arteries to see if it can reduce blockages and prevent future heart problems. About 30 people with stable angina or recent heart events will receive the freezing treatment during a planned procedure. Researchers…

This study tests if using a single device (orbital atherectomy) to sand away calcium in heart arteries works as well as letting doctors choose from several methods based on each patient's calcium type. About 310 adults with severely calcified arteries will be randomly assigned to…

This study tests whether ziltivekimab, a monthly injection that reduces inflammation, can improve artery health in people who have recently had a heart attack. About 332 participants will receive either the drug or a placebo, alongside standard care. Researchers will use special …

This study tests two ways to break up heavy calcium buildup in heart arteries before placing a stent: a super high-pressure balloon versus a special shockwave balloon (lithotripsy). About 78 adults with severe coronary artery disease will be randomly assigned to one method. The g…

This study tests whether a drug-coated balloon works as well as a drug-eluting stent for people with severe calcium deposits in their heart arteries. After using special tools to break up the calcium, 656 participants will be randomly assigned to one of the two treatments. Resear…

This study tests a new medicine called YN001 in people with coronary atherosclerosis (hardening of the arteries in the heart). The goal is to see if YN001 can reduce plaque buildup in the arteries when added to standard care. About 24 adults in Australia with at least one blocked…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special …

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

This study tests whether rapidly adjusting cholesterol-lowering medications, based on frequent blood tests, helps heart disease patients reach their LDL cholesterol targets faster. Researchers will enroll 1000 adults with coronary artery disease and monitor their cholesterol leve…

This study is testing whether taking clopidogrel (a blood thinner) every day for at least 5 years can prevent heart attacks, strokes, and death in people who have early signs of coronary artery disease on scans but no symptoms. About 11,000 adults aged 40 and older will be assign…

This study tests a new device called the SoniCracker IVL, which uses tiny shockwaves to break up hard calcium deposits in heart arteries. The goal is to make it easier to place stents and improve blood flow. About 40 adults with calcified coronary arteries will be enrolled. Resea…

This study compares two approaches to stabilize fatty plaque in heart arteries: a moderate-dose statin plus ezetimibe versus a high-dose statin alone. Over 400 adults with coronary artery disease will be followed for a year, using advanced ultrasound to measure plaque changes. Th…

This study is testing a new MRI technique called CATCH to improve how doctors evaluate coronary atherosclerosis—the buildup of plaque in heart arteries. The goal is to make the scan faster, simpler, and more reliable than current methods, especially for identifying 'hot spots'—pl…

This study compares two types of CT scans—PET/CT and ultra-high-resolution CT—to see which one better detects early signs of coronary artery disease in people with symptoms like chest pain. Researchers will measure the amount of plaque in the arteries and check how accurately eac…

This study tests a new MRI technique that uses a special iron-based contrast agent (ferumoxytol) to detect calcium buildup in heart arteries. Researchers will compare this method to standard CT scans in 100 adults with known calcified arteries. The goal is to see if the MRI can a…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of people with mild heart disease. Researchers will use advanced CT scans to measure changes in plaque size and type over 3 months, and then check if those changes las…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study is tracking 500 patients who received rotational atherectomy, a procedure that uses a tiny rotating burr to grind away hardened plaque in heart arteries. Researchers want to see how safe and effective it is in real-world settings. The main goal is to measure how many p…

This study looks at a fast-progressing type of coronary artery disease that may be driven by inflammation. Researchers will compare 20 patients with this condition to 10 patients with typical heart disease, using lab tests, imaging, and physical assessments. The goal is to better…

This study looks at why people with angina but no blocked arteries (ANOCA) often have poor fitness. Researchers will test whether a 4-week, remotely supervised high-intensity interval training (HIIT) program can safely improve heart function, exercise capacity, and quality of lif…