Complex regional pain syndrome

This trial tests whether a new type of deep brain stimulation (DBS) can better relieve chronic pain that hasn't responded to other treatments. Unlike traditional DBS, which delivers constant stimulation, this approach uses a device that adapts stimulation in real time based on br…

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study wil…

This phase 3 trial tests whether the drug neridronate, given as four IV infusions over 10 days, can reduce pain and other symptoms of complex regional pain syndrome type 1 (CRPS-1). About 270 adults with CRPS in one limb will receive either the drug or a placebo. The main goal is…

This trial tests whether extracorporeal shock wave therapy (ESWT), which delivers sound waves to painful areas, can ease symptoms of complex regional pain syndrome type I (CRPS-I) that sometimes follows a wrist fracture. Sixty adults with CRPS-I will receive standard rehabilitati…

This trial tests whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can reduce pain avoidance behavior in people with Complex Regional Pain Syndrome (CRPS). Participants receive either real tACS at a frequency linked to p…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with severe Complex Regional Pain Syndrome (CRPS). Researchers will measure pain levels, wrist movement, and daily function in 60 adults with CRPS. The goal is to s…

This study tests whether a device that combines hot and cold therapy with gentle compression can reduce pain, swelling, and improve hand function in people with Complex Regional Pain Syndrome (CRPS) after a hand or wrist injury. Half of the participants will use this combined the…

This study tests whether transcranial magnetic stimulation (TMS) can reduce pain and improve thinking, mood, and physical function in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either real TMS or a sham treatment for two days. Researche…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or le…

This study tests whether task-based mirror therapy can reduce pain, swelling, and improve arm function in stroke survivors who develop shoulder-hand syndrome. Thirty-four participants aged 45-75 will be split into two groups: one doing mirror therapy plus standard exercises, the …

This study looks at whether using a nerve stimulator in short bursts (30 seconds on, 90 seconds off) can provide the same or better pain relief as continuous stimulation. It involves 30 adults who have had a dorsal root ganglion stimulator for at least a year and report at least …

This study tests whether using a closed-loop spinal cord stimulator early in complex regional pain syndrome (CRPS) works better than waiting until the chronic phase. The device automatically adjusts its settings based on the body's signals. Researchers will enroll 32 adults with …

This study tests whether wearing compression garments (gloves or sleeves) can reduce nerve pain in people with Complex Regional Pain Syndrome (CRPS) of the upper limbs. Sixty participants will either receive usual care plus the garment or usual care alone for three months. Pain l…

This study tests whether combining brain stimulation (rTMS), personalized physical therapy, and medication adjustments can reduce pain and improve daily function in people with Complex Regional Pain Syndrome (CRPS). Researchers will enroll 156 adults whose symptoms began within t…

This study tests a new program called PREP-Y, designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly virtual sessions teaching resilience skills like motivation and cop…

This study tests whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can reduce pain and improve arm function in stroke patients who develop complex regional pain syndrome. About 32 adults will receive the injection plus standard physical therap…

This study looks at whether certain biological signs—like genetic markers, blood chemicals, and heart rate patterns—can predict who will recover well from a wrist fracture and who might develop chronic pain or a condition called Complex Regional Pain Syndrome. Researchers will al…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study uses virtual reality to explore how people with upper limb exclusion (non-use of an arm or hand) perceive the space around them. Researchers will compare 60 participants—those with the condition and healthy controls—as they judge whether virtual objects are reachable. …

This study uses a special thermal camera to take pictures of the feet of people with complex regional pain syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the stimulation changes blood flow and temperature in the painful limb. Research…

This study looks at whether the bacteria in your gut are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare gut microbiome samples from people with CRPS and their household members. They also aim to pre…

This study looks at how spinal cord stimulation (SCS) changes certain molecules in the blood and spinal fluid of people with long-term nerve pain. Researchers will measure inflammatory markers and other signaling molecules before and after SCS in 30 adults. The goal is to underst…