Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a common steroid stop wrist fracture pain from becoming chronic?

NCT ID NCT06453447

Disease control Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study will enroll 40 adults at risk of CRPS, randomly giving them either prednisone or a placebo for two weeks, and track outcomes like pain resolution and opioid consumption.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Prednisone
What this could lead to
If it works, this could point toward a simple, short-term treatment to prevent chronic pain and disability after wrist fractures.
What could go wrong
This is a very small pilot study (40 people) focused on feasibility, not proof of effectiveness. Prednisone has side effects like weight gain and mood changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patient is aged 19 years or older; 2. Patient has a unilateral, closed, distal radius fracture confirmed by radiographs; 3. The fracture is acute, within 21 days of injury; 4. Patient undergoes open reduction internal fixation with volar locking plate; 5. Patient is identified as at risk of developing CRPS with 2 or more of the following: 1. Pain score on visual analogue scale (VAS) greater than or equal to 5/10 within 1 week of injury and beyond; 2. Centre of Epidemiologic Studies Depression (CES-D) score on presentation is greater than or equal to 16; 3. Patient identifies as female; 6. Patient is identified as developing signs of CRPS based on the Budapest CRPS Criteria; 7. Patient provides informed consent. Exclusion Criteria: 1. Patient has previously fractured ipsilateral wrist; 2. Patient has neurovascular injury associated with distal radius fracture; 3. Patient has associated extremity or polytrauma injuries that would interfere with rehabilitation and outcome measurements, in the opinion of the investigator; 4. Patient has allergy to prednisone or placebo ingredients; 5. Patient has contraindication to prednisone or placebo ingredients; 6. Patient already takes a glucocorticoid medication; 7. Patient has active bacterial, viral, or fungal infection; 8. Patient is diagnosed with diabetes; 9. Patient is pregnant, planning on becoming pregnant, or breastfeeding; 10. Patient is anticipated to have difficulty completing study follow up, in the opinion of the investigator.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Complex regional pain syndromes are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

complex regional pain syndrome Pain radius fracture Wrist Fractures

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complex regional pain syndromes Distal radius fractures

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vancouver General Hospital

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.