New hope for CRPS sufferers: brain zaps and therapy combo put to the test
NCT ID NCT07208825
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining brain stimulation (rTMS), personalized physical therapy, and medication adjustments can reduce pain and improve daily function in people with Complex Regional Pain Syndrome (CRPS). Researchers will enroll 156 adults whose symptoms began within the last 5 years. All participants will receive rTMS and basic rehabilitation, but the timing and addition of specialized neurological therapy will vary between groups. The goal is to find a better way to manage this often-debilitating condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS), physical therapy, functional neurology, and medication optimization
- What this could lead to
- If successful, this could point toward a more effective, non-drug rehabilitation plan that helps CRPS patients better manage pain and return to work.
- What could go wrong
- This is an early-phase study with no placebo group, so results may not prove which part of the treatment works. CRPS is notoriously hard to treat, and full recovery is rare.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 156 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2033
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * CRPS symptoms maximum of 5 year at the time of diagnosis (CRPS 1 and 2) * 18 to 70-year-old * rTMS treatment is granted by university hospital pain clinic (by multidisciplinary group) * Voluntary to participate into the study Exclusion Criteria: * CRPS symptoms started over five years ago (although diagnosed first time now) * No other outpatient/inpatient rehabilitation during the study rehabilitation period (insurance company or other third party) * Under 18-years-old of over 70-years-old * No eligible to rTMS treatment or for other reason rTMS treatment was not granted by university hospital pain clinic (by multidisciplinary group)
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Oulu University Hospital, Pain Clinic
RECRUITINGOulu, North Ostrobothnia, 90100, Finland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Zapping the brain to fight teen pain: a new hope?
- Could Botox-Like shots ease debilitating CRPS pain?
- Can special goggles reduce CRPS pain? new study tests prism therapy
- Could turning nerve stimulation on and off beat continuous therapy for chronic pain?
- Heat-Sensing camera could gauge CRPS pain severity