New hope for CRPS sufferers: brain zaps and therapy combo put to the test
NCT ID NCT07208825
First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 33 times
Summary
This study tests whether combining brain stimulation (rTMS), personalized physical therapy, and medication adjustments can reduce pain and improve daily function in people with Complex Regional Pain Syndrome (CRPS). Researchers will enroll 156 adults whose symptoms began within the last 5 years. All participants will receive rTMS and basic rehabilitation, but the timing and addition of specialized neurological therapy will vary between groups. The goal is to find a better way to manage this often-debilitating condition.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Oulu University Hospital, Pain Clinic
RECRUITINGOulu, North Ostrobothnia, 90100, Finland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive transcranial magnetic stimulation (rTMS), physical therapy, functional neurology, and medication optimization
What this could lead to
If successful, this could point toward a more effective, non-drug rehabilitation plan that helps CRPS patients better manage pain and return to work.
What could go wrong
This is an early-phase study with no placebo group, so results may not prove which part of the treatment works. CRPS is notoriously hard to treat, and full recovery is rare.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.