Chronic periodontitis

This trial tests whether adding injectable platelet-rich fibrin (i-PRF) to a minimally invasive non-surgical gum treatment helps heal grade II furcation defects—areas where bone loss has occurred between tooth roots. Adults with stage III, grade B periodontitis and such defects w…

This study is testing a gel that turns into a gel when warmed, used alongside standard gum disease treatment. It includes 70 adults, some with type 2 diabetes and some without, to see if the gel helps gums heal better and if healing differs between the two groups. Participants wi…

This study tests whether an electrolysed saline mouth rinse can improve standard gum disease treatment. Sixty adults with advanced periodontitis will use either the saline rinse, a standard antiseptic rinse, or a placebo for one month. The goal is to see if the rinse reduces deep…

This study compares two ways to treat gum disease without surgery: using an ultrasonic device or special hand tools. About 36 adults with moderate to severe periodontitis will be randomly assigned to one method. Researchers will check gum pocket depth and bone levels over a year …

This study tests whether a gel made from a patient's own blood can improve gum healing after standard deep cleaning for moderate to severe gum disease. About 14 adults with gum pockets of 5mm or deeper will receive the blood gel on one side of the mouth and a saltwater rinse on t…

This study tests whether a gel made from enamel proteins can thicken gum tissue around dental implants. Researchers will measure gum thickness in 32 adults who need implant uncovering surgery. The goal is to see if this treatment improves gum health and implant stability.

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to s…

This study tests a non-surgical treatment for deep gum pockets (furcation defects) in people with advanced periodontitis. One side of the mouth gets a chitosan brush plus enamel matrix derivative; the other side gets the brush alone. The goal is to see if the added gel improves g…

This study explores whether a simple finger-prick blood sugar test done during a routine dental visit can help find people with advanced gum disease who have undetected high blood sugar. Adults with severe periodontitis but no known diabetes will be tested at the dental clinic an…

This study compares two types of ultrasonic devices used to clean deep gum pockets in people with early-stage periodontitis. Researchers want to see which device causes less pain, noise, and vibration during treatment, and how well each helps gums heal. Fifty-two adults will be r…

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study looks at whether deep dental cleaning (subgingival instrumentation) can reduce 'allostatic load' — the wear and tear stress puts on the body. Researchers will treat 112 adults aged 30-50 with gum disease and measure inflammation, blood sugar, and cholesterol levels bef…

This study is checking how often the fungus Candida albicans shows up in the gums of 100 Syrian adults with periodontitis (serious gum disease). Researchers will collect plaque samples and measure gum health to see if the fungus is linked to more severe disease. The goal is to be…

This observational study looks at gum tissue from people with aggressive or chronic periodontitis and healthy gums. Researchers use advanced genetic tools to map cell types and signals that make aggressive disease different. Only small tissue and blood samples are taken during pl…

This study looks at whether taking probiotics (with or without vitamin B12) can improve the health of the mouth's bacteria and reduce gum disease in adults with severe periodontitis. Participants will receive standard gum treatment plus either a probiotic lozenge, a probiotic wit…

This study looks at a protein called Mitofusin-1 in saliva to see if it can help measure how severe gum disease is and how well treatment works. Researchers will compare healthy people, those with mild to severe gum disease, and smokers with severe gum disease. Participants give …

This study examines how B cells, a type of immune cell, behave in the blood and gums of people with periodontitis (gum disease). Researchers want to see if certain B cell patterns are linked to more aggressive disease and how they change after surgery. The goal is to improve diag…