Adult acute respiratory distress syndrome

This study tests an experimental drug called centhaquine in 80 adults with moderate to severe ARDS, a life-threatening lung condition. The drug is added to standard care to see if it improves oxygen levels and reduces deaths. Participants must be in the ICU and start treatment wi…

This trial tests how different levels of spontaneous breathing during a ventilation mode called APRV affect lung function in adults with moderate-to-severe acute respiratory distress syndrome (ARDS). Each participant receives three breathing conditions in random order: low, high,…

This phase III trial asks whether giving dexamethasone early to adults with severe influenza pneumonia and low blood oxygen can improve outcomes. Participants in intensive or intermediate care receive either the steroid or a placebo for up to 10 days, alongside standard flu treat…

This trial tests whether using electrical impedance tomography (EIT) to guide ventilator pressure settings improves lung function in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) who are placed face down (prone positioning). Researchers will compare …

This study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…

This trial tests whether an AI system can help doctors choose better ventilator settings for children (ages 1 month to 18 years) in the pediatric ICU who need a breathing machine. Half of the children will receive standard care, while the other half will have their ventilator adj…

This early-stage trial tests R-3750, a live biotherapeutic product, in 20 adults with late-stage acute respiratory distress syndrome (ARDS). The main goal is to see if it is safe and tolerable, while also checking for signs of improved lung function and less need for a ventilator…

This study tests whether a traditional Chinese herbal formula, Xuanbai Shengmai Decoction, can improve survival in adults with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in the ICU. About 308 participants will receive either the herbal decoctio…

This study tests a new way to use breathing machines for people with severe lung failure (ARDS). The goal is to reduce lung damage by using very gentle breaths and adding a machine that helps remove carbon dioxide from the blood. About 290 adults on breathing machines for less th…

This study tests a new treatment called JadiCell, made from stem cells from donated umbilical cords, for people with severe lung failure (ARDS). The goal is to see if a single IV dose can calm inflammation and help the lungs heal, so patients need less breathing support. About 12…

This study tests whether giving the steroid betamethasone to extremely premature babies (born before 28 weeks) helps them come off breathing machines more easily and lowers their risk of chronic lung disease. About 100 babies will receive either standard NICU care plus betamethas…

This study tests whether the drug fostamatinib can safely help adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung injury. About 40 participants will receive either the drug or a placebo, and researchers will track serious side effects for 30 days. …

This study compares two types of high-frequency ventilators for premature babies born before 32 weeks who have breathing problems. The new mode, HFOV-VG, aims to deliver more stable breaths to reduce lung injury. Researchers will see if it lowers the chance of severe chronic lung…

This study looks at whether lying on the side at different angles can improve lung function in people with acute respiratory distress syndrome (ARDS), a serious lung condition. About 140 adult patients will be randomly placed in either the standard face-down position or a side-ly…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests whether a combination of three inhaled drugs (furosemide, heparin, and hypertonic saline) can reduce lung injury in adults with acute respiratory distress syndrome (ARDS) who are on mechanical ventilators. The trial will involve 344 participants and measure daily…

Researchers at Assiut University are testing whether lung ultrasound can diagnose pneumonia in newborns as reliably as the standard chest X-ray. The study will enroll 100 infants in the neonatal intensive care unit who have a clinical diagnosis of pneumonia within their first 28 …

This study looks at whether adding a type of stretching called proprioceptive neuromuscular facilitation (PNF) to standard breathing exercises helps patients get off a breathing machine faster. About 93 adults in the ICU who are stable and awake will be split into three groups: o…

This study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…

This study looks at whether three blood markers—sRAGE, CC16, and Syndecan-1—measured soon after a severe chest injury can predict who will develop acute respiratory distress syndrome (ARDS), a serious lung condition, and who might die in the hospital. Adults aged 18 to 60 with se…

This study compares different bedside methods for choosing the optimal ventilator pressure (PEEP) in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). The goal is to see if these methods give similar results and which one best balances keeping lungs ope…

This study looks at whether the force of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can damage the brain. Researchers will measure a protein called S100B in the blood, which is a sign of brain injury, and track thinking and memory problems …

This study looks at two bedside methods to measure how much of the lung can be reopened in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. It also compares four different ways to set the ventilator's positive end-expiratory pressure (PEEP). The g…

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

Hispanic patients are twice as likely to die from respiratory failure as non-Hispanic patients, partly due to deeper sedation and less physical therapy. This pilot study will test a 'safer sedation bundle'—a set of tools and practices to help ICU staff follow guidelines more clos…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study will compare two non-invasive breathing support methods—a face mask that pushes air in and a special nasal tube that delivers high-flow oxygen—for adults in the emergency room with dangerously low blood oxygen. About 500 participants will be randomly assigned to one me…

This study will observe 40 adults with acute respiratory distress syndrome (ARDS) on ventilators. Researchers will adjust the ventilator's pressure settings and use ultrasound to measure vein congestion, checking if certain settings are linked to better kidney outcomes. The goal …

This pilot study will enroll 80 ICU patients with acute hypoxemic respiratory failure to compare two ventilator strategies: one that allows patients to breathe spontaneously and one that fully controls their breathing. The goal is to see if a larger trial is possible and to gathe…

This study looks at how different levels of breathing support (PEEP) affect blood flow congestion in the veins of patients with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidney, and portal veins as absent, modera…

This study looks at how different levels of ventilator pressure affect the heart and lungs in 20 patients with moderate-to-severe ARDS. Researchers will test three pressure settings to see which one best balances lung collapse and overstretching while keeping the heart pumping we…

This study looks at whether using a special imaging technique called Electrical Impedance Tomography (EIT) can help doctors perform safer lung recruitment maneuvers in children with acute respiratory distress syndrome (ARDS). The researchers will enroll 8 children on ventilators …

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study will test a new, non-invasive method called EIT Pulse Wave to measure blood flow to the lungs and predict heart stroke volume in critically ill patients. Researchers will compare it to the standard Swan-Ganz catheter, which is invasive. The study involves 19 adults in …

This observational study will analyze blood and sputum samples from 411 adults with acute respiratory distress syndrome (ARDS) who are on ventilators. Researchers will look for patterns in microbes, metabolites, and gene activity to see if they can predict how well patients respo…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This study will observe 184 adults with acute respiratory distress syndrome (ARDS) who are on a breathing machine. Researchers want to see how different machine settings affect lung injury and survival. The goal is to find safer ways to use ventilators for these critically ill pa…

This study will follow 800 adults with acute respiratory distress syndrome (ARDS) in a Korean hospital to learn about their symptoms, treatments, and outcomes. Researchers will collect data from medical records and monitor how different ventilator settings affect recovery. The go…

This study looks for proteins in the blood that could signal transfusion-related acute lung injury (TRALI), a rare but dangerous complication in ICU patients. Researchers will compare blood samples from 210 people, including ICU patients with and without lung injury, and healthy …

This study will look at 70 children aged 1 month to 18 years who come to the emergency room with severe breathing problems. Researchers at Assiut University Children Hospital want to find out how common these cases are, what causes them, and which children are most at risk. The g…