Acute myocardial infarction

This study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…

This trial tests whether a cardiac rehabilitation program based on a socio-ecological model can improve recovery in adults who have had a first heart attack and undergone a stent procedure. The program goes beyond standard care by providing guidance on exercise, diet, medication,…

This phase 2 trial tests whether a single injection of selatogrel can rapidly prevent platelets from clumping together in adults having a heart attack. Participants receive either an 8 mg or 16 mg dose in the thigh, and researchers measure how quickly platelet activity drops. The…

This study tests whether an interactive avatar-based game on a tablet can help people who have had a heart attack learn how to manage their health after leaving the hospital. Participants are randomly assigned to either standard face-to-face discharge education or the tablet game…

This study tested whether a drug called dexrazoxane, given through a vein, can reduce permanent heart muscle damage in people having a severe heart attack (STEMI). Fifty adults received either the drug or a placebo during their standard stent procedure. The goal was to see if the…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study looked at whether using only ticagrelor (a blood thinner) after heart attack stenting is safe, instead of the usual two-drug combination. It included 200 adults who had a stent placed during a heart attack. The main goal was to check for serious heart problems or stent…

This study tested a new treatment for people who had a severe heart attack and still have weak heart pumping. Doctors took the patients' own blood stem cells, grew more of them in a special machine, and injected them into the heart. The goal was to see if this could improve heart…

This study tested a single intravenous infusion of stem cells (PROCHYMAL) in 220 adults who had their first heart attack within the prior week. The goal was to see if the treatment could safely improve heart function, as measured by MRI scans at 3 months. Participants were random…

This study tested whether injecting a patient's own bone marrow stem cells into the heart's arteries could improve heart function after a heart attack. 90 adults with reduced heart pumping ability were randomly assigned to receive either stem cells plus standard care or standard …

This study tested two types of exercise training—high-intensity interval training (HIIT) and moderate continuous training (MICT)—against standard physical activity advice in 188 people who had a heart attack. The goal was to see which approach best improves fitness and reduces he…

This completed study looked at whether evolocumab, a cholesterol-lowering injection, can reduce major heart problems in people who had a heart attack and have several blocked arteries. Researchers analyzed data from 1862 patients to see if the drug lowers the risk of cardiac deat…

This study tested whether a smartphone app and regular phone calls could help people with heart or lung disease complete rehabilitation at home instead of going to a clinic. The program included exercise tracking, education, and counseling over 12 weeks. Researchers wanted to see…

This study tested a new medicine called FDY-5301 in 120 people having a severe heart attack (STEMI). Participants received either the drug or a placebo during a procedure to open blocked arteries. The main goal was to see if the drug could reduce dangerous heart rhythm problems a…

This study tested whether the diabetes drug dapagliflozin can reduce inflammation and improve outcomes in people with type 2 diabetes who recently had a heart attack. Researchers gave 143 patients either dapagliflozin or standard care for 6 months. They measured heart complicatio…

This study tested whether adding evolocumab, a drug that lowers bad cholesterol, to standard care helps people who recently had a heart attack. The goal was to see if it reduces cholesterol and inflammation in the heart and blood vessels. 100 adults aged 25 to 90 who had a specif…

This study tested a single injection of FDY 5301 in over 2,300 people who had a severe type of heart attack (anterior STEMI) and were getting emergency artery-opening treatment. The goal was to see if the drug could lower the chance of dying or developing heart failure within a f…

This study looked at whether a high-sensitivity blood test for troponin I can accurately determine the stage of a heart attack. Researchers analyzed data from 312 patients across multiple hospitals. The goal is to provide a faster, simpler way to classify heart attack severity wi…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study tests whether artificial intelligence can read a standard ECG to predict how much heart muscle is damaged after a heart attack. Researchers will compare AI-ECG results with MRI images, the current gold standard, in 461 patients who had a heart attack and underwent a pr…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study tests an artificial intelligence platform called Willem that analyzes electrocardiograms (ECGs) to detect heart attacks. Researchers will compare how fast and accurately the AI spots heart attack patterns versus human doctors. The study involves 500 adults who have had…

This study tested a new blood test called SpinChip hs-cTnI that measures troponin, a protein released during a heart attack. Researchers wanted to see if this test could accurately diagnose heart attacks in 1,551 adults arriving at the emergency room with chest pain or other symp…

This study measured troponin I levels in 1355 healthy adults to determine normal ranges for a new rapid test called SpinChip hs-cTnI. Troponin is a protein released during a heart attack, and having accurate normal values helps doctors diagnose heart attacks more reliably. The te…

This study tested a portable, unshielded magnetocardiography (MCG) device in the emergency department to see if it could reliably detect heart attacks. 124 patients with symptoms of acute coronary syndrome participated. The main goal was to see if the device could collect usable …

This pilot study tested whether a common blood test for troponin, a heart damage marker, can tell if a heart attack involves bleeding in the heart muscle. Researchers measured troponin levels in 227 patients after they had a heart attack and compared those with and without bleedi…

This study tested a new blood test that measures a protein on platelets called FcγRIIa. Researchers wanted to see if higher levels of this protein could predict future heart attacks, strokes, or death in people who had already had a heart attack. About 764 participants were enrol…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study investigates whether different types of sleep apnea—a condition where breathing repeatedly stops during sleep—are linked to future heart problems or death in people who have recently had a heart attack. Researchers will use a home sleep test called polygraphy to measur…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study analyzes data from over 377,000 people who had a heart attack and were prescribed blood thinners (clopidogrel, ticagrelor, or prasugrel) in Germany and the United States between 2011 and 2024. Researchers aim to describe how often each drug is used and how much it cost…

This pilot study looks at how common iron deficiency is in people who have recently had a heart attack. Researchers will test iron levels in up to 70 patients and review their medical records. The goal is to gather early data to plan a larger study on whether treating low iron co…

This study looked at how well two types of stents (small mesh tubes) placed in heart arteries after a heart attack become covered by the body's own cells. 22 people who had a heart attack were randomly assigned to get either a SYNERGY stent or a bioresorbable scaffold. Doctors us…

This completed study looked at 530 heart attack survivors from 25 Spanish hospitals to see if women and men differ in how well they follow prevention advice, like taking medications, eating healthy, exercising, and joining rehab programs. Researchers matched women and men by age …

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study looked at 264 patients who had a heart attack complicated by cardiogenic shock. Researchers examined whether the ratio of red blood cell distribution width to albumin (RAR) in the blood could predict major heart problems like death, another heart attack, or stroke duri…

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This completed study tracked 832 heart attack patients in China who developed new-onset atrial fibrillation during their hospital stay. Researchers used continuous heart monitoring to see how the amount of AFib affected risks like death, another heart attack, or heart failure. Th…

This completed study looked at 250 adults who had a severe type of heart attack (STEMI) treated with a stent. Researchers used portable heart monitors to check how often dangerous heart rhythms occurred in people whose heart attack involved bleeding. The goal was to better unders…

This completed study looked at over 6,000 heart attack patients to see how different antiplatelet medications affect the risk of bleeding inside the heart. Researchers compared outcomes like heart-related events, bleeding complications, and death within 30 days. The goal is to he…

This study looked at how long people who had a heart attack should take two blood-thinning medicines (aspirin plus a second drug). About 5,000 patients were randomly assigned to shorter or longer treatment. The goal was to find the best balance between preventing another heart at…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study looked at 250 people who had a severe type of heart attack involving bleeding into the heart muscle. Researchers tested whether a measurement called the wall strain index ratio, taken from a heart MRI, could identify areas of the heart at risk of tearing (rupture). The…

Researchers have created a prediction score to estimate the chance of a hemorrhagic (bleeding) heart attack in patients before they undergo emergency artery-opening treatment. The study involved 252 adults having their first heart attack and treated with primary PCI. The goal is …

This study looked at how different blood-thinning drugs are used in Italian hospitals for patients having a heart attack. Researchers collected information from over 2,800 patients to see which drug combinations and timing doctors actually use. The goal was to describe current pr…

This study looked at whether a technique called postconditioning, done during angioplasty to reopen blocked heart arteries, can reduce damage to the heart muscle. 44 adults having their first heart attack took part. The researchers used MRI scans to measure the area of blocked sm…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study looked at 407 people with a type of heart attack called NSTEMI to see if getting a heart procedure (coronary angiography) within 24 hours leads to better outcomes. Researchers checked how well following this timing guideline predicted death, another heart attack, strok…

This completed study looked at 1,000 heart attack patients to understand why some have no standard risk factors like smoking, high blood pressure, or diabetes. Researchers compared these 'SMuRF-less' patients to those with risk factors, examining their medical history, lab tests,…

This completed study looked at medical records from over 24,000 people across the United States who had a heart attack. The goal was to find out how often a specific complication called hemorrhagic myocardial infarction (bleeding inside the heart muscle) occurs. Researchers also …