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Can intense exercise heal your heart after a heart attack?

NCT ID NCT04863677

Disease control Sponsor: Guangdong Provincial People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested two types of exercise training—high-intensity interval training (HIIT) and moderate continuous training (MICT)—against standard physical activity advice in 188 people who had a heart attack. The goal was to see which approach best improves fitness and reduces heart scarring. Participants exercised for 12 weeks, and researchers measured changes in oxygen uptake and heart tissue using scans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise training programs (HIIT and MICT)
What this could lead to
If successful, this could show that specific exercise programs improve heart function and reduce scarring after a heart attack.
What could go wrong
This is a completed trial with 188 participants, but results may not apply to all heart attack patients. Exercise carries a small risk of injury or heart strain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

188 people

The number who actually took part.

Started

May 2021

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged 18 -75 years 2. Acute myocardial infarction (AMI) patients between 6 weeks and 3 months and had been underwent revascularization, and New York Heart Association functional classification (NYHA) Class I-III; (AMI confirmed by the World Health Organization definition (presence of symptoms of ischemia and changes in electrocardiogram) or the Third Universal Definition of Myocardial Infarction (elevation of a cardiac biomarker along with presence of either symptoms of myocardial infarction or changes in electrocardiogram)) 3. Willing and able to attend the complete cardiac rehabilitation(CR)program on their own，assigned the Informed consent form. 4. Complete the cardiopulmonary exercise testing (CPET) at enrollment or has the CPET report within 1 month. Exclusion Criteria: 1. High-intensity exercise frequently 2. Currently participating in any other clinical trials 3. Have any other diseases which limit their life to less than a year (e.g. severe valvular disease, recurrent ventricular arrhythmias, NYHA Class IV heart failure, severe aortic incompetence, severe atrial fibrillation, cancers, and end-stage renal or liver disease) 4. Dementia ; disability or sports contraindication 5. Severe acute liver failure 6. Severe acute renal failure 7. Unstable vital signs 8. Site investigators consider that the patient will be unable to complete the study and/or attend for follow-up.

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction allergic disease cor pulmonale myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiopulmonary disease Myocardial infarction Training group, sensitivity

Contacts and locations

Locations

  • Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510000, China

More trials for these conditions

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