Acute coronary syndrome

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This study looks at whether a telehealth system can help people in rural areas get better heart care. It connects local emergency services and clinics with heart experts at a major medical center. About 215 adults with heart symptoms will take part. The goal is to see if this app…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 partic…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study compares taking two blood thinners for just 1 month versus the standard 12 months after getting a heart stent. It involves over 3,700 patients with acute coronary syndrome. The goal is to see if the shorter regimen reduces bleeding risks without increasing heart proble…

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study tests whether an implantable heart monitor with remote follow-up can help doctors decide when to prescribe blood thinners to patients who have had a heart attack and developed new atrial fibrillation. The goal is to reduce bleeding complications compared to the standar…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study looks at how well the GENOSS stent works in real-world patients who have had a heart attack or unstable chest pain (acute coronary syndrome). Researchers are tracking heart-related events like death, heart attacks, and the need for repeat procedures. The study involves…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study tests whether a blood test can help doctors safely lower the dose of strong blood thinners (P2Y12 inhibitors) in people who recently had a heart attack or stent. The goal is to reduce bleeding complications without raising the risk of another heart attack or stroke. Ab…

This study compares two methods of prescribing high-intensity interval training (HIIT) for people in cardiac rehabilitation. Thirty adults with heart conditions will follow a 12-week exercise program to see which prescription approach improves fitness, heart function, and oxygen …

This study looked at whether using a person's genetic information to choose their blood thinner medication after getting a heart stent can reduce the risk of heart attacks, strokes, and death. About 4,000 people with heart disease were given either clopidogrel or ticagrelor based…

This study tests a simple idea: telling heart attack survivors that they will have an important fitness test might encourage them to attend cardiac rehab. The trial includes 200 people who had an acute coronary syndrome. The goal is to see if this nudge increases the number of pa…

This study tests whether using a patient's gender, weight, and kidney function to calculate the starting dose of the blood thinner heparin gets patients to the right level faster than the standard flat rate. About 145 adults with blood clots, atrial fibrillation, or mechanical he…

This study tests a program called BAT-CS that combines smoking cessation counseling with mood management for people who have had a heart attack (acute coronary syndrome). The goal is to help them quit smoking and reduce depression symptoms, which could lower their risk of dying f…

This study looks at whether SGLT-2 inhibitors, a type of diabetes medication, can prevent kidney damage from contrast dye used during heart procedures like angioplasty. Researchers will follow 3,600 adults with acute coronary syndrome who are undergoing invasive treatment. The go…

This study looks at whether using a drug-coated balloon (DCB) on vulnerable plaques in heart arteries can prevent future heart problems. 140 people with acute coronary syndrome and non-threatening plaques were randomly assigned to get either standard medication alone or medicatio…

This study compares two blood thinners (ticagrelor plus aspirin) against aspirin alone after coronary artery bypass grafting (CABG) in people who recently had a heart attack or unstable angina. Over 2,200 participants are being followed for 12 months to see if the dual therapy re…

This study tests whether a compact 3-lead ECG device can accurately detect acute coronary syndrome (heart attack) in adults arriving at the emergency department with chest pain. Participants receive a HeartBeam ECG recording within 10 minutes of the standard 12-lead ECG. The goal…

This study tests a new rapid blood test that can detect heart damage in about an hour, right in emergency primary care clinics. Researchers will enroll 2,500 adults with chest pain across six Norwegian clinics to see if the test safely rules out heart attacks and reduces hospital…

This study tests a device called Infrasensor that may help doctors quickly identify people with severe heart artery blockages. About 350 adults with chest pain will use the device for 5 minutes, and results will be compared to standard heart catheterization. If accurate, it could…

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This study is testing whether a special heart scan (dynamic SPECT) can accurately detect remaining blockages in heart arteries after a heart attack, compared to the current standard invasive procedure (FFR). Sixty adults with multiple blocked arteries will receive both tests one …

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study is testing whether a device called magnetocardiography (MCG) can quickly and accurately tell if chest pain is caused by a heart attack. Researchers at Mayo Clinic will use the MCG scanner on 1,000 emergency room patients with chest pain and compare its accuracy to stan…

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart artery procedures helps doctors make better decisions and get better results. About 3,200 people with various heart conditions will be included. The goal is to see if OCT gui…

This study tests a new way to classify heart attacks based on whether a coronary artery is fully blocked (occlusion) or not, instead of the traditional ST-elevation vs non-ST-elevation method. Researchers will compare outcomes in 6,000 patients to see if the new approach leads to…

This trial tests whether a structured prevention bundle can reduce delirium in adults aged 70 and older admitted to a cardiac intensive care unit (CICU). Participants are randomly assigned to either usual care or the bundle, which includes daily pain checks, avoiding sedatives wh…

This study is looking at people hospitalized for a heart attack (STEMI or NSTEMI) who undergo a procedure to open blocked heart arteries, called percutaneous coronary intervention (PCI) or angioplasty. It compares two groups: those having a standard (non-complex) PCI and those ha…

This observational study will enroll about 8,000 adults across Europe who have coronary heart disease or are at high risk for it, including those with diabetes or chronic kidney disease. Researchers will check whether doctors are following European guidelines for lifestyle advice…

This study looks at whether a quick, point-of-care blood test for heart damage can give results faster than standard lab tests for people with chest pain in the emergency room. Researchers will compare the time it takes to get test results and how long patients stay in the ER. Th…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This international registry is collecting information from 2000 people who have had spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks. Researchers will track participants' health over time to better understand the condition and develop best practices fo…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study looks at 40 people who recently had a heart attack and had one blockage treated. Researchers will use special pressure wires and optical imaging to examine other blockages that were not treated. The goal is to see how many of these leftover blockages are actually dange…

This study tracks how doctors in Spain use injectable blood thinners (cangrelor or GPIs) during heart procedures like stent placement. It includes 717 patients and will look at short-term outcomes like death, heart attack, stroke, and bleeding within 48 hours. The goal is to unde…

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…