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Global SCAD registry launches to prevent recurrence of rare heart attacks

NCT ID NCT04496687

Knowledge-focused Sponsor: SCAD Alliance Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This international registry is collecting information from 2000 people who have had spontaneous coronary artery dissection (SCAD), a rare cause of heart attacks. Researchers will track participants' health over time to better understand the condition and develop best practices for prevention. The study is observational, meaning no new treatments are being tested.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this registry could lead to better guidelines for preventing SCAD and its recurrence.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test any therapy. Results depend on data quality and may take years to influence practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

2,000 people

The number who actually took part.

Started

Mar 2019

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Spontaneous coronary artery dissection (SCAD) is defined as the non-traumatic, non-iatrogenic separation of the coronary arterial wall by intramural hemorrhage creating a false lumen, with or without an intimal tear. SCAD nearly always presents as an acute myocardial infarction. The prevalence of SCAD varies depending on the population studied. A goal of iSCAD Registry is to expand diversity of race, ethnicity, and sex of study participants. The mean age of SCAD presentation is 45-53 years of age, and appears to primarily affect women.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either: 1. Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or 2. Outpatient cardiovascular clinics of enrolling medical centers. Participants must be: * 18 years of age or older * Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA * Suspected SCAD by coronary angiography Exclusion Criteria: 1. Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury 2. Inability to provide informed consent 3. Inability to complete study-related patient questionnaires 4. Inability to understand and complete patient questionnaires independently

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome Death, Sudden, Cardiac idiopathic spontaneous coronary artery dissection myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spontaneous coronary artery dissection

Contacts and locations

Locations

  • Allegheny General Hospital, Allegheny Health Network

    Pittsburgh, Pennsylvania, 15212, United States

  • Atrium Health Sanger Heart and Vascular Institute

    Charlotte, North Carolina, 28204, United States

  • Catholic Medical Center

    Manchester, New Hampshire, 03102, United States

  • Cedars Sinai

    Los Angeles, California, 90048, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Dartmouth-Hitchcock

    Lebanon, New Hampshire, 03756, United States

  • Emory Healthcare System

    Atlanta, Georgia, 30308, United States

  • Hartford Hospital

    Hartford, Connecticut, 06106, United States

  • Inova Heart & Vascular Institute

    Fairfax, Virginia, 22031, United States

  • Intermountain

    Murray, Utah, 84107, United States

  • Johns Hopkins

    Baltimore, Maryland, 21224, United States

  • Kaiser Permanente Northern California

    San Francisco, California, 94115, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114-2696, United States

  • Mount Sinai

    New York, New York, 10029-6574, United States

  • Northwestern Medicine

    Chicago, Illinois, 60611, United States

  • Oklahoma Heart

    Oklahoma City, Oklahoma, 73120, United States

  • Providence

    Portland, Oregon, 97225, United States

  • St. Luke's Mid America

    Kansas City, Missouri, 64111, United States

  • UCLA (University of California, Los Angeles)

    Los Angeles, California, 93003, United States

  • UT Southwestern

    Dallas, Texas, 75390, United States

  • University Hospitals--Case Western

    Cleveland, Ohio, 44106, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Kentucky

    Lexington, Kentucky, 40508, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of South Florida

    Tampa, Florida, 33602, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • University of Washington Medicine

    Seattle, Washington, 98195, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Victor Chang Cardiac Research Institute

    Darlinghurst, New South Wales, NSW 2010, Australia

  • Washington University

    St Louis, Missouri, 63110, United States

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