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Scientists hunt for genetic clues behind rare heart condition SCAD

NCT ID NCT03876847

Knowledge-focused Sponsor: Intermountain Health Care, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find genetic factors that increase the risk of spontaneous coronary artery dissection (SCAD), a rare heart condition where a tear in a blood vessel can cause a heart attack. Researchers will analyze DNA from 100 people who have had SCAD and compare it to people without the condition. The goal is to better understand what causes SCAD and identify potential genetic markers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2016

Expected to finish

Dec 2036

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will be Intermountain Healthcare patients. The case subjects will be SCAD patients and the control population for the genetics will be Intermountain angiography patients without SCAD.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: SCAD Cases 1. Subjects of all ages, gender, or race 2. Subjects had coronary angiography. 3. Subjects had suspected SCAD as based on clinical report. Controls 1. INSPIRE subject that had coronary angiography at Intermountain Healthcare for stable angina. 2. Subjects had no or mild atherosclerotic heart disease at time of angiography. 3. Age at last visit as recorded in the Intermountain EDW at least 50 years or older. 4. Not screened as possibly having a SCAD or coronary artery dissection diagnosis. Exclusion Criteria: SCAD Cases 1. Independent review of cardiac imaging and clinical presentation by three cardiologists determine the coronary angiography was not a result of SCAD. 2. Imaging from time of coronary angiography of poor quality as to not allow for proper determination of SCAD. 3. Inability to determine criteria as outlined above. 4. Subjects that have had a heart transplant. 5. Subjects that have had a bone marrow transplant. 6. Inability or refusal of the patient and/or the patient's legally acceptable representative to provide informed consent or blood sample for any reason. 7. Other conditions that in the opinion of the Principal Investigator may increase risk to the subject and/or compromise the quality of the trial. Controls 1. Subjects that have a heart transplant. 2. Subjects that have a bone marrow transplant. 3. Subjects with any of the following diagnosis at anytime 1. Heart failure 2. Heart valve disease 3. Thoracic aortic aneurysm and dissection 4. Ehlers-Danlos syndrome 5. Shprintzen-Goldberg syndrome 6. Marfan syndrome 7. Loeys-Dietz aortic aneurysm syndrome 8. Arterial tortuosity syndrome

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Conditions

The condition(s) this trial relates to.

idiopathic spontaneous coronary artery dissection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spontaneous coronary artery dissection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.