New strategy aims to predict heart attacks before they happen
NCT ID NCT06013722
First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times
Summary
This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if plaques are changing. The goal is to learn how to better prevent future heart attacks by catching problems early.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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22 people
The number who actually took part.
- Started
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Mar 2024
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 79 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with no coronary history presenting to the emergency room, to the assessment unit or having consulted in the cardiology department for suspicious chest pain that does not allow an acute coronary syndrome or angina to be excluded and: * in whom the diagnosis of acute coronary syndrome has been ruled out on the basis of clinical, electrocardiographic, biological monitoring, or even by imaging (including coronary angiography), in accordance with recommendations and good practices * in whom effort myocardial ischemia is rendered unlikely on the basis of a clinical and paraclinical evaluation (either ergometric or by functional imaging: scintigraphy, echography or stress MRI) * wishing diagnostic care and primary prevention of coronary disease. * Age above or equal to 18 and strictly below 80 years old * Having given informed consent Exclusion Criteria: * Pregnant woman * Patient with cognitive disorders * Claustrophobic patient, or refusing radiological examinations * Patient refusing cardiological follow-up and/or treatment of his risk factors or refusing to participate in the study * Patient with contraindications or intolerances to HMG-CoA reductase inhibitors (statins) and/or Ezetimibe * Patient with liver failure * Patient with myopathy or with a history of (rhabdo)myolysis * Marked arrhythmia and in particular supraventricular or ventricular hyperexcitability, or chronic or paroxysmal atrial fibrillation not controlled by antiarrhythmic treatment * Patients with a history of sternotomy or valve replacement or metallic intracardiac probes, generators of scanner artefacts * Calcium score corresponding to the percentiles of groups I and II * For patients in groups III and IV: * renal insufficiency with glomerular filtration rate estimated by the MDRD and/or CKD-EPI formula less than or equal to 55 ml/min/1.73 m2, * known intolerance to radiological contrast products, or in whom an injected CT scan has already been performed in the 6 months preceding inclusion * Person participating in another biomedical research * Person under judicial protection (guardianship, curatorship...) * Person deprived of liberty by a judicial or administrative decision.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier Princesse Grace
Monaco, 98000, Monaco
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Other studies related to the condition(s) this trial covers.
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