UK trial aims to repurpose existing drugs for rare and Hard-to-Treat cancers
NCT ID NCT07440290
Summary
This trial is testing if two already-approved cancer drugs, dabrafenib and trametinib, can help patients with rare cancers or common cancers that have a rare, specific genetic change called a BRAF V600 mutation. The drugs are already used for some cancers like melanoma, but researchers want to see if they work for many other cancer types with the same mutation. The goal is to provide new treatment options for adults and children with these hard-to-treat cancers by matching the drug to the patient's specific genetic profile.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Addenbrooke's Hospital
Cambridge, CB2 OQQ, United Kingdom
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Alder Hey Hospital
Liverpool, L14 5AB, United Kingdom
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Belfast City Hospital
Belfast, BT9 7AB, United Kingdom
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Birmingham Children's Hospital
Birmingham, B4 6NH, United Kingdom
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Bristol Haematology and Oncology Centre
Bristol, BS2 8ED, United Kingdom
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Bristol Royal Hospital for Children
Bristol, BS2 8BJ, United Kingdom
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Cardiff Children's Hospital
Cardiff, CF14 4XW, United Kingdom
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Churchill Hospital
Oxford, OX3 7LE, United Kingdom
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Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Freeman Hospital
Newcastle, NE7 7DN, United Kingdom
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Great North Children's Hospital
Newcastle, NE1 4LP, United Kingdom
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Great Ormond Street Hospital
London, WC1N 3JH, United Kingdom
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Guy's Hopsital
London, SE1 9RT, United Kingdom
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John Radcliffe Hospital
Oxford, OX3 9DU, United Kingdom
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Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
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Royal Hospital for Children Glasgow
Glasgow, G51 4TF, United Kingdom
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Royal Manchester Children's Hospital
Manchester, M13 9WL, United Kingdom
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Sheffield's Children's Hospital
Sheffield, S10 2TH, United Kingdom
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Southampton General Hospital
Southampton, United Kingdom
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The Beatson Hospital
Glasgow, G12 OYN, United Kingdom
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The Christie Hospital
Manchester, M20 4BX, United Kingdom
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The Royal Marsden Hospital
Sutton, SM2 5PT, United Kingdom
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University College London Hospital
London, NW1 2BU, United Kingdom
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University Hospital Birmingham
Birmingham, B15 2TT, United Kingdom
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Velindre Cancer Centre
Cardiff, CF14 2TL, United Kingdom
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Western General Hospital
Edinburgh, EH4 2XU, United Kingdom
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Weston Park Hospital
Sheffield, S10 2SJ, United Kingdom
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Conditions
Explore the condition pages connected to this study.