West China Hospital

This early-stage study tests a new vaccine called YMN-136 in 9 people with advanced colorectal cancer that has spread to the liver and no longer responds to standard treatments. The main goals are to check the vaccine's safety and find the best dose. Researchers will also watch f…

This study tests a new device designed to help the aorta heal better after emergency surgery for a life-threatening tear (type A aortic dissection). About 198 adults who recently had this surgery will either receive the device or continue standard care. The goal is to see if the …

This study tests whether adding a powerful cholesterol-lowering drug (PCSK9 inhibitor) to standard statin therapy can stabilize artery plaques in 212 people who recently had a heart attack. Participants will receive either the added drug or standard care for 6 months, and doctors…

This study tests whether adding desiccated thyroid extract (DTE) to standard levothyroxine can help intermediate-to-high risk thyroid cancer patients reach their TSH suppression targets faster and more safely. About 646 adults who have had surgery for differentiated thyroid cance…

This early-phase study tests a new mRNA treatment (NCP-IL-22BP mRNA) in 9 people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors to help the body fight cancer. The main goal is to check safety, and researche…

This study tests two drugs, Becotatug vedotin and Pucotenlimab, as a first treatment for people whose nasopharyngeal cancer has come back or spread. About 30 adults aged 18-75 with advanced disease will receive the combination. The goal is to see if it slows cancer growth and is …

This early-phase study tests whether injecting tiny tantalum particles into tumors before radiation is safe for people with a rare, returning soft tissue sarcoma in the abdomen. Nine adults with specific sarcoma types will receive increasing doses to find the safest level. The go…

This early-phase study tests whether a diet very low in vitamin B6 can make immunotherapy work better for people with solid tumors. About 20 adults aged 18-80 will follow this special diet for 6 weeks while continuing their regular immunotherapy. The main goal is to check if the …

This early-phase study tests a new mRNA drug that targets and clears faulty immune cells (B cells and plasma cells) in people with relapsed autoimmune diseases. The goal is to reset the immune system and reduce symptoms. About 27 adults aged 18-70 will receive the treatment to ch…

This study tests whether adding focused radiation (SBRT) and an immunotherapy drug (serplulimab) to standard chemotherapy can help people with advanced pancreatic cancer live longer. About 198 adults who have not had prior treatment for their metastatic disease will be randomly a…

This early-stage trial tests a therapeutic mRNA vaccine designed to target cancer-associated fibroblasts (CAFs) in patients with advanced solid tumors that have not responded to standard treatments. The vaccine works by helping the immune system recognize and attack these support…

This study is for people with HER2-positive advanced stomach cancer whose disease has worsened after two standard treatments. It tests a combination of a targeted drug (disitamab vedotin), an immunotherapy, and a special type of radiation. The goal is to see if this approach can …

This study looks at 100 adults with liver cancer that was initially too advanced for surgery but improved after conversion therapy. Researchers want to see if having surgery or continuing maintenance therapy is better at preventing the cancer from coming back. The goal is to help…

This study tests whether a spray containing superoxide dismutase (SOD) can prevent severe skin burns (radiation dermatitis) in people receiving radiation for head and neck cancer. About 140 participants will use the spray during their radiation treatment. The goal is to see if it…

This study tests whether adding a bile acid pill (UDCA) to standard treatment can prevent serious brain confusion (hepatic encephalopathy) after a liver shunt procedure called TIPS. About 270 adults with cirrhosis will receive either UDCA plus lactulose or lactulose alone for 3 m…

This study tests whether a spirulina-based product can prevent severe esophagitis (painful swallowing) in 70 esophageal cancer patients receiving radiation therapy. Participants will take the supplement during treatment to see if it lowers the chance of needing strong painkillers…

This study compares two ways to recover after knee surgery for a discoid meniscus: standard in-clinic rehab versus using a wearable device and remote guidance at home. Sixty people aged 10 to 60 will be randomly assigned to one of the two groups and followed for six months. The g…

This study tests a new anti-fog drainage device that helps keep the camera lens clear during endoscopic pituitary tumor surgery. About 20 adults with pituitary adenoma or craniopharyngioma will either get the device or the usual water-squirt method. Researchers will measure how m…

This study looks back at medical records to see how parathyroid surgery changed quality of life for 60 adults with kidney failure and high calcium levels. Researchers will check surveys on physical and mental health, anxiety, and depression. The goal is to understand if the surge…

This study reviews medical records of 700 adults with severe pancreatitis and sepsis who had surgery to remove dead tissue. Researchers want to see how organ function changes after the operation. No new treatment is being tested; the goal is to learn more about recovery patterns.