University Of Toronto

This study tests whether a digital heart health program (a web app, online classes, and special foods) added to usual care can lower cholesterol and reduce heart attacks in people with heart disease or risk factors. About 1,100 participants will be randomly assigned to the progra…

This pilot study tests whether adding the HIV drug efavirenz to a person's current antiretroviral therapy (ART) can kill cells that harbor hidden HIV. About 26 adults with HIV who have low but detectable virus levels despite good adherence will take efavirenz for 8 weeks. The goa…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This study looks at how exercise and diet affect heart health in women with metabolic issues. Researchers will compare exercise alone, exercise plus diet advice, and stretching in 180 pre- and postmenopausal women over 6 months. The goal is to see which approach best reduces insu…

This study looks at whether exercise and healthy eating can reduce heart disease risk in women who have had breast cancer. 45 postmenopausal survivors will be placed into one of three groups: exercise, exercise plus diet counseling, or stretching. The goal is to see if these life…

This study looks at whether eating three servings of dairy each day (like milk, yogurt, and cheese) can help overweight teens (ages 15-18) and seniors (ages 60-80) improve their body weight, body composition, and blood sugar levels over six months. Participants are randomly assig…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study tests whether adding behavioural counselling to a virtual supervised exercise program helps cancer survivors stay physically active. About 236 survivors who have finished primary cancer treatment will be split into two groups: one gets standard exercise advice, the oth…

This study tests a 6-week group therapy program for adults with schizophrenia or related disorders. The therapy focuses on changing negative core beliefs (like feeling worthless or that others are dangerous) using compassion-focused techniques. The goal is to see if this approach…

This study looks at 50 adults having knee replacement revision surgery. It compares two groups: one gets spinal morphine for pain, the other does not. Both groups receive nerve blocks. The goal is to see if skipping morphine lowers the chance of needing a urinary catheter after s…

This study looks at whether a 16-week cardiac rehabilitation exercise program can improve heart health and fitness in women who have had early-stage breast cancer. About 100 participants will take part in the program at the Toronto Rehabilitation Institute. Researchers will measu…

This study tests an online program called SCI&U that pairs people with spinal cord injury (SCI) with trained peer health coaches. The goal is to help those recently discharged from the hospital feel less emotional distress and gain confidence in managing their own health. Partici…

This study compares two simple physical activity strategies—short walks after meals and brief activity snacks—to standard 30-minute exercise sessions in breast and prostate cancer survivors. The goal is to see which approach best controls blood sugar and is easiest to fit into da…

This study tests whether a non-invasive breath test can accurately measure how the body builds muscle after eating protein, compared to the current gold-standard method that requires muscle biopsies. Eight healthy adults will drink protein shakes with special tracers, then provid…

This study looks at the brains of 45 toddlers (18-30 months old) who are late talkers. Researchers use sleep brain scans to see how language treatment changes connections in memory and language areas. The goal is to better understand why some children struggle with language and h…

This study looks at how easy and enjoyable different exercise programs are for women in perimenopause—the years leading up to menopause. Researchers will compare following standard physical activity guidelines, doing high-intensity interval training (HIIT), or stretching over 6 w…

This study looks at whether doing sprint interval training during different phases of the menstrual cycle (follicular vs. luteal) changes how well your body adapts. Researchers will measure endurance performance and muscle changes in 24 healthy women who exercise regularly. The g…

This study looks at how fast healthy adults convert EPA (an omega-3) into DHA, and whether biological sex or a specific gene (ELOVL2) influences this process. Participants take EPA supplements for 12 weeks and give blood samples. The goal is to understand individual differences i…

This study compares two rehabilitation methods to improve finger movement in 40 people who had a stroke. One method encourages using any strategy to reach goals, while the other focuses on improving movement technique. Participants will do 10 days of piano training and have brain…

This study looks at how natural menstrual cycles and birth control pills change the way women build muscle after weightlifting. Researchers will measure muscle protein synthesis in 20 recreationally active women after exercise and a protein drink. The goal is to provide better tr…

This study looks at how a common breast cancer treatment called aromatase inhibitors affects the heart and blood vessels in the first 6 months. Researchers will compare 40 women with breast cancer to healthy women of similar age and weight. The goal is to find early warning signs…