University Of Toronto

This trial compares two parenting programs for caregivers who have depression and are seeking help for their child's emotional or behavioral difficulties. The experimental program, ADAPT, is designed to address the unique emotional needs of depressed parents, while the control is…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This pilot study tests whether adding the HIV drug efavirenz to a person's current antiretroviral therapy (ART) can kill cells that harbor hidden HIV. About 26 adults with HIV who have low but detectable virus levels despite good adherence will take efavirenz for 8 weeks. The goa…

This study looks at whether eating three servings of dairy each day (like milk, yogurt, and cheese) can help overweight teens (ages 15-18) and seniors (ages 60-80) improve their body weight, body composition, and blood sugar levels over six months. Participants are randomly assig…

This study tests whether a digital heart health program (a web app, online classes, and special foods) added to usual care can lower cholesterol and reduce heart attacks in people with heart disease or risk factors. About 1,100 participants will be randomly assigned to the progra…

This study tests whether following exercise and healthy eating guidelines can improve heart health and reduce metabolic problems in breast cancer survivors. Forty-five postmenopausal women who had breast cancer will be split into three groups: exercise only, exercise plus dietary…

This study is testing whether a 16-week cardiac rehabilitation exercise program can improve heart health in women who have had early-stage breast cancer. One hundred participants will take part in the program, and researchers will measure changes in fitness, heart function, and q…

This study tests whether an 8-week habit-based program can help cancer survivors reduce the time they spend sitting or lying down during the day. Participants receive weekly tips, check-in sessions, and a Fitbit to encourage more movement. The goal is to see if the program is pra…

This study looks at whether the timing of a 9-hour eating window (early, mid, or late in the day) affects blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Over 7 days, 120 participants will follow one of three time-restricted eating schedule…

This study tests a 6-week group therapy program for adults with schizophrenia or related disorders. The therapy focuses on changing negative core beliefs (like feeling worthless or that others are dangerous) using compassion-focused techniques. The goal is to see if this approach…

This study looks at whether skipping intrathecal morphine during knee revision surgery can lower the chance of needing a catheter for urinary retention. Fifty adults having non-infected knee revision will get either morphine or a placebo alongside standard nerve blocks. The goal …

This study compares two simple physical activity strategies—short walks after meals and brief activity snacks—to standard 30-minute exercise sessions in breast and prostate cancer survivors. The goal is to see which approach best controls blood sugar and is easiest to fit into da…

This study tests whether adding motivational counselling to a supervised virtual exercise program helps cancer survivors stay physically active. 236 survivors who have finished primary cancer treatment will be split into two groups: one gets standard exercise advice, the other ge…

This study tests whether an online program called SCI&U, which pairs people with trained peer health coaches, can help those recently discharged from inpatient rehab after a spinal cord injury. Participants will have up to 14 one-hour video sessions covering health topics like bl…

This study uses brain scans to understand how early language intervention changes the brains of toddlers (18-30 months) who are late talkers. Researchers will scan 45 children before and after a parent-led speech therapy program to see if brain connections linked to learning and …

This study compares two rehabilitation methods to improve finger movement in 40 people who had a stroke. One method encourages using any strategy to reach goals, while the other focuses on improving movement technique. Participants will do 10 days of piano training and have brain…

This study looks at how fast healthy adults convert EPA (an omega-3) into DHA, and whether biological sex or a specific gene (ELOVL2) influences this process. Participants take EPA supplements for 12 weeks and give blood samples. The goal is to understand individual differences i…

This study tests whether a non-invasive breath test can accurately measure how the body builds muscle after eating protein, compared to the current gold-standard method that requires muscle biopsies. Eight healthy adults will drink protein shakes with special tracers, then provid…

This study looks at how natural menstrual cycles and oral contraceptive use affect muscle protein synthesis after resistance training. Twenty recreationally active women will consume protein drinks and undergo muscle biopsies to measure protein building. The goal is to understand…

This study tracks 40 postmenopausal women with hormone-positive breast cancer who are starting aromatase inhibitor therapy. Researchers will measure heart and blood vessel health, blood markers, body composition, and lifestyle factors over 6 months, comparing them to healthy wome…

This study looks at how exercise and healthy eating affect heart and metabolic health in women with multiple risk factors. Researchers will follow 180 pre- and postmenopausal women for 6 months, comparing exercise alone, exercise plus diet advice, and a stretching group. The goal…

This pilot study from the University of Toronto is testing how easy and enjoyable three different exercise programs are for women in perimenopause—the years leading up to menopause. The programs include moderate-intensity exercise, high-intensity interval training (HIIT), and str…