Knee surgery painkiller linked to catheter need – new trial seeks safer option

NCT ID NCT07050277

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether skipping intrathecal morphine during knee revision surgery can lower the chance of needing a catheter for urinary retention. Fifty adults having non-infected knee revision will get either morphine or a placebo alongside standard nerve blocks. The goal is to see if pain control stays good while avoiding bladder complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Intrathecal morphine
What this could lead to
If successful, this could show that skipping intrathecal morphine during knee revision surgery lowers the risk of needing a catheter without worsening pain.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. The study is still recruiting, and the outcome is uncertain.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Mount Sinai Hospital

    RECRUITING

    Toronto, Ontario, M5G 1X5, Canada

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