University Hospitals Cleveland Medical Center

This study compares two methods of closing the breastbone after open heart surgery: rigid plates versus traditional wires. It involves 250 adults at high risk for wound problems, such as those with diabetes or obesity. The goal is to see which technique leads to better bone heali…

This study looks at whether a community health worker (CHW) can act as a diabetes technology coach for Black children with type 1 diabetes who use an automated insulin delivery system but still have high blood sugar (HbA1c of 8% or higher). Over 6 months, families meet monthly wi…

This study tests if milk thistle, an herbal supplement, can improve fatty liver disease in children aged 9 to 22. It offers an easier alternative to strict diet and exercise. Researchers will measure liver health through blood tests and scans. The goal is to find a simpler treatm…

This study looks at whether eating a Mediterranean diet can improve psoriasis symptoms in people who are about to start a biologic medication (anti-IL-17 or anti-IL-23). About 36 adults with moderate to severe psoriasis will be randomly assigned to follow the diet or not. The goa…

This study looks at whether using a home blood pressure monitor can accurately diagnose high blood pressure in African American teenagers, who are at higher risk. Researchers will compare home readings with a 24-hour monitor that is the current best method. The goal is to find a …

This study tests whether an AI tool can accurately detect lung nodules on chest X-rays. About 46,000 chest X-rays will be analyzed by both AI and radiologists to see how well they agree. The goal is to see if AI can help speed up and improve the detection of potentially serious l…

This study compares a new DNA-based test (PCR) to the standard urine culture for diagnosing urinary tract infections (UTIs) in adults. Participants are randomly assigned to one test group and tracked for up to 21 days. The goal is to see if the faster DNA test leads to quicker tr…

This study looks at whether a digital platform called Band Connect helps people recovering from shoulder surgery or rotator cuff repair do their home exercises more consistently. About 500 adults aged 18 to 89 will use the platform, and researchers will track how many exercises t…

This study tests whether a numbing injection (erector spinae plane block) given before lumbar spine fusion surgery can better control pain and reduce the need for pain medication. About 32 adults having back fusion will receive the injection plus a contrast dye to see where the m…

This study compares two procedures—a sling or a bulking injection—to treat stress urinary incontinence in women undergoing vaginal prolapse repair. About 476 participants will be randomly assigned to one procedure and followed for 24 months. The goal is to see which approach bett…

This study is testing a new group music therapy program called POPSINGER for adults with chronic pain. The program is a mix of in-person and online sessions. Researchers want to see if people find it helpful and easy to stick with. About 24 adults will take part.

This study tests whether learning simple mindfulness exercises (like deep breathing and staying focused on the present) before colorectal surgery can help people feel calmer and manage pain better afterward. About 50 adults will be randomly assigned to either a mindfulness sessio…

This study helps people with ongoing back pain after surgery compare two treatments: spinal cord stimulation (a device that sends electrical pulses) and a pain pump (which delivers medicine directly to the spine). Participants try both treatments temporarily and choose which one …

This study tests a new surgical method for gender-affirming vaginoplasty that uses a fish skin graft (Kerecis™) to line part of the new vagina. The goal is to see how well the graft heals and how it affects quality of life, pain, and sexual function. Up to 20 transgender women wi…

This study looks at whether adding acupuncture to simple behavioral changes can help women with bladder pain syndrome (interstitial cystitis) who haven't had other treatments. 34 women will either make behavioral changes alone or also receive weekly acupuncture for 6 weeks. Resea…

This study is for adults with epilepsy who have repeated seizures. Researchers are testing a program that teaches people how to use rescue medication to stop seizures. The goal is to see if the program reduces seizures and improves quality of life. About 30 people will take part …

This study tests whether a vaginal estrogen cream can improve sexual function in breastfeeding women who are 6 weeks to 6 months postpartum. About 100 sexually active women who had a full-term birth and plan to breastfeed will use the cream or not. The goal is to see if the cream…

This study compares two surgeries for people with severe, irreparable rotator cuff tears: partial repair alone versus partial repair plus a graft to rebuild the shoulder's natural support. Researchers will track pain, function, and quality of life in 105 adults over two years. Th…

This study tests a prediction model to help doctors decide when antibiotics are truly needed for urinary tract infections (UTIs) in the emergency room. About 47 women discharged from the ER with a UTI diagnosis will be enrolled. The goal is to reduce unnecessary antibiotic use an…

This study aims to find gene patterns that can predict how well a person with psoriasis will respond to certain FDA-approved drugs. About 56 participants will try two different psoriasis medications for 8 weeks each, while researchers take blood and skin samples. The goal is to m…

This study looks at two methods of recovering blood from sponges used during heart and lung surgeries: wringing them by hand or using an automated suction device. About 20 adults having major heart or lung surgery will take part. The goal is to see which method keeps red blood ce…

This study is checking if a blood test called phosphatidylethanol (PEth), which shows how much alcohol someone has had in the past few weeks, can help predict problems after surgery. Researchers will test 170 adults who drink alcohol and are having surgery that requires a hospita…

This study tests a wearable sensor that measures muscle oxygen levels in high school and college athletes recovering from ACL or hip surgery. The goal is to see if the sensor can give doctors better data to decide when it's safe for athletes to return to play. About 226 participa…

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) in people with aortic stenosis. Researchers will use exercise MRI to see which valve performs better during physical activity. About 90 adults who need a valve replacement will parti…

This study uses eye-tracking technology to measure how people with bipolar disorder pay attention, respond to rewards, and control their thoughts. Researchers will compare different groups, including those with anxiety or substance use issues. The goal is to better understand the…

This study compares two imaging methods—cardiac CT and transesophageal echocardiogram (TEE)—for checking a heart device called Watchman FLX after it's placed to prevent strokes. About 320 adults will get both tests 90 days after their procedure to see which method better detects …

This study looks at whether giving extra prenatal resources, like a 'care box,' to pregnant patients in the emergency room helps them attend follow-up OBGYN appointments and feel more confident about their pregnancy. About 50 participants will be randomly assigned to receive the …

This study looks at whether a 'teach-back' education method helps people who had surgery for broken bones in their pelvis or legs remember their injury and treatment instructions. About 216 participants will either receive this extra education or not. Researchers will measure how…