University Hospital, Tours

This study tested whether a 6-week course of antibiotics works as well as the standard 12-week course for treating infections in hip or knee joint replacements. Over 400 adults in France took part, all receiving surgery to clean or replace the infected joint. The goal was to see …

This study tested whether adding the drug rituximab to standard care could stop acute rejection in kidney transplant patients. 40 adults who had a kidney transplant within the past year and showed signs of acute humoral rejection took part. The main goal was to see if rituximab c…

This study looked at two types of stents used in a procedure called TIPS, which creates a bypass in the liver to relieve complications of cirrhosis. One stent is covered with a special material to stay open longer but costs more; the other is a standard bare stent that is cheaper…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study tested whether adding rituximab to standard mycophenolate mofetil (MMF) therapy improves lung function in adults with interstitial lung disease (lung scarring) who did not respond to initial treatment. About 122 participants received either rituximab plus MMF or a plac…

This study tested whether people with a serious heart valve infection (endocarditis) could safely switch from IV antibiotics to oral pills after at least 10 days of IV treatment. The trial involved 324 adults with left-sided endocarditis caused by certain bacteria. The goal was t…

This study tested the drug sirolimus in 63 children aged 6 to 18 with large, complicated slow-flow vascular malformations (abnormal clusters of blood or lymph vessels). The goal was to see if sirolimus could shrink the malformations and ease symptoms like pain, bleeding, and swel…

This study tested whether adding a low-dose steroid (hydrocortisone) to standard care could help people with severe community-acquired pneumonia survive. Over 900 critically ill adults in intensive care took part. The goal was to see if the steroid reduced deaths within 28 days.

This study tested a daily dab of sirolimus solution on the tongue for people with a rare condition causing fluid-filled cysts on the tongue. The goal was to see if it could reduce symptoms like oozing, bleeding, and trouble eating or speaking. Twelve children and adults used the …

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This study tested whether having COVID-19 patients with serious breathing problems lie face down (prone position) while receiving high-flow oxygen could reduce the need for a breathing tube. Researchers enrolled 405 adults with COVID-19 pneumonia and acute respiratory distress sy…

This study tested whether a continuous glucose monitor could help manage low blood sugar (hypoglycemia) in very low birth weight newborns. 48 preterm infants were randomly assigned to either real-time continuous monitoring or standard finger-stick tests for the first three days o…

This study tested a cream containing sirolimus on rare skin growths called microcystic lymphatic malformations, which can ooze, bleed, and cause pain. 55 children and adults applied the cream to one area and a placebo cream to another for 12 weeks. The goal was to see if the siro…

This study looked at whether patients with a serious heart infection (endocarditis) caused by staph bacteria can safely switch from intravenous (IV) antibiotics to oral pills after initial treatment. The trial involved 162 adults with left-sided heart valve infections who were st…

This study tested whether people with HIV who have a low viral load and a strong immune system can safely switch from a three-drug regimen to a two-drug regimen. The goal was to keep the virus under control while reducing side effects and treatment costs. The trial involved 224 p…

This study tested whether a painless, radiation-free chest ultrasound can spot early signs of lung disease in people with systemic scleroderma, a condition that often leads to deadly lung scarring. Researchers studied 30 adults who had no detectable lung damage on standard CT sca…

This study looked at whether tears and cells from the eye's surface can help diagnose amyotrophic lateral sclerosis (ALS), a nerve disease that affects movement. Researchers compared samples from 55 people with ALS and healthy controls to find unique chemical fingerprints. The go…

This study tested a new high-frequency ultrasound probe to see if it can measure gum pocket depth as accurately as the standard manual probing method for diagnosing periodontal disease. Thirty-nine adults participated, and researchers compared measurements from both methods. The …

This study looked at whether a dye called iohexol can be used to measure kidney function in intensive care unit (ICU) patients with unstable kidneys. About 100 adults with acute circulatory failure took part. The goal was to see if tracking how fast the body clears the dye gives …

This study tested whether a special ultrasound with contrast dye (CEUS) can accurately identify liver lesions found on regular ultrasound. Researchers compared CEUS to CT, MRI, and biopsy in 878 adults. The goal was to see if CEUS could provide a cheaper, safer, and equally relia…

This study tested whether a special ultrasound using contrast dye can better diagnose placenta accreta, a condition where the placenta grows too deeply into the womb and can cause severe bleeding after birth. Researchers studied 80 pregnant women at high risk for this condition. …

This study tested a weekly oral antibiotic program to prevent urinary tract infections (UTIs) in 45 adults with neurogenic bladder (a bladder that doesn't work normally due to nerve damage). Participants took a single dose of one antibiotic on even weeks and a different antibioti…

This study tested whether a 3-day course of inhaled amikacin could prevent ventilator-associated pneumonia (VAP) in adults who had been on a breathing machine for at least 3 days. A total of 850 patients from multiple hospitals were randomly assigned to receive either the drug or…

This study tested a two-step pneumococcal vaccine approach in 26 patients with diffuse large B-cell lymphoma who were receiving chemotherapy with rituximab. The goal was to see if giving two different vaccines in sequence could boost protection against serious pneumococcal infect…

This study tested whether taking low-dose aspirin (160 mg) at bedtime, starting early in pregnancy (before 16 weeks), could prevent pre-eclampsia and small babies in first-time mothers at high risk. Over 1,100 women with abnormal blood flow in the uterine artery participated. The…

This study looked at 334 ICU patients with severe lung failure (ARDS) who needed to lie on their stomachs to help them breathe. Researchers compared two ways of positioning their arms—either by their sides or in a 'swimmer's pose'—to see which caused fewer severe bedsores. The go…

This study tested two ways to prepare the cervix for labor in women whose pregnancies lasted 41 weeks or more. One method uses a medication (Propess), the other uses a soft balloon device placed in the cervix. The goal was to see if the balloon method leads to fewer emergency C-s…

This study looked at whether a one-hour dose of nitrous oxide (laughing gas) can quickly reduce depression symptoms in older adults (ages 60-90) whose depression hasn't improved with standard treatments. Sixty participants received either the gas or a placebo (medical air) and we…

This study looked at whether daily training with different odors can improve how people with mild or major depression perceive smells and emotions. Researchers enrolled 150 participants, including healthy volunteers and depressed patients, who practiced smelling various scents ov…

This study looked at two different surgical methods for fixing hip fractures in people over 65. The goal was to see if a newer, less invasive method (MISS) causes less blood loss than the standard method (PHS). The study involved 108 participants and measured blood loss from the …

This study looked at whether giving the drug salbutamol (often used in asthma inhalers) through a nebulizer helps people with severe COPD who are having a flare-up and need a breathing machine. The trial included 43 adults and compared the drug to a placebo. The main goal was to …

This study tested a drug called Levetiracetam to treat seizures in newborn babies who had a brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe. 18 full-term babies took part. The results help doctors understand how to use this m…

This study tested whether adding a mild brain stimulation technique called tDCS to standard trauma-focused therapy can better reduce PTSD symptoms. 63 adults with chronic PTSD took part. The goal was to see if the stimulation helps the therapy work more effectively, offering a ne…

This study tested if a high-flow nasal system (AIRVO 2) can deliver the bronchodilator salbutamol as effectively as a standard mask for people with COPD. 25 adults with COPD and reversible airway blockage took part. The goal was to see if the new method works just as well at impr…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity who also have food addiction. 154 participants received either 12 therapy sessions over 18 weeks or standard care. The goal was to see if the therapy reduc…

This study looked at blood and bone marrow samples from 102 healthy volunteers aged 18 to 85 to see how age affects oxidative stress—a natural process in cells. Researchers measured reactive oxygen species and antioxidant gene activity to create a baseline for future studies on b…

This study looked at whether giving a written sheet to melanoma patients, to pass on to their close relatives, helps those relatives get a skin exam from a doctor. 420 patients and their family members took part. The goal was to see if the written reminder works better than just …

This study looked at 92 older adults with depression to see if their brains had amyloid plaques, which are linked to Alzheimer's disease. Researchers used a special PET scan to measure plaque levels in people whose depression got better, got somewhat better, or did not improve af…

This pilot study tested whether a portable ultrasound device can help paramedics quickly tell which type of stroke a person is having. The goal is to get patients to the right hospital faster—some need a clot-busting drug, others need a procedure to remove a large clot. The study…

This study looked at whether mindfulness meditation can change brain chemistry in areas linked to memory. Thirty female speech therapy students were split into two groups: one did mindfulness training, the other did muscle relaxation. Over 6 weeks, researchers measured brain meta…

This study explored whether analyzing the fluid used to preserve donor kidneys on a special machine can help predict how well the kidney will work after transplant. Researchers measured substances in the fluid and compared them to how the kidney functioned in the first week after…

This study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changed as the child grew, and watched for complications like blood vessel or bone problems. They also looked for genetic links and how the condition affected qual…

This study looked at whether a phone call from a medical student to older adults with heart disease or mental health conditions during the COVID-19 lockdown in France could reduce hospitalizations within a month. About 22,000 people took part. The goal was to see if this simple c…

This study looked at 69 adults with rheumatoid arthritis who were taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, i…

This study looked at 342 pregnant women to see if ultrasound measurements of the cervix could better predict the time from labor induction to delivery compared to the standard Bishop score. The goal is to improve care for women who need their labor started with medication. The st…

This study looked at how muscle cells produce energy in women with ovarian or endometrial cancer who have lost weight. Researchers compared women with different body mass indexes (BMI) to see if metabolism differs. The goal was to understand the biology behind cancer-related weig…

This study looked for biological markers in blood, urine, and saliva to understand why up to 40% of people with depression do not get better with standard antidepressants. Researchers studied 50 adults with major depression who had not taken antidepressants for at least two weeks…

This study tested whether advanced MRI and ultrasound techniques can better measure muscle changes in people with rotator cuff tears. Three adults with a tear on one side and a healthy shoulder on the other took part. The goal was to see if these imaging tools could provide clear…

This study looked at 220 adults with phenylketonuria (PKU), a rare genetic condition that requires a special diet from birth. Researchers wanted to see if adults with PKU experience mental decline or other brain problems, and how the disease affects their daily life and social in…

This study involved 2,200 adults who had a double J stent removed. Researchers wanted to find out if a standard urine test before removal actually helps prevent urinary infections afterward. Participants were followed for one month to track any infections. The goal was to see if …

This study looked at 400 people aged 60-90 having cataract surgery. Researchers compared white and yellow implants to see if the color affects sleep, mood, or daily rhythms. The goal is to learn whether filtering more blue light changes how well patients sleep.

This study looked at whether adults with phenylketonuria (PKU) have low-level inflammation throughout their bodies. Researchers measured inflammatory markers in the blood of 40 participants, including both PKU patients and healthy volunteers. The goal was to better understand how…

This study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked the number and severity of side effects over one year to see how they affect patients' daily lives and treatment success. The goal was to better understand…

This study followed 137 people who had severe COVID-19 pneumonia and needed high-flow oxygen in the ICU. Researchers checked their quality of life and survival more than 2 years after they were randomly placed on their stomachs while awake or not. The goal is to see if this simpl…

This study aims to validate a special MRI technique called tractography, which maps the brain's white matter connections. Researchers will compare MRI scans from 134 older adults (aged 82+) with actual brain tissue samples after donation. The goal is to ensure this non-invasive i…

This study looked at how energy use (metabolism) differs in people with ALS. Researchers took small skin samples and blood from 9 patients to study chemical changes. The goal was to learn more about the disease, not to test a new treatment.

This study looked at how the brain reacts to nitrous oxide (laughing gas) in 20 people with treatment-resistant depression and 10 healthy volunteers. Using ultrasound and MRI scans before, during, and after a one-hour treatment, researchers aimed to understand why some patients f…

This study looked for biological markers (biomarkers) in muscle, blood, and satellite cells from 37 people with ALS. The goal was to find patterns that could help diagnose ALS earlier and understand how the disease works. Researchers used advanced lab techniques to analyze the sa…

This study looked at whether waiting to place an arterial catheter (a thin tube in an artery to monitor blood pressure) in critically ill patients with shock is as safe as placing it right away. Over 1,000 adults in intensive care were randomly assigned to either early or delayed…

This study tested a new ultrasound device to measure skin stiffness (fibrosis) in people with lymphedema or venous insufficiency. Researchers compared results from 130 participants, including healthy volunteers, to see if the device could detect differences in skin hardness. The …

This study looked at how muscle energy works in 51 people with gastrointestinal cancer who were losing weight. The goal was to understand why cancer-related weight loss happens and find new ways to help. Researchers measured muscle cell energy use and fat storage, but this was an…

This study used a special brain scan (PET imaging) to look at how a chemical messenger called glutamate works in the brains of people with autism, people with Fragile-X syndrome, and healthy volunteers. The goal was to better understand brain signaling differences in these condit…

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared the gene variations in 188 patients who either improved or did not improve after 3 to 6 weeks of treatment. The goal is to better …

This study looked for tiny molecules called microRNAs in the blood of 33 men with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if certain microRNA patterns could predict whether a patient's cancer would resist chemotherapy or newer horm…

This study looked at two ways to encourage women who had not been screened for cervical cancer to get tested. One group received a self-sampling kit in the mail to test for HPV at home, while the other group was invited to visit their general practitioner for a Pap smear. The goa…

This study looked at 300 adults to better understand complex post-traumatic stress disorder (PTSD). Researchers used questionnaires to measure dissociation, emotional control, and trauma symptoms. The goal was to identify what makes complex PTSD different from regular PTSD, helpi…

This small study tested whether a device that delivers gentle thumping breaths (intrapulmonary percussion ventilation) can help inhaled medication reach scarred parts of the lungs in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a harmless radioactive…

This study tested whether holding regular, structured team meetings about ethics in the intensive care unit (ICU) helps nurses feel more included in decisions to limit or stop life support. Researchers measured changes in nurses' perception of the decision-making climate, their w…

This study looked at how people with current depression, those who have recovered from depression, and healthy people react physically to emotions. Researchers measured heart rate, breathing, skin sweat, and brain blood flow during emotional tasks. The goal was to understand diff…

This study looked for early warning signs in eye fluids that could predict if someone will develop dry eye or other surface problems after cataract surgery. Researchers collected tiny samples from the eye's surface and inner fluid from 100 adults having cataract surgery. They use…

This study tested a new ultrasound method called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements in healthy adults aged 18 and older. Researchers aimed to see how these movements change from young adulthood to old age. The study involved 53 participants a…

This study looked at how prostate tissue heals after a Greenlight laser treatment for benign prostatic hyperplasia (BPH), or enlarged prostate. Researchers used MRI and special ultrasound scans to measure the area of dead tissue created by the laser in 12 men over a year. The goa…