University Hospital, Tours

This study looked at whether people with a serious heart infection (endocarditis) caused by staph bacteria can safely switch from intravenous (IV) antibiotics to oral pills after an initial treatment period. 162 adults with left-sided heart infection were enrolled. The goal was t…

This study looked at whether using a continuous glucose monitor in real time could help manage low blood sugar in very low birth weight newborns. 48 babies were randomly assigned to either real-time monitoring or standard finger-prick testing during their first three days of life…

This study tested whether people with well-controlled HIV could safely switch from a three-drug regimen to a two-drug regimen (Truvada only) to reduce side effects and costs. It included 224 participants who had low levels of HIV in their body and strong immune systems. The goal …

This study looked at 410 adults with infected hip or knee replacements. All had surgery to clean or replace the joint. Half got 6 weeks of antibiotics, the other half got 12 weeks. The goal was to see if the shorter treatment works just as well to cure the infection without it co…

This study tested two ways to prepare the cervix for labor in women whose pregnancies lasted 41 weeks or more. One method uses a medicine (Propess), the other uses a soft balloon device. The goal was to see if the balloon method leads to fewer emergency C-sections due to signs of…

This study tested whether the drug rituximab can help treat a type of kidney rejection called humoral acute rejection in people who had a kidney transplant within the past year. The trial included 40 adults and measured if the treatment prevented graft loss or improved kidney fun…

This study looked at 138 people with cirrhosis who needed a TIPS procedure to relieve complications of high blood pressure in the liver. Researchers compared two types of stents: a newer, more expensive covered stent and a traditional bare stent. The goal was to see if the covere…

This study looked at whether chemicals in tears and eye cells can help diagnose ALS, a disease that affects nerve cells. Researchers compared samples from 55 people with and without ALS. The goal was to find biomarkers that could lead to a simple, non-invasive test for earlier di…

This study looked at whether a simple, painless chest ultrasound can find early signs of lung disease in people with systemic scleroderma. Lung disease is a major cause of death in scleroderma, and catching it early is key. The study included 30 adults with scleroderma who had no…

This study tested whether giving an inhaled antibiotic (amikacin) for three days could prevent ventilator-associated pneumonia (VAP) in ICU patients. 850 adults on breathing machines for at least 3 days received either the drug or a placebo. The goal was to see if the treatment r…

This study looked at whether a urine test before removing a double J stent (a tube that helps drain urine from the kidney) can prevent urinary infections afterward. Over 2,200 adults who were scheduled for stent removal took part. Researchers tracked how many people developed a u…

This study looked at blood and bone marrow samples from 102 healthy volunteers aged 18 to 85 to understand how age changes the balance of natural cell chemicals called reactive oxygen species. The goal was to create a reference for future research on blood diseases. No treatment …

This study looked at how muscle cells produce energy in women with ovarian or endometrial cancer who have lost weight. Researchers compared women of different body sizes (BMI) to see if muscle metabolism differs. No treatments were tested; the goal was simply to understand the ch…

This study looked at whether ultrasound measurements of the cervix can better predict the time between starting labor induction and giving birth, compared to the standard Bishop score. It included 342 women with a full-term, single pregnancy who had an unfavorable Bishop score. T…

This study looked at how muscles use energy in people with gastrointestinal cancer who are also malnourished. The goal was to better understand the body changes that cause muscle wasting. Researchers measured muscle cell energy activity and related factors in 51 patients. This wa…

This study looked at how mindfulness meditation affects brain chemistry and memory in 30 female speech therapy students. Participants were split into two groups: one practiced mindfulness meditation, the other did muscle relaxation exercises. Over 6 weeks, researchers measured br…

This study looked at whether a specific gene (BDNF) influences how well people with major depression respond to antidepressants. Researchers compared genetic differences between those who improved and those who did not after 3 to 6 weeks of treatment. The goal is to help doctors …

This study tested a new ultrasound technique called Fast Cerebral Pulsatility Imaging (FCPI) to measure tiny brain movements in healthy adults aged 18 and older. Researchers aimed to see how these brain pulsations change from young adulthood to old age. The study involved 53 part…

This study used a special brain scan (PET imaging) to measure how a chemical called glutamate works in the brains of 27 men with autism, Fragile-X syndrome, or no condition. The goal was to understand brain differences, not to test a treatment. Participants had one imaging sessio…

This study looked at whether a systematic phone call from a medical student, working with a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and olde…

This study looked at whether adults with phenylketonuria (PKU) have low-level body-wide inflammation. Researchers measured inflammatory markers in the blood of 40 participants (20 with PKU and 20 healthy volunteers matched by age, sex, and weight). The goal was to better understa…

This study looked at 33 men with advanced prostate cancer that no longer responded to hormone therapy. Researchers wanted to see if tiny molecules called microRNAs could predict which treatments—chemotherapy or newer hormone drugs—would stop working. The goal was to find biologic…

This study looked at whether waiting to place an arterial catheter (a tube in an artery to monitor blood pressure) is as safe as placing it early in ICU patients with severe low blood pressure. Over 1,000 adults were randomly assigned to either early or delayed catheter insertion…