BREATHING EASIER: inhaled antibiotic may ward off deadly pneumonia in ventilator patients

NCT ID NCT03149640

First seen Jan 05, 2026 · Last updated Apr 28, 2026 · Updated 18 times

Summary

This study tested whether giving an inhaled antibiotic (amikacin) for three days could prevent ventilator-associated pneumonia (VAP) in ICU patients. 850 adults on breathing machines for at least 3 days received either the drug or a placebo. The goal was to see if the treatment reduced pneumonia cases by day 28.

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Contacts and locations

Locations

  • Service de Réanimation

    Dijon, 21079, France

  • Service de Réanimation

    Le Mans, 72037, France

  • Service de Réanimation - NHC

    Strasbourg, 67091, France

  • Service de Réanimation Chirurgicale

    Angers, 49933, France

  • Service de Réanimation Médicale

    Orléans, 45100, France

  • Service de Réanimation Médicale

    Poitiers, 86021, France

  • Service de Réanimation Médicale - CH d'Angoulême

    Angoulême, 16959, France

  • Service de Réanimation Médicale - CHD Les Oudairies

    La Roche-sur-Yon, 85025, France

  • Service de Réanimation Médicale - CHU La Milétrie

    Poitiers, 86021, France

  • Service de Réanimation Médicale - CHU Pontchaillou

    Rennes, 35033, France

  • Service de Réanimation Médicale - CHU Rouen

    Rouen, 76031, France

  • Service de Réanimation Médicale - Hôpital Charles Nicolle

    Rouen, 76031, France

  • Service de Réanimation Médicale - Hôpital La Croix-Rousse

    Lyon, 69317, France

  • Service de Réanimation Médicale - Hôpital Louis Mourier

    Colombes, 92700, France

  • Service de Réanimation Médicale - Hôpital Pitié Salpêtrière

    Paris, 75013, France

  • Service de Réanimation Médicale - Hôpital de Hautepierre

    Strasbourg, 67098, France

  • Service de Réanimation Polyvalente

    Argenteuil, France

  • Service de Réanimation médicale, Hôpital Trousseau

    Tours, 37044, France

Conditions

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