Universitätsklinikum Hamburg-eppendorf

This study compares giving norepinephrine continuously versus as needed to prevent low blood pressure during anesthesia in high-risk non-cardiac surgery patients. About 446 adults aged 45 and older with certain risk factors will participate. The goal is to see which method better…

This study is for people with a specific genetic type of multiple myeloma (t(11;14)) that has come back or stopped responding to treatment. It tests a combination of two drugs, belantamab mafodotin and venetoclax, sometimes with a steroid. The goal is to find the safest and most …

This study tests whether raising a natural molecule called beta-hydroxybutyrate (BHB) — through a low-carb diet or a special supplement — can safely make immunotherapy work better for people with multiple myeloma. About 45 participants receiving either CAR-T cells or bispecific a…

This study tests whether having awake ICU patients with severe breathing failure lie on their stomachs (prone position) can reduce the need for a breathing tube or death within 28 days. About 342 participants will be randomly assigned to prone or standard care. The approach is si…

This study looks at whether starting heart rhythm control therapy early after a stroke caused by atrial fibrillation can prevent another stroke, heart-related death, or hospital stays. About 1,746 adults who had a stroke and were recently diagnosed with atrial fibrillation will t…

This study tests whether a brief bout of exercise right before immunotherapy (nivolumab and ipilimumab) is possible for people with advanced melanoma. Researchers want to see if it boosts immune cells that help fight cancer. The trial involves 40 participants and focuses on feasi…

This study tests a new short-term therapy called ORPHYS for people with advanced cancer who feel deep fear, hopelessness, or loneliness. About 160 participants will either receive ORPHYS or standard support. The goal is to see if this therapy reduces emotional distress and improv…

This study tests a new, non-invasive brain stimulation device for people with Parkinson's disease who have moderate to severe hand tremors. The device uses a closed-loop system that detects the person's hand tremor and delivers precisely timed electrical stimulation to the cerebe…

This study is a registry that will track 1000 people with a leaky mitral valve (mitral regurgitation) who are getting a catheter-based valve replacement. The goal is to see how well the procedure works in everyday medical practice and what complications may occur. Participants mu…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study is a registry that collects medical information and biological samples from up to 500 children and adults diagnosed with rare brain tumors like medulloblastoma or ependymoma. It does not test any new treatments. Instead, it aims to gather data from patients treated out…

This study looks at data from about 3 million people across 40 countries to understand how common risk factors like high blood pressure, smoking, and diabetes affect heart disease and death risk. Researchers want to see if these risks differ by geographic region and sex. No new t…

This study tests a new interface that synchronizes two types of brain stimulation—transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS)—in people with Parkinson's disease. The goal is to see if the interface can precisely time the stimulations and m…

This study is testing a new online learning tool designed to help people with cancer improve their ability to find and understand health information on the internet. About 660 cancer patients will take part, and they will be randomly assigned to use the online tool, read a PDF wi…

This study looks at how a stroke can disrupt the body's automatic functions like heart rate and blood pressure. Researchers will use brain scans, blood tests, and heart monitoring in 100 people who recently had a stroke or a mini-stroke. The goal is to better understand these cha…

This study looks at 264 adults recovering from non-cardiac surgery to see if wearing a continuous vital sign monitor (instead of nurses checking vitals at set times) reduces the time spent with dangerous vital signs. Participants are 45 or older and will be monitored for the firs…

This study follows 1,000 hospitalized adults with acute kidney injury to understand how kidneys recover and what long-term problems may arise, such as chronic kidney disease, heart issues, or dementia. Researchers will compare patients with kidney injury to those without to ident…