Sheba Medical Center

This study follows 120 Israeli children and teens with type 1 diabetes who use the Medtronic 780G system, a closed-loop insulin pump that automatically adjusts insulin. Researchers will track blood sugar control, sleep, diet, and emotional well-being over two years. The goal is t…

This study tests a new treatment called SHB-04-CD22, which uses a patient's own immune cells (T-cells) engineered to find and attack cancer cells that have a protein called CD22. It is for children and adults (ages 1-80) with B-cell cancers that have come back or not responded to…

This study tests whether adding azithromycin to the standard antibiotic ampicillin can reduce serious health problems in newborns when a mother's water breaks early (between 34 and 37 weeks). About 311 women with a single pregnancy will receive either ampicillin alone or ampicill…

This study is testing whether a portable virtual reality headset can help diagnose and monitor traumatic brain injury (TBI) by measuring how the pupils react to light. Researchers will compare pupil responses in 150 people: those with mild to moderate TBI, those with other injuri…

This study tests if carbetocin, a drug that helps the uterus contract, works better than standard oxytocin to prevent heavy bleeding after twin deliveries. Heavy bleeding is more common with twins and can cause serious health problems. About 120 pregnant people with twins will be…

This study tests whether group-based MDMA-assisted therapy works as well as individual sessions for people with PTSD linked to the October 7, 2023 events. 168 participants will receive MDMA in either a group or individual setting, along with therapy sessions. The goal is to see i…

This study looks at whether testing lung cancer cells in a lab can predict which drugs will work best for each patient. Researchers will collect fluid from around the lungs of 400 people with lung cancer who need drainage for shortness of breath. They will grow the cancer cells i…

This study is testing whether a personalized health and behavior program can slow or reverse biological aging in healthy adults over 50. Researchers will measure aging using DNA and blood tests. About 1,500 participants will be randomly assigned to either receive the personalized…

This study looks at how different arm positions change blood pressure readings in pregnant women. About 300 pregnant women will have their blood pressure taken with their arm in three positions: supported at heart level, on the lap, and hanging at the side. The goal is to find ou…

This observational study looks at saliva thickness and oral health in people with Oculopharyngeal Muscular Dystrophy (OPMD) compared to their household members. Researchers want to see if swallowing problems affect oral health and if saliva contains markers of the disease. No tre…

This study explores whether temporarily opening the blood-brain barrier using a special electrical field during spine surgery can release brain-specific markers into the blood. Researchers will compare these blood markers to those found in spinal fluid from the same patient. If i…

This study is testing a new, noninvasive eye test called chromatic multifocal pupillometry to see if it can detect vision problems in people with pseudotumor cerebri (PTC), a condition where increased pressure in the skull can damage the optic nerve and cause vision loss. Researc…

This study looks at how laser light bounces off different parts of the eye, like the cornea and retina. Researchers will measure the reflected light at various angles and colors in 20 healthy volunteers aged 18-40. The goal is to make laser-based eye exams and surgeries safer and…