Blood test breakthrough? opening the Brain's barrier during surgery may reveal hidden clues

NCT ID NCT07224451

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether temporarily opening the blood-brain barrier using a special electrical field during spine surgery can release brain-specific markers into the blood. Researchers will compare these blood markers to those found in spinal fluid from the same patient. If it works, it could pave the way for a simple blood test to diagnose brain and spinal cord diseases without a spinal tap.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Barrier disrupting fields (BDF) procedure

What this could lead to

If successful, this could lead to a less invasive way to detect brain and spinal cord conditions using a simple blood test instead of a spinal tap.

What could go wrong

This is a very early feasibility study with only 20 participants. The procedure is done under anesthesia during surgery, so results may not apply to awake patients or other settings.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

intradural extramedullary spinal canal neoplasm spinal cord neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, 52621, Israel

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact