Seattle Children's Hospital

This early-stage trial tests a new treatment for children and young adults (ages 2-30) with severe lupus that hasn't responded to standard therapies. The treatment involves collecting a patient's own immune cells, engineering them to target and destroy faulty B cells (which drive…

This study looks at whether feeding babies with certain intestinal conditions (like gastroschisis or Hirschsprung disease) only human milk helps them reach full feeding volumes faster compared to standard feeding with formula. Researchers will also check if it reduces infections …

This early-phase study tests whether a new type of immune cell therapy, called CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with certain aggressive brain tumors. The therapy uses the patient's own immune cells, which are mo…

This early-phase study tests a new type of immunotherapy for children and young adults with certain solid tumors that have come back or not responded to treatment. The therapy uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer c…

This early-stage study tests a new treatment called SC-DARIC33 for children and young adults up to age 30 whose acute myeloid leukemia (AML) has returned or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in the lab to bett…

This study tests an internet-based program for parents with irritable bowel syndrome (IBS) to help them encourage healthy habits in their young children. About 460 parent-child pairs will take online surveys and use one of two websites chosen at random. The goal is to see if teac…

This study compares two non-drug treatments for teens aged 13-17 with ADHD: Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI). Both involve eight 90-minute sessions. Researchers will measure changes in ADHD symptoms, daily functioning, and emotional co…

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis who suffer from severe abdominal pain. The program uses psychological techniques to help reduce pain's impact on daily life and improve quality of life. Researchers aim to enr…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study looks at two different approaches to help doctors prescribe follow-up visits only when needed for children hospitalized with bronchiolitis. The goal is to reduce unnecessary visits that families often find burdensome. Researchers will compare a moderate-resource strate…

This study looks at how to best help teens aged 11-17 who have been hospitalized for suicidal thoughts or actions. Researchers will compare different treatments to see which ones work best to prevent future suicide attempts and reduce suicidal thinking. The goal is to find simple…

This study tests a communication tool that uses photos and stories to help parents of children with severe brain conditions share what matters most with their ICU doctors. About 160 parents and children will take part to see if the tool is easy to use and reduces stress. The goal…

This study tests a program to help Hispanic children (ages 3-17) with traumatic brain injury and their families. The program provides in-person education, videos, and a navigator to help with follow-up care. The goal is to see if this support helps children attend rehab appointme…

This study compares a redesigned well-child care model, where a community health worker acts as a parent coach, to standard checkups for Black families with young children. The goal is to see if the new model helps families get more recommended preventive services, reduces emerge…

This study aims to collect blood, stool, and tissue samples from 200 children with inflammatory bowel disease (like Crohn's or colitis) and children with other gut issues but no inflammation. Researchers will use advanced technology to study the genes and cells in these samples. …

This study tests a new tool called the Family Media Check-In that helps parents and teens work together to create a family media plan. About 300 parent-teen pairs will try it and report how satisfied they are with the plan and how much conflict it reduces. The goal is to see if s…