Seattle Children's Hospital

This early-phase study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The therapy a…

This early-stage study tests a new treatment for children and young adults with relapsed B-cell leukemia. The approach uses a patient's own immune cells, modified to recognize and attack leukemia cells. The main goals are to check safety and find the best dose, with a secondary l…

This early-stage study tests a two-part treatment for osteosarcoma that has returned or not responded to standard therapy. First, a patient's own immune cells are collected and genetically modified to become CAR T cells that can recognize a special marker. Then, a compound called…

This early-phase study tests a new treatment for children and young adults with neuroblastoma that has come back or not responded to standard therapy. The treatment uses the patient's own immune cells (T-cells) that are modified in a lab to recognize and attack cancer cells. The …

This study looks at whether adding a weekly medicine (exenatide) to family-based behavioral therapy helps children ages 10-12 with obesity lose more weight. About 63 children will take part, and researchers will track changes in body mass index and body composition. The goal is t…

This early-phase study tests a new type of immunotherapy for children and young adults with leukemia that has come back or not responded to treatment. The therapy uses the patient's own immune cells, modified to recognize two different targets (CD19 and CD22) on leukemia cells, t…

This early-stage study tests a new treatment for children and young adults with certain aggressive brain tumors, including DIPG and DMG. The therapy uses the patient's own immune cells, modified in a lab to target four different markers on tumor cells, and delivers them directly …

This study tests a new treatment for children and young adults up to age 30 whose leukemia or lymphoma has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells that carr…

This study tests a new approach to help children and young adults with a type of leukemia (CD19+ acute leukemia) that has come back or not responded to treatment. After patients receive CAR T cell therapy, their cancer-fighting cells can fade over time, allowing the leukemia to r…

This early-phase study tests a personalized cell therapy for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, modified to recognize and attack a protein called B…

This early-phase study tests a personalized cell therapy for children and young adults (ages 1–30) with solid tumors that have returned or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to recognize and attack cancer cells carrying…

This study aimed to see if a telehealth skills group could help middle and high school students with ADHD improve their organization, motivation, and grades. Both the treatment and control groups were delivered via Zoom. However, the study was withdrawn before enrolling any parti…

This study looks at whether using mobile video interpretation can help doctors and patients who speak different languages communicate better. Over 6,600 patients and their doctors at Seattle Children's Hospital will take part. The goal is to see if this approach makes care safer …

This study tests a program called the Family Bridge Program (FBP) designed to help low-income families better navigate hospital care and communicate with doctors. About 728 families with children in the hospital will be randomly assigned to receive the program or standard care. T…