Northwestern University

This study is for people with liver cancer whose liver is too small for surgery. Doctors use a special radiation treatment (Y90) to help the healthy part of the liver grow larger. Once it's big enough, patients can have surgery to remove the cancer. The study compares standard ca…

This study is for people with a common type of advanced breast cancer (ER+/HER2-) that has stopped responding to a prior CDK4/6 inhibitor. It compares taking elacestrant alone versus elacestrant combined with another targeted drug (palbociclib, abemaciclib, or ribociclib). The go…

This study is testing whether giving fresh frozen plasma (FFP) to people with moderate to severe traumatic brain injury is safe and helps them recover. About 357 adults aged 18 to 65 will be randomly assigned to receive either standard care alone or standard care plus two units o…

This study tests whether artificial intelligence (AI) can help doctors choose the right radiation dose for each person with lung cancer. About 70 participants will receive a precise type of radiation called SBRT, with the dose guided by an AI tool. The goal is to see if this pers…

This study tests whether a special vacuum system that cleans and closes wounds can help heal chronic pressure sores better than standard bandage changes. About 62 adults with stage 3 or 4 pressure sores on the tailbone or hip area will take part. The goal is to see if the vacuum …

This study tests two programs to help young people aged 15-24 in Nigeria. One program helps find youth who have HIV and get them into care. The other helps those already diagnosed stick with treatment and lower their virus levels. Both use mobile health tools and peer support. Th…

This study aims to help control high blood pressure in Chicago's South Side, where rates are high and resources are low. About 2,000 adults from local churches and clinics will take part in a program led by community health workers. The program uses proven methods like simplified…

This study tests a drug called Ublituximab (Briumvi) in 40 adults with early relapsing multiple sclerosis (MS). The goal is to see if the drug is safe and can reduce nerve damage markers in the blood over about a year. Participants receive the drug twice a year, and researchers t…

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started Parkinson's medication will be assigned to either moderate or high-intensity treadmill wor…

This study tests if breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can improve symptoms and reduce the need for stronger medications or…

This study tests a wearable device called a myoelectric-computer interface (MCI) that helps stroke survivors improve arm movement. The device gives feedback on muscle activity to reduce abnormal co-contraction that limits coordination. The study will enroll 96 people who had a st…

This study tests whether shining a special red light on the legs every day before a walking session can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to poor blood flow. The study will compare real light treatment to…

This study tests whether having a physical therapist in the emergency department can help people with low back pain get faster care. About 140 adults with recent back pain will either get usual care or see a PT right in the ER. The goal is to see if this approach is practical and…

This study is testing two different parent-led therapies for young children with autism, ages 18 to 48 months. The goal is to find the best order to give these therapies to improve the child's social communication and reduce disruptive behaviors. Researchers will also look at wha…

This study looks at whether over-the-counter hearing aids can improve communication for people over 60 with mild hearing loss and mild cognitive impairment or early Alzheimer's. Participants and a partner will try either hearing aids first or communication tips first. The goal is…

This study uses advanced MRI scans to watch how the brain and spinal cord work together during arm movements in people who have had a stroke. Researchers want to understand which nerve pathways the brain uses to move the shoulder after a stroke. The goal is to learn more about ho…

This study looks at how dapagliflozin, a drug used for diabetes, affects the heart and metabolism in people with chronic kidney disease. Researchers will measure heart function and blood markers in 60 adults. The goal is to understand how the drug works, not to test a cure.

This study looks at how a brain chemical called noradrenaline relates to sleep and thinking skills in older adults with insomnia. Researchers will measure this chemical in the blood and use a light therapy to see if it improves sleep and memory. The goal is to understand why peop…

This study enrolls 222 men with low-risk prostate cancer to see if using MRI and a genetic test (Genomic Prostate Score) helps them stick with active surveillance (monitoring instead of immediate treatment). Researchers will compare how well these men follow monitoring schedules …

This study tests whether text message reminders can encourage more teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex and are HIV-negative or unsure of their status will receive either helpful texts or general health information. Researchers will then …

This study tests whether a digital cognitive test can help primary care doctors detect early memory problems and dementia in underserved communities. About 45,000 adults aged 65 and older without prior diagnosis will participate across 24 clinics. The goal is to improve early det…

This study collects tumor tissue from up to 10,000 women undergoing breast cancer surgery. The samples are stored and used for future research to better understand breast cancer. No treatment or direct benefit is offered to participants.