National Heart, Lung, And Blood Institute (nhlbi)

This study is testing a new combination of drugs designed to make a curative stem cell transplant safer, especially for sickle cell patients who already have damage to organs like their heart, lungs, or kidneys. The goal is to help the patient's body accept donor cells without se…

This study is testing if adding a new antibody drug called briquilimab (JSP191) to a blood stem cell transplant makes the treatment more successful for people with sickle cell disease or beta-thalassemia. The transplant is a potential cure, and researchers want to see if the drug…

This was a follow-up study for people who had a stem cell transplant and then developed low blood cell counts (cytopenias). It aimed to see if taking the drug fostamatinib long-term (up to 21 more months) could safely help them maintain healthier levels of red blood cells or plat…

This study tests whether switching patients from cyclosporine to sirolimus helps prevent severe aplastic anemia from returning. Participants who responded well to previous immune-suppressing treatment will either switch to sirolimus or stop medication entirely, with close monitor…

This study is testing the long-term safety and effects of a drug called mitapivat for adults with stable sickle cell disease. It is an extension for 15 people who benefited from an earlier short-term study. Participants will take the pill twice daily for up to two years while res…

This study is testing if special, low-energy MRI settings can safely allow doctors to use standard guidewires during a heart catheterization procedure. Guidewires help steer the catheter but are usually unsafe in an MRI because they can heat up. Researchers want to see if this ne…

This study aims to understand how the drug mitapivat works in people with sickle cell disease. It involves only 6 participants who are already in a larger trial testing the drug's effectiveness. Researchers will take extra blood samples and use a non-invasive skin test to measure…

This study aims to collect medical information from up to 10,000 patients and stem cell donors to help researchers learn more about a wide range of diseases and train future doctors. Participants' existing medical records, test results, and treatment data will be gathered over tw…

This long-term study followed nearly 5,900 adults aged 65 and older to identify what factors predict heart disease and stroke in the elderly. Researchers tracked participants' health over decades, using exams and tests to understand how risk factors like high blood pressure and c…

Researchers are testing a new heart monitoring system called EDEN during heart procedures. The system records and analyzes electrical signals from the heart but doesn't affect patient care or treatment decisions. The study involves 50 adults who are already scheduled for heart pr…

This is a screening study to see if people are healthy enough or have the right condition to join other research studies. It involves up to 10,000 people, including patients, donors, and healthy volunteers. The goal is to run tests and exams to determine who can safely participat…

This study aims to learn how a new immunotherapy drug called epcoritamab works against two types of blood cancer. Researchers will analyze small tissue samples from five invited patients before and during their treatment. The goal is to see how the drug affects cancer cells and t…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aims to better understand heart failure by collecting blood samples and health data from 2000 adults who already have the condition. Researchers will analyze the samples to look for proteins and other biological markers that might explain why heart function declines ov…

This study aims to understand the genetic and molecular changes that cause bone marrow failure diseases, where the body stops making enough blood cells. Researchers will analyze blood and bone marrow samples from about 1,400 patients with these conditions to see how specific gene…

This study is collecting blood and urine samples from adults with and without sickle cell disease to help researchers develop better laboratory tests. The samples will be used to study how inflammation and blood vessel function relate to sickle cell disease and other conditions. …