National Heart, Lung, And Blood Institute (nhlbi)

This study tests whether adding a new antibody drug (briquilimab, JSP191) to a standard stem cell transplant can help more people with sickle cell disease or beta-thalassemia achieve a full donor blood system, potentially curing their condition. About 40 participants aged 13 and …

This early-phase study tests a new gene therapy for people with advanced clear cell kidney cancer. Doctors take a patient's own white blood cells, modify them in the lab to better recognize and attack cancer cells, and then return them to the patient. The main goals are to check …

This study tested a combination of two drugs, ibrutinib and fludarabine, in 29 people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. Participants took ibrutinib daily and received fludarabine for a short time. The goal was to see how many patients achi…

This study tests a new method called VINTAGE to treat ventricular arrhythmia, a condition where the heart beats abnormally. It is for people whose arrhythmia did not improve with standard treatments. Doctors will use special catheters to reach and destroy hard-to-access parts of …

This study tests whether the drug sirolimus can prevent severe aplastic anemia from coming back after patients stop taking cyclosporine. About 84 people aged 2 and older who have responded to initial treatment will take sirolimus for 3 months or be monitored without it. The goal …

This study tests a new combination of drugs and low-dose radiation to make stem cell transplants safer for people with sickle cell disease, including those with organ damage. Six participants aged 16 and older will receive a transplant from a family donor. The goal is to see if t…

This study tests a daily pill called PCI-32765 for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are over 65 or have a specific genetic change (17p deletion). These groups often don't respond well to standard chemotherapy. The goal is to s…

This study looks at the long-term safety and tolerability of the drug mitapivat in adults with stable sickle cell disease. Participants, who must have benefited from mitapivat in a prior study, will take the drug twice daily for up to 48 weeks, with an option to continue for anot…

This study was designed to give people who responded well to fostamatinib in an earlier trial continued access to the drug for up to 21 months. The goal was to keep blood cell levels stable after a stem cell transplant. However, the study was withdrawn before enrolling any partic…

This study tests a stem cell transplant from a half-matched family donor for adults with severe sickle cell disease or beta-thalassemia. Instead of high-dose chemotherapy, it uses low-dose radiation and immune-suppressing drugs to prepare the body. The goal is to see if this gent…

This study tests a new stem cell transplant method for adults with severe sickle cell disease. Participants receive stem cells from a half-matched relative after low-dose radiation and immune-suppressing drugs. The goal is to see if the transplant can control the disease without …

This study tests a new procedure called TRAIPTA for people with a leaky tricuspid heart valve who cannot have standard surgery. The device works like a belt around the heart to reduce the leak. Researchers want to see if it is safe and helps improve symptoms like shortness of bre…

This study tests whether adding eltrombopag to standard immune-suppressing drugs can help people with severe aplastic anemia, a rare condition where the immune system attacks the bone marrow. About 207 untreated patients aged 2 and older will receive the combination and be monito…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers measured known risks like high blood pressure and diabetes to see how they affect older people's health over time. The goal was to …

This study tests a new device called the EDEN system that records and analyzes electrical signals from the heart during medical procedures. About 50 adults having heart procedures will use the EDEN system alongside standard equipment. The goal is to see if the system can correctl…

This study screens up to 10,000 people with blood disorders or healthy volunteers to see if they can safely join other NHLBI research studies at the NIH. Participants undergo tests like blood work and imaging. If eligible, they may be offered a spot in an active study; if not, th…

This study tests whether special low-energy MRI settings can make it safe to use standard guidewires during heart catheterization. Guidewires help position catheters but can heat up in an MRI machine. Researchers will enroll 22 adults who need a right heart catheterization to see…

This study aims to collect blood, urine, and stool samples from 2000 adults with heart failure to better understand how the disease progresses. Researchers will analyze these samples to find proteins and other factors linked to worsening heart function. Participants have one visi…

This study gathers medical records, test results, and treatment information from up to 10,000 people with various blood and heart conditions, as well as stem cell donors. The goal is to create a large database that researchers can use to develop new ideas for future studies. Part…

This study collects blood and other samples from 2,000 adults with sickle cell disease and healthy volunteers. Researchers will use the samples to study how blood vessels work and what goes wrong in diseases like sickle cell. The goal is to better understand these conditions, not…

This study looks at blood, bone marrow, and lymph node samples from people with chronic lymphocytic leukemia (CLL) or Richter syndrome who are already receiving epcoritamab in another trial. The goal is to learn how the drug changes immune cells and cancer cells over time. Only 5…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study aims to better understand bone marrow failure disorders by analyzing genetic and protein changes in blood and bone marrow samples from up to 1,400 participants aged 2 and older, including healthy volunteers. Researchers hope to learn how these changes affect disease pr…

This observational study looks at how the drug mitapivat changes red blood cells in people with sickle cell disease. Researchers will measure how well the cells carry oxygen and how long they survive. The study involves about 6 people already enrolled in a larger trial, with extr…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…