New stem cell transplant could help sickle cell patients without a perfect donor match

This study tests a stem cell transplant using cells from a half-matched family donor, combined with low-dose radiation and drugs to prevent rejection, for adults with severe sickle cell disease or beta-thalassemia. The goal is to see if this gentler approach can replace the diseased cells without the high toxicity of standard chemotherapy. Twenty-three participants will be followed for five years to check if the donor cells survive and reduce disease symptoms.