New antibody may boost stem cell transplant success for blood disorders
NCT ID NCT05357482
First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 29 times
Summary
This study tests whether adding an antibody drug (JSP191) to a stem cell transplant can help more people with sickle cell disease or beta-thalassemia achieve a full donor blood system. About 40 participants aged 13 and older will receive the transplant and stay in the hospital for about 30 days, then remain near the clinic for 3 months. The goal is to see if this approach increases the percentage of donor cells in the blood one year after transplant, potentially reducing disease complications.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Conditions
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