Scientists dive deep into Epcoritamab's effects on Hard-to-Treat blood cancers

NCT ID NCT06676033

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at blood, lymph node, and bone marrow samples from 5 people with chronic lymphocytic leukemia or Richter syndrome who are receiving the drug epcoritamab. Researchers want to understand how the drug changes immune cells and tumor cells over time. The goal is to learn more about how this type of immunotherapy works, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

epcoritamab

What this could lead to

If successful, this study could reveal how epcoritamab attacks cancer cells, helping to improve future treatments for CLL and Richter syndrome.

What could go wrong

This is a very small, early-phase study with only 5 participants, focused on lab analysis rather than direct treatment outcomes. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States