New drug duo shows promise for Tough-to-Treat blood cancers

NCT ID NCT03534323

Ongoing Disease control Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a combination of two drugs, duvelisib and venetoclax, in 55 people with relapsed or refractory chronic lymphocytic leukemia (CLL) or Richter's syndrome. Duvelisib blocks a protein that helps cancer cells survive, while venetoclax targets another survival protein. The goal is to see how many patients achieve complete remission. The trial is active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: duvelisib and venetoclax
What this could lead to: If successful, this combination could offer a new treatment option for people with hard-to-treat CLL or Richter's syndrome.
What could go wrong: This is an early-phase trial with only 55 participants, so results may not apply to everyone. The drugs can cause side effects like infections or low blood counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA RICHTER SYNDROME

Contacts and locations

Locations

Berkshire Medical Center

Pittsfield, Massachusetts, 01201, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Northern Light Eastern Maine Medical Center

Brewer, Maine, 04412, United States
University of Miami- Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States

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