Monash University

This study is testing whether giving patients 30%, 50%, or 80% oxygen during and right after major surgery can reduce wound infections and other complications. About 7,800 adults having surgery lasting at least 2 hours will take part. The goal is to find the best oxygen level to …

This study compares giving antibiotics only during heart surgery versus continuing for 24 or 48 hours afterward, to see if shorter use is just as good at preventing surgical site infections. Over 9,000 adults having heart surgery through a breastbone incision will take part. The …

This study compares immunoglobulin (given through a vein or under the skin) with antibiotics to see which better prevents severe infections in people with blood cancers like myeloma, lymphoma, or leukemia who have low antibody levels. About 900 adults will take part. The goal is …

This study compares two infection-prevention strategies in 900 people with blood cancers like myeloma and leukemia. One group gets an antibiotic (co-trimoxazole) daily, while another receives immunoglobulin infusions every few weeks. The goal is to see which approach better preve…

This study compares different ways to prevent infections in people with blood cancers like myeloma, leukemia, and lymphoma. About 900 participants will receive either daily antibiotics or immunoglobulin therapy, or a combination. The goal is to see which approach works best to ke…

This study looks at different ways to prevent serious infections in people with blood cancers like myeloma, lymphoma, and leukemia. About 900 participants will receive either antibiotics or immunoglobulin therapy to see which approach works best. The goal is to find safer and mor…

This large phase 3 trial is testing whether giving lidocaine (a numbing medicine) during and after breast cancer surgery can reduce the chance of long-term pain. About 4,300 women having mastectomy or breast-conserving surgery will receive either lidocaine or a placebo. The main …

This study aims to understand how syphilis bacteria spread from people without visible symptoms, focusing on women and men who have sex with women only—groups often overlooked in past research. Researchers will collect swabs and blood samples from 480 participants with early syph…