Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This study tests a non-invasive procedure called focused ultrasound for adults with limb dystonia that hasn't improved with medication or Botox. The treatment uses sound waves to create a tiny lesion in a brain area that controls movement. Researchers will compare real treatment …

This study looks at better ways to diagnose and treat people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. About 337 adults will be followed to see how well surgical removal of the seizure focus, or …

This study tests a type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic face pain that has no clear physical cause. The goal is to see if changing how the brain processes pain can lower pain intensity and improve quality of life. Sixty adults will b…

This study compares Botox injections guided by ultrasound versus standard injections (using body landmarks) in 100 adults with cervical dystonia, a condition causing painful neck muscle spasms. Participants will receive both types of injections at different times and complete que…

This study tests whether using lower doses of anesthesia during brain tumor surgery helps patients wake up more quickly and safely. Researchers will monitor 100 adults undergoing elective neurosurgery. The goal is to improve recovery right after surgery without causing discomfort…

This study explores whether a daily postbiotic supplement (PostbiotiX Comfort®) can improve gut and behavioral symptoms in 90 children aged 3-8 with autism. Researchers will check changes in stomach issues, sleep, and behavior after one month of treatment. The goal is to find a n…

This study looks at how cholesterol and its byproducts relate to different types of dementia, like Alzheimer's and frontotemporal dementia. Researchers will measure these substances in brain tissue, spinal fluid, and blood from 80 adults aged 40-85. The goal is to understand if c…

This study listens to patients with a slow-growing brain tumor (IDH-mutant grade 2 glioma) to understand how they feel during treatment. It compares two approaches: radiotherapy and a drug called vorasidenib, plus a group just being watched. The goal is to learn which treatment b…

This study is testing a smartphone app that creates a "digital twin" of the patient to help manage health after a stroke or related conditions like moyamoya disease or cerebral amyloid angiopathy. About 20 adults will use the app daily alongside standard care, while another group…

This study looks at epigenetic changes in meningioma, the most common brain tumor, to find markers that might predict if the tumor will come back after surgery. Researchers will analyze tissue and blood samples from 210 adults who had their tumor fully removed. The goal is to imp…

This study collects blood and tissue samples from 400 people with brain aneurysms (some ruptured, some not) and 200 healthy volunteers. Researchers will analyze the participants' genes to find variations linked to a higher risk of aneurysm rupture. The goal is to create a tool th…

This study aims to find biological markers (biosignatures) for ALS and FTD, two related brain diseases that are currently hard to diagnose. Researchers will analyze samples like spinal fluid, skin, and tears from 230 adults using advanced techniques. The goal is to create a 'dise…

This study looks at how well two computer models predict the effects of propofol and remifentanil in brain surgery patients after they are moved to the intensive care unit. Researchers will compare the models' accuracy during ICU care versus during surgery. The goal is to improve…

This study collects skin cells from 100 children with autism (ages 3-15) to create stem cells in a lab. Researchers will study how these cells behave and compare them to cells from children without autism. The goal is to better understand what causes autism and find new ways to t…

This study aims to find early biological markers for Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will combine these results with brain scans and clinical exams to build a model that helps d…

This study looks at the mental health, emotions, and quality of life of 180 adults with drug-resistant focal epilepsy who are eligible for epilepsy surgery. Researchers will track changes in these areas before and after surgery to better understand how patients feel and cope. The…

This study explores whether ultrasound, a low-cost and widely available tool, can help doctors better understand and treat patients with disorders of consciousness (DOC), such as coma or a minimally conscious state. Researchers will use brain ultrasound to measure brain activity …

This study looks at how a type of brain tumor (parietal lobe glioma) affects a person's ability to pay attention to one side of space. Researchers will test 40 adults before and after surgery to see how these attention problems change over time. The goal is to better understand t…

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will test the translated version with 190 Italian-speaking patients to make sure it works correctly. The goal is to give doctors a reliab…

This study is testing a new fiber optic system that fits inside a standard biopsy needle to help doctors see tumor tissue and avoid blood vessels during brain tumor biopsies. The system uses special light and ultrasound to give real-time feedback. Researchers will test it on 20 b…

This study is testing whether a dye called 5-ALA, which makes brain tumor cells glow during surgery, can also help detect tumor signals in the blood and urine. Researchers will take samples from 30 adults with glioblastoma or other brain tumors before and after the dye is given. …

This study aims to find new biomarkers for Amyotrophic Lateral Sclerosis (ALS) by analyzing nerve biopsies from 400 patients and mouse models. Researchers will look at single cells to identify molecular changes that happen early in the disease. The goal is to develop better diagn…

This study aims to understand how migraine affects thinking skills like memory and attention, and how it relates to mood, worry, and coping. Researchers will test 150 adults with migraine using cognitive assessments and questionnaires. The goal is to better characterize the migra…

This study is collecting information from 500 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain and memory problems in older adults. Researchers aim to better understand how the disease progresses and find markers that could improve diag…

This study follows 1,000 people of all ages who are having a minimally invasive procedure (endovascular treatment) for brain or spine blood vessel problems like aneurysms or AVMs. Researchers will track complications, recovery, and changes in thinking, mood, and quality of life f…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with dystonia, a movement disorder. Researchers will use brain scans and electrical recordings from the implanted device to see how brain activity changes over time. The goal is to better unders…

This study looks at how nerves work in people with Charcot-Marie-Tooth disease and other nerve disorders like CIDP. Researchers will use special electrical tests and ultrasound to measure nerve signals and structure. The goal is to better understand these conditions, not to test …

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study watches 300 adults after brain surgery to see if heart rate patterns and brain wave activity can predict complications. Researchers will monitor patients in the recovery room for up to two hours. The goal is to find better ways to detect problems early and personalize …

This study tests whether injecting a fluorescent dye called sodium fluorescein during brain tumor surgery helps surgeons see and remove more of the tumor. About 800 people with suspected aggressive brain or spinal cord tumors will receive the dye before surgery. The goal is to se…

This study aims to standardize care for people with rare brain tumors by using artificial intelligence to analyze patient data and predict recovery after surgery. Researchers will collect information on symptoms, brain scans, and cognitive function from 200 adults undergoing surg…

This study follows 50 children with PTEN gene changes to learn how often they develop tumors. Participants get yearly check-ups including blood tests, ultrasounds, and skin exams for 5 years. The goal is to create better monitoring guidelines and compare risks with affected adult…