Beijing Anzhen Hospital

This study tests whether using a wearable device (like a smartwatch) to monitor patients remotely can help doctors adjust heart failure medications more effectively. It includes 400 adults with both heart failure and atrial fibrillation. The goal is to improve treatment and reduc…

This study tests a drug called all-trans retinoic acid (ATRA) as a first treatment for hemophagocytic lymphohistiocytosis (HLH), a rare but life-threatening condition where the immune system goes into overdrive. ATRA is an oral medication already used for other blood diseases and…

This study will enroll 30,000 adults in China with atrial fibrillation (a type of irregular heartbeat) that hasn't improved with medication. They will receive a new type of catheter treatment called pulse-field ablation. Researchers will track their health for up to 10 years to s…

This study compares two cholesterol-lowering strategies in 6,000 Chinese patients with very high-risk heart disease. One group aims for ultra-low LDL cholesterol below 1.0 mmol/L, while the other targets a moderate level of 1.0-1.39 mmol/L. Researchers will track heart attacks, s…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This study tests whether a drug called a PCSK9 inhibitor (Tafolecimab) can slow the progression of mild to moderate calcific aortic stenosis, a condition where the heart valve narrows and hardens. Researchers will give the drug to half of 160 participants and compare changes in v…

This study will test two ways of controlling blood sugar during heart surgery in 3000 elderly patients with type 2 diabetes. One group will have tight control (blood sugar between 5-8 mmol/L) and the other liberal control (11-14 mmol/L). The goal is to see which approach leads to…

This trial tests a procedure called TEER, which uses a clip to repair a leaky heart valve (mitral regurgitation) caused by an irregular heartbeat (atrial fibrillation). The study will include 400 people with moderate-to-severe or severe leakage who still have symptoms despite tak…

This study tests a new type of catheter (a thin tube) designed to make carotid artery stenting easier and safer when done through the wrist. About 204 people with blocked neck arteries will be randomly assigned to get the new catheter or a standard one. The main goal is to see if…

This study tests whether a smartphone app that helps manage blood pressure, cholesterol, and blood sugar can lower heart disease risk better than standard care. About 790 adults at high risk for heart disease will use the app for one year, with doctors reviewing its suggestions. …

This study tests whether a smartphone app can help people with coronary heart disease better manage their blood pressure and cholesterol after having a stent placed. About 792 participants will either use the app for one year or receive usual care. The app reminds patients to che…

This study compares catheter ablation (a procedure to fix irregular heartbeats) with standard medical care in 646 adults who have both atrial fibrillation and a recent brain bleed. The goal is to see if ablation reduces the risk of death, stroke, or blood clots. Participants must…

This study tests a device called CA330 that filters blood during heart surgery to reduce severe bleeding. It includes 120 adults on blood thinners who need non-elective heart surgery. Participants are randomly assigned to receive either the filter plus standard care or standard c…

This study tests if gently cooling the body (to 33-34°C) during emergency heart procedures can limit heart damage in people having a severe heart attack complicated by shock. All 44 participants will receive standard care with a heart-lung machine, and half will also be cooled fo…

This study will test whether a small, wearable patch that records heart activity for 7 days can find undiagnosed atrial fibrillation (a common heart rhythm problem) in 30,000 Chinese adults aged 60 and older. Participants will wear the patch and then be followed for up to 10 year…

This study is testing a new, non-invasive way to screen for high cholesterol using a person's breath. Researchers will collect exhaled breath samples from 280 healthy adults and those with high cholesterol. They will analyze the breath for unique chemical patterns to see if the t…

This study aims to create a risk prediction model for acute myocardial infarction (heart attack) using artificial intelligence and wearable devices. Researchers will enroll 3,000 high-risk patients in the Beijing area and collect data from ECGs and other sources. The goal is to e…

This study is testing a new tool called UFR, which uses ultrasound images to measure blockages in heart arteries during a heart attack. Currently, the most accurate method requires patients to return 30 days later for a second invasive procedure. The study will enroll 200 heart a…

This study looks at whether new blood markers (TAT, PIC, TM, t-PAIC) can help diagnose and monitor acute pulmonary embolism (a dangerous blood clot in the lungs). Researchers will test 200 newly diagnosed patients and 200 healthy controls to see how accurate these markers are. Th…

This study tests whether taking a low dose of colchicine (0.5 mg) every day for two years after coronary artery bypass grafting (CABG) can prevent the new blood vessel grafts from failing. About 622 adults who just had bypass surgery will be randomly assigned to get either colchi…

This study looks at 224 adults with a type of irregular heartbeat called paroxysmal atrial fibrillation who are getting a first-time heart procedure called pulsed-field ablation. Researchers want to see if using conscious sedation (being awake but relaxed) is safer than general a…

This observational study will follow 2,352 adults with coronary heart disease to see how factors like blood sugar, sleep, and heart imaging relate to thinking and memory problems. Participants will take memory tests and undergo scans and blood work during a hospital stay. The goa…

This study will follow 600 adults having off-pump heart bypass surgery to see how often memory and thinking problems occur afterward. Participants take a simple thinking test before and after surgery. The goal is to understand what factors might increase the risk of these problem…

This study will enroll 1000 heart failure patients to see if different types of body fat—around the heart, under the skin, and within muscles—are linked to heart structure and future health events like heart attacks or strokes. Researchers will use CT scans to measure these fat d…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study will follow 1,800 people who had a stent placed in their heart arteries using a special camera (OCT). Researchers want to see if new measurements from routine angiograms can better predict future heart problems like heart attacks or chest pain. The goal is to improve h…

This study looks at 212 heart disease patients who take antiplatelet drugs and have sudden upper stomach bleeding. It compares having an endoscopy within 12 hours versus waiting 12-24 hours to see which timing is safer and more effective. The goal is to find the best approach to …

This study will enroll 1,000 patients in China who have a heart attack complicated by cardiogenic shock, a life-threatening condition. Researchers will test a new team-based care system and create a risk model tailored to Chinese patients. The goal is to reduce deaths and improve…

This study will follow 11,100 adults with sleep-disordered breathing for up to 5 years. Researchers will collect health data and samples to find better ways to predict risks and tailor treatments. No new drug or device is being tested; participants receive standard care like CPAP…

This study will use data from over 10,000 people to create a risk prediction model for coronary artery disease. Researchers will combine heart imaging scans (like CT angiograms) with blood markers (like cholesterol) to better identify who is at high risk for heart attacks or othe…

This study looks at 1,200 adults after heart surgery to see if large swings in blood pressure and poor blood flow to tissues are linked to serious problems like stroke, heart attack, or kidney failure. Researchers will monitor patients in the ICU for at least 12 hours after surge…

This study looks at how low oxygen levels during sleep (from obstructive sleep apnea) are connected to problems in the tiny blood vessels of the heart. Researchers will follow 560 adults with suspected heart issues to see if sleep apnea patterns can predict future heart events li…

This observational study will follow 1,500 adults with ventricular tachycardia (VT) to see how well different treatments work over the long term. Participants will receive either catheter ablation or non-ablation management (including drugs or an implantable defibrillator). The g…