Anrs, Emerging Infectious Diseases

This study compares a new nasal spray COVID-19 booster vaccine (LVT-001) to a standard mRNA booster shot in 238 healthy adults. The goal is to see if the nasal vaccine is safe and triggers a strong immune response, especially in the nose where the virus enters. It's an early-stag…

This study tests whether adding adalimumab (a drug used for arthritis) to standard treatment can reduce deaths in HIV patients with tuberculosis meningitis. About 130 adults in Brazil, Mozambique, and Zambia will receive either adalimumab or placebo alongside anti-TB drugs and st…

This study looks at whether giving a combination of two antiviral drugs or a longer treatment course can help people with weakened immune systems clear COVID-19 faster. About 256 participants with mild or no symptoms will receive either standard treatment or an enhanced approach.…

This study compares two different HIV medication combinations in people who have never taken HIV drugs before. One group gets doravirine plus tenofovir and lamivudine, the other gets dolutegravir plus tenofovir and either lamivudine or emtricitabine. The goal is to see if the dor…

This study follows 450 HIV-positive people who can keep the virus under control without taking antiretroviral drugs. Researchers want to understand how their immune systems do this and what happens over time. The goal is to learn more about the body's natural defenses against HIV…

This study follows up with 100 people who were part of the ANRS IPERGAY trial to see if certain HPV molecular signatures are linked to high-grade anal lesions or cancer 10 years later. Researchers will use high-resolution anoscopy to check for abnormalities. The goal is to better…