TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Clinical trials for TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER explained in plain language.
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Ketamine booster for shock therapy? new trial aims to lift depression and protect memory
Symptom relief Recruiting nowThis phase 3 trial tests whether adding a low dose of ketamine to electroconvulsive therapy (ECT) can better relieve depression and reduce memory problems in people with treatment-resistant major depressive disorder. Thirty hospitalized adults will receive either ketamine or a pl…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Università Vita-Salute San Raffaele • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Sound waves to lift mood? new study tests ultrasound for depression
Symptom relief Recruiting nowThis study tests a new, non-invasive brain stimulation method using low-intensity ultrasound waves aimed at specific brain areas linked to depression. Researchers will personalize the treatment for each of the 30 participants based on their brain scans. The goal is to see if this…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE1, PHASE2 • Sponsor: Brian Mickey • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Magic mushrooms take on depression: new trial tests psilocybin with antidepressants
Symptom relief Recruiting nowThis study tests whether a single dose of psilocybin mushrooms, combined with therapy, can help adults with treatment-resistant depression. Half of the 24 participants will also take the antidepressant fluoxetine to see if it changes the effects. The main goal is to measure mood …
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE1, PHASE2 • Sponsor: Federal University of Latin American Integration • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Can a VR seaside meditation lift depression that pills Can't?
Symptom relief Recruiting nowThis study tests whether adding virtual reality (VR) mindfulness sessions to standard treatment can help people with treatment-resistant depression feel better. Thirty adults who haven't responded to multiple antidepressants will either get usual care alone or usual care plus 8 V…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Hospital Universitari Vall d'Hebron Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Sound waves may unlock secrets of Treatment-Resistant depression
Knowledge-focused Recruiting nowThis study tests whether low-intensity focused ultrasound can temporarily change brain activity in people with treatment-resistant depression. Researchers will scan participants' brains before and after ultrasound to see how it affects mood-related circuits. The goal is not to tr…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Laureate Institute for Brain Research, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC