TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Clinical trials for TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER explained in plain language.
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Could a pill supercharge brain stimulation for depression?
Disease control Not yet recruitingThis study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2, PHASE3 • Sponsor: NeuroRx, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Could an arthritis drug lift the fog of Treatment-Resistant depression?
Symptom relief Not yet recruitingThis phase 2 trial tests whether a single infusion of tocilizumab, a drug that blocks the inflammatory molecule IL-6, can reduce depressive symptoms in 32 adults with treatment-resistant major depression. Participants must have high inflammation levels (CRP ≥3 mg/L) and will rece…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Hospital de Clinicas de Porto Alegre • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Can ketamine plus therapy curb suicidal thoughts? new trial aims to find out.
Symptom relief Not yet recruitingThis study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can reduce suicidal thoughts more effectively than a placebo plus DBT. About 120 adults with borderline personality disorder and treatment-resistant depression or bipolar disorder wil…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Joshua Rosenblat • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Psychedelic therapy gets personal: music or mindfulness for depression?
Symptom relief Not yet recruitingThis pilot study tests whether tailoring psilocybin-assisted therapy to a person's preferences (music or mindfulness) is practical and helpful for treatment-resistant depression. Sixteen adults will receive two doses of psilocybin, each paired with a different therapy style, to s…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Kyle Greenway • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Precision brain zapping: new hope for stubborn depression?
Symptom relief Not yet recruitingThis study tests a new method of delivering repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, the new method uses brain surface mapping to target a specific area. The trial will compare the two me…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Soterix Medical • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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New hope for Hard-to-Treat depression in seniors: esketamine spray vs aripiprazole
Symptom relief Not yet recruitingThis study compares two add-on treatments—esketamine nasal spray and aripiprazole pills—for older adults (60-74) whose depression hasn't improved with standard antidepressants. Around 220 participants will receive either esketamine once or twice weekly or daily aripiprazole, alon…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla • Aim: Symptom relief
Last updated Jun 26, 2026 13:33 UTC