TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Clinical trials for TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER explained in plain language.
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Could a pill supercharge brain stimulation for depression?
Disease control Not yet recruitingThis study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2, PHASE3 • Sponsor: NeuroRx, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Could an arthritis drug lift the fog of Treatment-Resistant depression?
Symptom relief Not yet recruitingThis phase 2 trial tests whether a single infusion of tocilizumab, a drug that blocks the inflammatory molecule IL-6, can reduce depressive symptoms in 32 adults with treatment-resistant major depression. Participants must have high inflammation levels (CRP ≥3 mg/L) and will rece…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Hospital de Clinicas de Porto Alegre • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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Psychedelic therapy gets personal: music or mindfulness for depression?
Symptom relief Not yet recruitingThis pilot study tests whether tailoring psilocybin-assisted therapy to a person's preferences (music or mindfulness) is practical and helpful for treatment-resistant depression. Sixteen adults will receive two doses of psilocybin, each paired with a different therapy style, to s…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Kyle Greenway • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Precision brain zapping: new hope for stubborn depression?
Symptom relief Not yet recruitingThis study tests a new method of delivering repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, the new method uses brain surface mapping to target a specific area. The trial will compare the two me…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Soterix Medical • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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New hope for Hard-to-Treat depression in seniors: esketamine spray vs aripiprazole
Symptom relief Not yet recruitingThis study compares two add-on treatments—esketamine nasal spray and aripiprazole pills—for older adults (60-74) whose depression hasn't improved with standard antidepressants. Around 220 participants will receive either esketamine once or twice weekly or daily aripiprazole, alon…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla • Aim: Symptom relief
Last updated Jun 26, 2026 13:33 UTC