TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Clinical trials for TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER explained in plain language.
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Which works best for stubborn depression? adding a drug, brain stimulation, or switching meds?
Disease control CompletedThis trial studies three approaches for adults with major depression that hasn't responded to standard antidepressants. Participants either add aripiprazole (Abilify) to their current medication, add repetitive transcranial magnetic stimulation (rTMS), or switch to venlafaxine XR…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Fast brain stimulation shows promise for stubborn depression
Symptom relief CompletedThis study tested an accelerated form of transcranial magnetic stimulation (TMS) in 50 adults with treatment-resistant depression. Participants received 50 sessions over two weeks, comparing a bilateral approach (stimulating both sides of the brain) with a unilateral one (stimula…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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Anesthetic drug shows promise for tough depression in early trial
Symptom relief CompletedThis early study tested whether a carefully controlled dose of propofol, a common anesthetic, could safely boost brain slow waves in 16 older adults with treatment-resistant depression. Participants received two propofol infusions days apart while researchers monitored brain acti…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Brain-Zap tech gets a GPS: virtual navigation aims to boost TMS for tough depression
Symptom relief CompletedThis study tested a virtual navigation system to help guide Transcranial Magnetic Stimulation (TMS) for people with treatment-resistant depression. The system aims to personalize the brain target for each patient. Twenty-two adults with major depressive disorder who had not respo…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Soterix Medical • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC