TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Clinical trials for TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER explained in plain language.
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Can a gentler brain stimulation replace ECT for tough depression?
Disease control TerminatedThis study looked at whether people with treatment-resistant depression who got better with electroconvulsive therapy (ECT) could switch to a less intense treatment called transcranial magnetic stimulation (TMS) to stay well. TMS is done in a clinic without anesthesia and has few…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Austin Messner • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Can a stronger jolt to the brain beat treatment-resistant depression?
Symptom relief TerminatedThis small pilot study tested a noninvasive brain stimulation technique called tDCS in 5 adults with major depression that hadn't improved after at least 3 antidepressant trials. Participants received up to 20 sessions of higher-than-usual electrical current over 4 to 6 weeks. Th…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Depression drug trial halted early: what we know
Symptom relief TerminatedThis study tested the drug tianeptine in 38 adults with major depression that did not improve after at least two other treatments. Participants took tianeptine three times a day for 8 weeks. The goal was to see if it reduced depression symptoms and changed how the brain processes…
Matched conditions: TREATMENT-RESISTANT MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: Jonathan A. Javitch, MD, PhD • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC